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Myo19 myosin XIX [ Mus musculus (house mouse) ]

Gene ID: 66196, updated on 14-Nov-2024

Summary

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Official Symbol
Myo19provided by MGI
Official Full Name
myosin XIXprovided by MGI
Primary source
MGI:MGI:1913446
See related
Ensembl:ENSMUSG00000020527 AllianceGenome:MGI:1913446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myohd1; 1110055A02Rik
Summary
Enables ATP hydrolysis activity; myosin light chain binding activity; and plus-end directed microfilament motor activity. Acts upstream of or within mitocytosis. Predicted to be located in cytosol and mitochondrial outer membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Is expressed in several structures, including adenohypophysis; alimentary system; skeleton; submandibular gland primordium; and vomeronasal organ. Orthologous to human MYO19 (myosin XIX). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 17.9), kidney adult (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Myo19 in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84770996..84802052)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84880170..84911226)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene gametogenetin binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene zinc finger, HIT type 3 Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor. Lu Z, et al. J Biol Chem, 2014 Jun 27. PMID 24825904, Free PMC Article
  2. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Jiao H, et al. Cell, 2021 May 27. PMID 34048705
  3. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Myo19 is a high-duty ratio molecular motor moving to the plus-end of the actin filament.
    Title: Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin light chain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables plus-end directed microfilament motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrion migration along actin filament ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unconventional myosin-XIX
Names
myosin head domain containing 1
myosin head domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362893.1 → NP_001349822.1  unconventional myosin-XIX isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK080117, AL645623
    Related
    ENSMUST00000124152.8
    Conserved Domains (2) summary
    pfam00612
    Location:511 → 531
    IQ; IQ calmodulin-binding motif
    cl22853
    Location:18 → 473
    Motor_domain; Myosin and Kinesin motor domain

  2. NM_025414.4 → NP_079690.2  unconventional myosin-XIX isoform 1

    See identical proteins and their annotated locations for NP_079690.2

    Status: VALIDATED

    Source sequence(s)
    AK018609, AK080117, AL645623, BC060115, BU613548, CA749671
    Consensus CDS
    CCDS48871.1
    UniProtKB/Swiss-Prot
    Q5SV80, Q8BH54, Q9D2Z3
    Related
    ENSMUSP00000091502.5, ENSMUST00000093969.11
    Conserved Domains (2) summary
    cd14880
    Location:49 → 746
    MYSc_Myo19; class XIX myosin, motor domain
    pfam00612
    Location:784 → 804
    IQ; IQ calmodulin-binding motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84770996..84802052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249173.3 → XP_011247475.1  unconventional myosin-XIX isoform X1

    See identical proteins and their annotated locations for XP_011247475.1

    UniProtKB/Swiss-Prot
    Q5SV80, Q8BH54, Q9D2Z3
    Conserved Domains (2) summary
    cd14880
    Location:49 → 746
    MYSc_Myo19; class XIX myosin, motor domain
    pfam00612
    Location:784 → 804
    IQ; IQ calmodulin-binding motif

  2. XM_036156894.1 → XP_036012787.1  unconventional myosin-XIX isoform X5

    Related
    ENSMUST00000141173.2
    Conserved Domains (2) summary
    pfam00612
    Location:511 → 531
    IQ; IQ calmodulin-binding motif
    cl22853
    Location:18 → 473
    Motor_domain; Myosin and Kinesin motor domain

  3. XM_011249174.3 → XP_011247476.1  unconventional myosin-XIX isoform X2

    Conserved Domains (2) summary
    cl22853
    Location:49 → 688
    Motor_domain; Myosin and Kinesin motor domain
    pfam00612
    Location:726 → 746
    IQ; IQ calmodulin-binding motif

  4. XM_030246221.1 → XP_030102081.1  unconventional myosin-XIX isoform X4

    Conserved Domains (2) summary
    pfam00612
    Location:575 → 595
    IQ; IQ calmodulin-binding motif
    cl22853
    Location:1 → 537
    Motor_domain; Myosin and Kinesin motor domain

  5. XM_036156892.1 → XP_036012785.1  unconventional myosin-XIX isoform X3

    Conserved Domains (2) summary
    pfam00612
    Location:639 → 659
    IQ; IQ calmodulin-binding motif
    cl22853
    Location:1 → 601
    Motor_domain; Myosin and Kinesin motor domain

  6. XM_036156893.1 → XP_036012786.1  unconventional myosin-XIX isoform X4

    Conserved Domains (2) summary
    pfam00612
    Location:575 → 595
    IQ; IQ calmodulin-binding motif
    cl22853
    Location:1 → 537
    Motor_domain; Myosin and Kinesin motor domain

  7. XM_036156895.1 → XP_036012788.1  unconventional myosin-XIX isoform X5

    Conserved Domains (2) summary
    pfam00612
    Location:511 → 531
    IQ; IQ calmodulin-binding motif
    cl22853
    Location:18 → 473
    Motor_domain; Myosin and Kinesin motor domain

  8. XM_006533930.4 → XP_006533993.1  unconventional myosin-XIX isoform X6

    Conserved Domains (2) summary
    cl22853
    Location:1 → 403
    Motor_domain; Myosin and Kinesin motor domain
    pfam00612
    Location:441 → 461
    IQ; IQ calmodulin-binding motif

RNA

  1. XR_003949489.1 RNA Sequence

  2. XR_004937003.1 RNA Sequence

  3. XR_879727.4 RNA Sequence

  4. XR_004937004.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SV80.1 GenPept UniProtKB/Swiss-Prot:Q5SV80

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