U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pycr3 pyrroline-5-carboxylate reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 66194, updated on 17-Aug-2024

Summary

Official Symbol
Pycr3provided by MGI
Official Full Name
pyrroline-5-carboxylate reductase 3provided by MGI
Primary source
MGI:MGI:1913444
See related
Ensembl:ENSMUSG00000022571 AllianceGenome:MGI:1913444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pycrl; 1110058B13Rik; 2700073G24Rik
Summary
Enables identical protein binding activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within cytidine deamination. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 50.1), duodenum adult (RPKM 48.8) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
15 D3; 15 35.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75788319..75793369, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75916463..75921560, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5 Neighboring gene GDP-L-fucose synthase Neighboring gene zinc finger protein 623

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytidine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyrroline-5-carboxylate reductase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-proline biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cytidine deamination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proline biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyrroline-5-carboxylate reductase 3
Names
P5C reductase 3
P5CR 3
pyrroline-5-carboxylate reductase-like protein
NP_079688.2
XP_006521315.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025412.3NP_079688.2  pyrroline-5-carboxylate reductase 3

    See identical proteins and their annotated locations for NP_079688.2

    Status: VALIDATED

    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS37109.1
    UniProtKB/Swiss-Prot
    Q8R0P9, Q9D0X2, Q9DCC4
    Related
    ENSMUSP00000049605.8, ENSMUST00000053918.9
    Conserved Domains (3) summary
    PLN02688
    Location:10273
    PLN02688; pyrroline-5-carboxylate reductase
    pfam03807
    Location:12104
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
    pfam14748
    Location:166270
    P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75788319..75793369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521252.4XP_006521315.1  pyrroline-5-carboxylate reductase 3 isoform X1

    Conserved Domains (1) summary
    TIGR00112
    Location:1161
    proC; pyrroline-5-carboxylate reductase