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Ubl5 ubiquitin-like 5 [ Mus musculus (house mouse) ]

Gene ID: 66177, updated on 2-Nov-2024

Summary

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Official Symbol
Ubl5provided by MGI
Official Full Name
ubiquitin-like 5provided by MGI
Primary source
MGI:MGI:1913427
See related
Ensembl:ENSMUSG00000084786 AllianceGenome:MGI:1913427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubl5a; beacon; 1110030M22Rik
Summary
Predicted to enable protein tag activity. Predicted to be involved in mRNA splicing, via spliceosome and protein modification process. Predicted to be active in cytoplasm and nucleus. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Orthologous to human UBL5 (ubiquitin like 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 32.6), thymus adult (RPKM 28.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ubl5 in Genome Data Viewer
Location:
9 A3; 9 7.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20554013..20558436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20642717..20647140)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene zinc finger protein 846 Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene olfactomedin 2 Neighboring gene predicted gene, 39299

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death. Wang W, et al. J Biol Chem, 2023 Jul. PMID 37315790, Free PMC Article
  2. Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5. Hatanaka K, et al. Biochem Biophys Res Commun, 2006 Nov 24. PMID 17026961
  3. Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse. Brailoiu GC, et al. Brain Res, 2003 Sep 12. PMID 12932856
  4. Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes†. Tscherner AK, et al. Biol Reprod, 2023 Nov 15. PMID 37669129, Free PMC Article
  5. Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Zou J, et al. Proc Natl Acad Sci U S A, 2018 Apr 24. PMID 29632206, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death.
    Title: Ubiquitin-like protein 5 is a novel player in the UPR-PERK arm and ER stress-induced cell death.
  2. This report is the first to describe changes in the intracellular and subcellular localization of UBL5 in response to hypo-osmotic conditions.
    Title: Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5.
  3. findings report of the presence and distribution of ubiquitin-like 5 in the mouse hypothalamus and pituitary
    Title: Beacon/ubiquitin-like 5-immunoreactivity in the hypothalamus and pituitary of the mouse.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-like protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310746.2 → NP_001297675.1  ubiquitin-like protein 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC164565
    Consensus CDS
    CCDS80963.1
    UniProtKB/TrEMBL
    E0CZB3
    Related
    ENSMUSP00000125540.2, ENSMUST00000161882.8
    Conserved Domains (1) summary
    cd01791
    Location:1 → 111
    Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

  2. NM_001361025.1 → NP_001347954.1  ubiquitin-like protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164565
    Consensus CDS
    CCDS52733.1
    UniProtKB/Swiss-Prot
    Q9EPV8
    Related
    ENSMUSP00000124672.2, ENSMUST00000160682.8
    Conserved Domains (1) summary
    cd01791
    Location:1 → 71
    Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

  3. NM_001361026.1 → NP_001347955.1  ubiquitin-like protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK009854, CD350466
    Consensus CDS
    CCDS90506.1
    UniProtKB/TrEMBL
    E0CY38
    Related
    ENSMUSP00000124506.2, ENSMUST00000161486.8
    Conserved Domains (1) summary
    cl00155
    Location:1 → 50
    UBQ; Ubiquitin-like proteins

  4. NM_001361027.1 → NP_001347956.1  ubiquitin-like protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164565, AK009854, BF472858, BU705105
    Consensus CDS
    CCDS52733.1
    UniProtKB/Swiss-Prot
    Q9EPV8
    Related
    ENSMUSP00000124812.2, ENSMUST00000162303.8
    Conserved Domains (1) summary
    cd01791
    Location:1 → 71
    Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

  5. NM_025401.4 → NP_079677.1  ubiquitin-like protein 5 isoform 2

    See identical proteins and their annotated locations for NP_079677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK051149, BU705105
    Consensus CDS
    CCDS52733.1
    UniProtKB/Swiss-Prot
    Q9EPV8
    Related
    ENSMUSP00000123971.2, ENSMUST00000129414.9
    Conserved Domains (1) summary
    cd01791
    Location:1 → 71
    Ubl_UBL5; ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins

RNA

  1. NR_153857.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164565
    Related
    ENSMUST00000154429.9

  2. NR_153858.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164565, AK009854, BU705105, CJ041902
    Related
    ENSMUST00000160874.8

  3. NR_153859.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164565

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20554013..20558436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPV8.1 GenPept UniProtKB/Swiss-Prot:Q9EPV8

Gene LinkOut

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