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Polr1h RNA polymerase I subunit H [ Mus musculus (house mouse) ]

Gene ID: 66136, updated on 2-Nov-2024

Summary

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Official Symbol
Polr1hprovided by MGI
Official Full Name
RNA polymerase I subunit Hprovided by MGI
Primary source
MGI:MGI:1913386
See related
Ensembl:ENSMUSG00000036315 AllianceGenome:MGI:1913386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpa12; Znrd1; 1110014N07Rik
Summary
Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex. Is expressed in early conceptus; genitourinary system; and limb. Orthologous to human POLR1H (RNA polymerase I subunit H). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.1), CNS E11.5 (RPKM 17.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Polr1h in Genome Data Viewer
Location:
17 B1; 17 19.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37265250..37269417, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36954358..36958525, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 39 Neighboring gene predicted gene, 33595 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 11 Neighboring gene STARR-positive B cell enhancer ABC_E7532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37088519-37088789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37095409-37095518 Neighboring gene RNA polymerase I subunit H, antisense Neighboring gene histocompatibility 2, M region locus 6, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of RNA polymerase I transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase I subunit RPA12
Names
DNA-directed RNA polymerase I subunit H
nuclear RNA polymerase I small specific subunit
zinc ribbon domain containing 1
zinc ribbon domain-containing protein 1
NP_001342351.1
NP_075651.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355422.1 → NP_001342351.1  DNA-directed RNA polymerase I subunit RPA12

    Status: VALIDATED

    Source sequence(s)
    CR956641
    Consensus CDS
    CCDS28730.1
    UniProtKB/Swiss-Prot
    Q791N7
    UniProtKB/TrEMBL
    G3UXD3
    Related
    ENSMUSP00000133651.2, ENSMUST00000172518.8
    Conserved Domains (2) summary
    cd10507
    Location:76 → 122
    Zn-ribbon_RPA12; C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I
    cl27574
    Location:17 → 46
    OrfB_Zn_ribbon; Putative transposase DNA-binding domain

  2. NM_023162.4 → NP_075651.1  DNA-directed RNA polymerase I subunit RPA12

    See identical proteins and their annotated locations for NP_075651.1

    Status: VALIDATED

    Source sequence(s)
    AK003714
    Consensus CDS
    CCDS28730.1
    UniProtKB/Swiss-Prot
    Q791N7
    UniProtKB/TrEMBL
    G3UXD3
    Related
    ENSMUSP00000109299.3, ENSMUST00000113669.9
    Conserved Domains (2) summary
    cd10507
    Location:76 → 122
    Zn-ribbon_RPA12; C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I
    cl27574
    Location:17 → 46
    OrfB_Zn_ribbon; Putative transposase DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37265250..37269417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q791N7.1 GenPept UniProtKB/Swiss-Prot:Q791N7

Gene LinkOut

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