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Tsen34 tRNA splicing endonuclease subunit 34 [ Mus musculus (house mouse) ]

Gene ID: 66078, updated on 2-Nov-2024

Summary

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Official Symbol
Tsen34provided by MGI
Official Full Name
tRNA splicing endonuclease subunit 34provided by MGI
Primary source
MGI:MGI:1913328
See related
Ensembl:ENSMUSG00000035585 AllianceGenome:MGI:1913328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Leng5; 0610027F08Rik
Summary
Predicted to enable tRNA-intron endonuclease activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 57.5), ovary adult (RPKM 44.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tsen34 in Genome Data Viewer
Location:
7 A1; 7 2.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3696300..3704033)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3693087..3701035)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene transmembrane channel-like gene family 4 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2812 Neighboring gene ribosomal protein S9 Neighboring gene paired Ig-like receptor B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J. Timmermans S, et al. JCI Insight, 2018 Jul 12. PMID 29997285, Free PMC Article
  2. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-intron endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-intron endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA-type intron splice site recognition and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA-type intron splice site recognition and cleavage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of tRNA-intron endonuclease complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA-splicing endonuclease subunit Sen34
Names
leukocyte receptor cluster (LRC) member 5
leukocyte receptor cluster member 5 homolog
tRNA splicing endonuclease 34 homolog
tRNA-intron endonuclease Sen34
NP_001157676.1
NP_001157677.1
NP_001406977.1
NP_001406980.1
NP_001406981.1
NP_001406982.1
NP_001406983.1
NP_001406984.1
NP_001406985.1
NP_001406986.1
NP_001406987.1
NP_001406989.1
NP_001406990.1
NP_001406991.1
NP_077130.1
XP_006540343.2
XP_017167711.2
XP_017167713.1
XP_017167714.1
XP_017167715.1
XP_036009227.1
XP_036009228.1
XP_036009230.1
XP_036009231.1
XP_036009232.1
XP_036009233.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164204.2 → NP_001157676.1  tRNA-splicing endonuclease subunit Sen34 isoform a

    See identical proteins and their annotated locations for NP_001157676.1

    Status: VALIDATED

    Source sequence(s)
    AC171680
    Consensus CDS
    CCDS20725.1
    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
    Related
    ENSMUSP00000104270.2, ENSMUST00000108630.8
    Conserved Domains (2) summary
    pfam03985
    Location:98 → 170
    Paf1
    pfam01974
    Location:223 → 307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  2. NM_001164205.2 → NP_001157677.1  tRNA-splicing endonuclease subunit Sen34 isoform b

    See identical proteins and their annotated locations for NP_001157677.1

    Status: VALIDATED

    Source sequence(s)
    AC171680
    Consensus CDS
    CCDS51966.1
    UniProtKB/Swiss-Prot
    Q8BMZ5
    UniProtKB/TrEMBL
    Q9CWG3
    Related
    ENSMUSP00000104269.2, ENSMUST00000108629.8
    Conserved Domains (1) summary
    pfam01974
    Location:223 → 278
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  3. NM_001420048.1 → NP_001406977.1  tRNA-splicing endonuclease subunit Sen34 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171680

  4. NM_001420051.1 → NP_001406980.1  tRNA-splicing endonuclease subunit Sen34 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171680

  5. NM_001420052.1 → NP_001406981.1  tRNA-splicing endonuclease subunit Sen34 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171680

  6. NM_001420053.1 → NP_001406982.1  tRNA-splicing endonuclease subunit Sen34 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC171680
    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1

  7. NM_001420054.1 → NP_001406983.1  tRNA-splicing endonuclease subunit Sen34 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC171680
    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1

  8. NM_001420055.1 → NP_001406984.1  tRNA-splicing endonuclease subunit Sen34 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC171680
    UniProtKB/TrEMBL
    H7BX14
    Related
    ENSMUSP00000046911.8, ENSMUST00000038521.14

  9. NM_001420056.1 → NP_001406985.1  tRNA-splicing endonuclease subunit Sen34 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC171680

  10. NM_001420057.1 → NP_001406986.1  tRNA-splicing endonuclease subunit Sen34 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC171680

  11. NM_001420058.1 → NP_001406987.1  tRNA-splicing endonuclease subunit Sen34 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC171680
    UniProtKB/TrEMBL
    A0A0U1RPF7

  12. NM_001420060.1 → NP_001406989.1  tRNA-splicing endonuclease subunit Sen34 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC171680
    UniProtKB/TrEMBL
    A0A0U1RPF7
    Related
    ENSMUSP00000145965.2, ENSMUST00000205287.2

  13. NM_001420061.1 → NP_001406990.1  tRNA-splicing endonuclease subunit Sen34 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC171680

  14. NM_001420062.1 → NP_001406991.1  tRNA-splicing endonuclease subunit Sen34 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC171680

  15. NM_024168.3 → NP_077130.1  tRNA-splicing endonuclease subunit Sen34 isoform a

    See identical proteins and their annotated locations for NP_077130.1

    Status: VALIDATED

    Source sequence(s)
    AC171680
    Consensus CDS
    CCDS20725.1
    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
    Related
    ENSMUSP00000104267.4, ENSMUST00000108627.4
    Conserved Domains (2) summary
    pfam03985
    Location:98 → 170
    Paf1
    pfam01974
    Location:223 → 307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

RNA

  1. NR_185127.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171680

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3696300..3704033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312222.3 → XP_017167711.2  tRNA-splicing endonuclease subunit Sen34 isoform X4

    Conserved Domains (1) summary
    pfam01974
    Location:264 → 348
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  2. XM_017312224.3 → XP_017167713.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98 → 170
    Paf1
    pfam01974
    Location:223 → 307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  3. XM_036153335.1 → XP_036009228.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224 → 256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  4. XM_036153338.1 → XP_036009231.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224 → 256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  5. XM_036153337.1 → XP_036009230.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224 → 256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  6. XM_006540280.5 → XP_006540343.2  tRNA-splicing endonuclease subunit Sen34 isoform X2

    Conserved Domains (1) summary
    pfam01974
    Location:247 → 331
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  7. XM_017312225.3 → XP_017167714.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98 → 170
    Paf1
    pfam01974
    Location:223 → 307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  8. XM_017312226.3 → XP_017167715.1  tRNA-splicing endonuclease subunit Sen34 isoform X5

    UniProtKB/Swiss-Prot
    Q58EU2, Q8BMZ5, Q99LV6, Q9CYW1
    Conserved Domains (2) summary
    pfam03985
    Location:98 → 170
    Paf1
    pfam01974
    Location:223 → 307
    tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain

  9. XM_036153334.1 → XP_036009227.1  tRNA-splicing endonuclease subunit Sen34 isoform X1

    Conserved Domains (1) summary
    cd22363
    Location:248 → 280
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  10. XM_036153340.1 → XP_036009233.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224 → 256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

  11. XM_036153339.1 → XP_036009232.1  tRNA-splicing endonuclease subunit Sen34 isoform X3

    Conserved Domains (1) summary
    cd22363
    Location:224 → 256
    tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

RNA

  1. XR_003946537.1 RNA Sequence

  2. XR_003946540.2 RNA Sequence

  3. XR_003946539.2 RNA Sequence

  4. XR_001777993.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMZ5.2 GenPept UniProtKB/Swiss-Prot:Q8BMZ5

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