Egfr Epidermal growth factor receptor [Tribolium castaneum (red flour beetle)] - Gene

Summary

Gene symbol: Egfr
Gene description: Epidermal growth factor receptor
Locus tag: TcasGA2_TC003985
Gene type: protein coding
RefSeq status: MODEL
Organism: Tribolium castaneum
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
Also known as: DER; top; Ellipse; torpedo
Orthologs: fruit fly all
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Genomic context

Location:: chromosome: 1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_04	current	icTriCast1.1 (GCF_031307605.1)	1	NC_087394.1 (3582161..3692176)
103	previous assembly	Tcas5.2 (GCF_000002335.3)	Linkage Group LG3	NC_007418.3 (29128385..29236246, complement)

Chromosome 1 - NC_087394.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of EGFR signaling by Tc-Vein and Tc-Spitz regulates the metamorphic transition in the red flour beetle Tribolium castaneum.
Title: Activation of EGFR signaling by Tc-Vein and Tc-Spitz regulates the metamorphic transition in the red flour beetle Tribolium castaneum.
Studied the role of Egfr, spi and pnt in leg development in the beetle Tribolium castaneum and show that Egfr signaling has a more complex role in T. castaneum than in D. melanogaster and is not only required in the distal leg, but is also involved in formation of the medial leg (including femur and tibia).
Title: Egfr signaling regulates distal as well as medial fate in the embryonic leg of Tribolium castaneum.

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General gene information

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Markers

32.D12s (e-PCR), detects polymorphism
- UniSTS:479546

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: epidermal growth factor receptor

Names: AUGUSTUS-3.0.2_03986; AUGUSTUS-3.0.2_32673; GLEAN_03985; GLEAN_03986

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference icTriCast1.1 Primary Assembly

Genomic

NC_087394.1 Reference icTriCast1.1 Primary Assembly

Range

3582161..3692176

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015978717.2 → XP_015834203.1 epidermal growth factor receptor isoform X1

UniProtKB/TrEMBL

D6WIE7

Conserved Domains (7) summary

smart00219
Location:894 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:743 → 793

FU; Furin-like repeats

cd00064
Location:257 → 297

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05057
Location:886 → 1162

PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases

pfam00757
Location:209 → 356

Furin-like; Furin-like cysteine rich region

pfam01030
Location:374 → 501

Recep_L_domain; Receptor L domain

pfam14843
Location:526 → 638

GF_recep_IV; Growth factor receptor domain IV
XM_008193272.3 → XP_008191494.1 epidermal growth factor receptor isoform X2

Conserved Domains (7) summary

smart00219
Location:865 → 1120

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:714 → 764

FU; Furin-like repeats

cd00064
Location:228 → 268

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05057
Location:857 → 1133

PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases

pfam00757
Location:180 → 327

Furin-like; Furin-like cysteine rich region

pfam01030
Location:345 → 472

Recep_L_domain; Receptor L domain

pfam14843
Location:497 → 609

GF_recep_IV; Growth factor receptor domain IV
XM_008193271.3 → XP_008191493.1 epidermal growth factor receptor isoform X1

UniProtKB/TrEMBL

D6WIE7

Conserved Domains (7) summary

smart00219
Location:894 → 1149

TyrKc; Tyrosine kinase, catalytic domain

smart00261
Location:743 → 793

FU; Furin-like repeats

cd00064
Location:257 → 297

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

cd05057
Location:886 → 1162

PTKc_EGFR_like; Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases

pfam00757
Location:209 → 356

Furin-like; Furin-like cysteine rich region

pfam01030
Location:374 → 501

Recep_L_domain; Receptor L domain

pfam14843
Location:526 → 638

GF_recep_IV; Growth factor receptor domain IV