U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DLK2 delta like non-canonical Notch ligand 2 [ Homo sapiens (human) ]

Gene ID: 65989, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
DLK2provided by HGNC
Official Full Name
delta like non-canonical Notch ligand 2provided by HGNC
Primary source
HGNC:HGNC:21113
See related
Ensembl:ENSG00000171462 AllianceGenome:HGNC:21113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLK-2; EGFL9
Summary
Predicted to enable Notch binding activity. Involved in negative regulation of Notch signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 1.9), prostate (RPKM 1.6) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6p21.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43450352..43456632, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43279119..43285399, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43418090..43424370, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375065 Neighboring gene Sharpr-MPRA regulatory region 12040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43380603-43381102 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:43393233-43393754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24600 Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene microRNA 6780b Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17231 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43423943-43424784 Neighboring gene MPRA-validated peak5814 silencer Neighboring gene RNA, U6 small nuclear 1113, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43445658-43446451 Neighboring gene tight junction associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43457381-43457974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43457975-43458569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17232

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming. Meng F, et al. Nat Commun, 2019 Nov 6. PMID 31695034, Free PMC Article
  2. Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo. Naranjo AI, et al. Int J Mol Sci, 2022 Jan 29. PMID 35163478, Free PMC Article
  3. The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis. Nueda ML, et al. J Mol Biol, 2007 Apr 13. PMID 17320102
  4. The proteins DLK1 and DLK2 modulate NOTCH1-dependent proliferation and oncogenic potential of human SK-MEL-2 melanoma cells. Nueda ML, et al. Biochim Biophys Acta, 2014 Nov. PMID 25093684
  5. The DNA sequence and analysis of human chromosome 6. Mungall AJ, et al. Nature, 2003 Oct 23. PMID 14574404

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.
    Title: Different Expression Levels of DLK2 Inhibit NOTCH Signaling and Inversely Modulate MDA-MB-231 Breast Cancer Tumor Growth In Vivo.
  2. EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
    Title: EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
  3. Studies in mouse showed that dlk2, highly homologous to dlk1 (also known as pref-1, and FA-1) appears to modulate adipogenesis in vitro in an opposite way to that of dlk1.
    Title: The novel gene EGFL9/Dlk2, highly homologous to Dlk1, functions as a modulator of adipogenesis.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC2487, MGC111055

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein delta homolog 2
Names
EGF-like protein 9
EGF-like-domain, multiple 9
delta-like 2 homolog
epidermal growth factor-like protein 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286655.1 → NP_001273584.1  protein delta homolog 2 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the central coding region, compared to variant 2. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AK055380, BC110320, DA332624
    UniProtKB/TrEMBL
    H0Y5P1
    Conserved Domains (1) summary
    cd00054
    Location:137 → 173
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. NM_001286656.2 → NP_001273585.1  protein delta homolog 2 isoform c precursor

    See identical proteins and their annotated locations for NP_001273585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the central coding region, compared to variant 2. The encoded isoform (c) is shorter, compared to isoform a.
    Source sequence(s)
    BC110320, BM811564
    Consensus CDS
    CCDS75461.1
    UniProtKB/TrEMBL
    Q5T3T9
    Related
    ENSP00000361563.1, ENST00000372485.5
    Conserved Domains (1) summary
    cd00054
    Location:168 → 204
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  3. NM_023932.4 → NP_076421.2  protein delta homolog 2 isoform a precursor

    See identical proteins and their annotated locations for NP_076421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC110320
    Consensus CDS
    CCDS4897.1
    UniProtKB/Swiss-Prot
    B3KNZ7, Q5T3T8, Q6UY11, Q9BQ54
    Related
    ENSP00000361566.3, ENST00000372488.8
    Conserved Domains (1) summary
    cd00054
    Location:174 → 210
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  4. NM_206539.2 → NP_996262.1  protein delta homolog 2 isoform a precursor

    See identical proteins and their annotated locations for NP_996262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK055380, AY358126
    Consensus CDS
    CCDS4897.1
    UniProtKB/Swiss-Prot
    B3KNZ7, Q5T3T8, Q6UY11, Q9BQ54
    Related
    ENSP00000349893.3, ENST00000357338.3
    Conserved Domains (1) summary
    cd00054
    Location:174 → 210
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43450352..43456632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419264.1 → XP_047275220.1  protein delta homolog 2 isoform X3

  2. XM_047419263.1 → XP_047275219.1  protein delta homolog 2 isoform X3

  3. XM_005249308.6 → XP_005249365.1  protein delta homolog 2 isoform X1

    Conserved Domains (1) summary
    cd00054
    Location:267 → 303
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  4. XM_011514823.4 → XP_011513125.1  protein delta homolog 2 isoform X2

    Conserved Domains (1) summary
    cd00054
    Location:236 → 272
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  5. XM_047419265.1 → XP_047275221.1  protein delta homolog 2 isoform X4

    Related
    ENSP00000399829.1, ENST00000430324.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43279119..43285399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356261.1 → XP_054212236.1  protein delta homolog 2 isoform X3

  2. XM_054356258.1 → XP_054212233.1  protein delta homolog 2 isoform X1

  3. XM_054356260.1 → XP_054212235.1  protein delta homolog 2 isoform X3

  4. XM_054356259.1 → XP_054212234.1  protein delta homolog 2 isoform X2

  5. XM_054356262.1 → XP_054212237.1  protein delta homolog 2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UY11.1 GenPept UniProtKB/Swiss-Prot:Q6UY11

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous