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SLC16A1 solute carrier family 16 member 1 [ Homo sapiens (human) ]

Gene ID: 6566, updated on 7-Apr-2024

Summary

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Official Symbol
SLC16A1provided by HGNC
Official Full Name
solute carrier family 16 member 1provided by HGNC
Primary source
HGNC:HGNC:10922
See related
Ensembl:ENSG00000155380 MIM:600682; AllianceGenome:HGNC:10922
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT; HHF7; MCT1; MCT1D
Summary
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]
Expression
Broad expression in heart (RPKM 23.3), colon (RPKM 22.1) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
1p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112911847..112956196, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112924405..112968780, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113454469..113498818, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 11399 Neighboring gene uncharacterized LOC124904342 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:113440206-113440749 Neighboring gene ribosomal protein L39 pseudogene 8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113444917-113445850 Neighboring gene Sharpr-MPRA regulatory region 4510 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113448786-113449345 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113453686-113454297 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113454298-113454908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113465491-113466356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113466357-113467221 Neighboring gene AKR7A2 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113486444-113486944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113497825-113498414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:113499595-113500183 Neighboring gene SLC16A1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113511652-113512152 Neighboring gene uncharacterized LOC107985189

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review. Silva A, et al. Int J Mol Sci, 2023 Mar 7. PMID 36982217, Free PMC Article
  2. Comprehensive analysis of pan-cancer reveals the potential of SLC16A1 as a prognostic and immunological biomarker. Chen L, et al. Medicine (Baltimore), 2023 Mar 17. PMID 36930112, Free PMC Article
  3. Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes. Dzitkowska-Zabielska M, et al. Genes (Basel), 2022 May 12. PMID 35627255, Free PMC Article
  4. A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer. Hao Q, et al. Adv Sci (Weinh), 2022 Feb. PMID 35023320, Free PMC Article
  5. Influence of the MCT1-T1470A polymorphism (rs1049434) on repeated sprint ability and blood lactate accumulation in elite football players: a pilot study. Massidda M, et al. Eur J Appl Physiol, 2021 Dec. PMID 34480633

See all (293) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.
    Title: Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.
  2. To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1.DENR to deliver initiator tRNA to ribosomes.
    Title: To initiate or not to initiate: A critical assessment of eIF2A, eIF2D, and MCT-1·DENR to deliver initiator tRNA to ribosomes.
  3. MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation.
    Title: MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation.
  4. Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells.
    Title: Role of monocarboxylate transporter I/lactate dehydrogenase B-mediated lactate recycling in tamoxifen-resistant breast cancer cells.
  5. SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle.
    Title: SETDB1 Methylates MCT1 Promoting Tumor Progression by Enhancing the Lactate Shuttle.
  6. Comprehensive analysis of pan-cancer reveals the potential of SLC16A1 as a prognostic and immunological biomarker.
    Title: Comprehensive analysis of pan-cancer reveals the potential of SLC16A1 as a prognostic and immunological biomarker.
  7. Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
    Title: Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
  8. Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
    Title: Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
  9. Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
    Title: Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
  10. Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line.
    Title: Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line.
Submit: New GeneRIF Correction See all GeneRIFs (166)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36745, MGC44475

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables lactate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lactate transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables lactate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lactate:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mevalonate transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables organic cyclic compound binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in behavioral response to nutrient IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mevalonate transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in monocarboxylic acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monocarboxylic acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane lactate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane lactate transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane lactate transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to food IEA
Inferred from Electronic Annotation
more info
  
involved_in succinate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transport across blood-brain barrier NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 1
Names
MCT 1
solute carrier family 16 (monocarboxylate transporter), member 1
solute carrier family 16 (monocarboxylic acid transporters), member 1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015880.2 RefSeqGene

    Range
    4733..49082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001166496.2 → NP_001159968.1  monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_001159968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI656300, AK094064, AK296688, AL158844, AL162079, BC026317, BP294493
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985, Q49A45, Q5T8R6, Q9NSJ9
    UniProtKB/TrEMBL
    B2R6A5
    Related
    ENSP00000441065.1, ENST00000538576.5
    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 455
    2A0113; monocarboxylate transporter 1

  2. NM_003051.4 → NP_003042.3  monocarboxylate transporter 1

    See identical proteins and their annotated locations for NP_003042.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL158844
    Consensus CDS
    CCDS858.1
    UniProtKB/Swiss-Prot
    P53985, Q49A45, Q5T8R6, Q9NSJ9
    UniProtKB/TrEMBL
    B2R6A5
    Related
    ENSP00000358640.4, ENST00000369626.8
    Conserved Domains (1) summary
    TIGR00892
    Location:1 → 455
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    112911847..112956196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428789.1 → XP_047284745.1  monocarboxylate transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P53985, Q49A45, Q5T8R6, Q9NSJ9
    Related
    ENSP00000399104.2, ENST00000443580.6

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_009646196.1 Reference GRCh38.p14 PATCHES

    Range
    2426..46775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331540.1 → XP_054187515.1  monocarboxylate transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P53985, Q49A45, Q5T8R6, Q9NSJ9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    112924405..112968780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338454.1 → XP_054194429.1  monocarboxylate transporter 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53985.3 GenPept UniProtKB/Swiss-Prot:P53985

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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