U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

IQCJ IQ motif containing J [ Homo sapiens (human) ]

Gene ID: 654502, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
IQCJprovided by HGNC
Official Full Name
IQ motif containing Jprovided by HGNC
Primary source
HGNC:HGNC:32406
See related
Ensembl:ENSG00000214216 MIM:611622; AllianceGenome:HGNC:32406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See IQCJ in Genome Data Viewer
Location:
3q25.32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (159069319..159266307)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (161843121..162040655)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158787108..158984096)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374181 Neighboring gene MPRA-validated peak4882 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14849 Neighboring gene uncharacterized LOC124909452 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:158654234-158655433 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158708772-158709358 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158770193-158770383 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:158780440-158780973 Neighboring gene IQCJ-SCHIP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20753 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:158946859-158947462 Neighboring gene MPRA-validated peak4886 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr3:159058830-159059398 Neighboring gene microRNA 3919 Neighboring gene schwannomin interacting protein 1 Neighboring gene ribosomal protein S2 pseudogene 19

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans. Vallée Marcotte B, et al. Int J Mol Sci, 2017 Jan 26. PMID 28134766, Free PMC Article
  2. Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation. Vallée Marcotte B, et al. J Nutrigenet Nutrigenomics, 2016. PMID 27160456
  3. IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein. Kwaśnicka-Crawford DA, et al. Biochem Biophys Res Commun, 2006 Dec 1. PMID 17045569
  4. Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments. Martin PM, et al. J Neurosci, 2008 Jun 11. PMID 18550753, Free PMC Article
  5. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Hou P, et al. Cancer Res, 2017 Aug 15. PMID 28625976, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Readthrough IQCJ-SCHIP1

Readthrough gene: IQCJ-SCHIP1, Included gene: SCHIP1

Homology

General protein information

Go to the top of the page Help
Preferred Names
IQ domain-containing protein J
Names
calmodulin binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042705.3 → NP_001036170.1  IQ domain-containing protein J isoform CaMBPv1

    See identical proteins and their annotated locations for NP_001036170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (CaMBPv1).
    Source sequence(s)
    AK309049, DA305468, DQ309553
    Consensus CDS
    CCDS46946.1
    UniProtKB/Swiss-Prot
    B7ZMM2, B9EH97, Q1A5X5, Q1A5X6
    Related
    ENSP00000402153.1, ENST00000451172.5
    Conserved Domains (1) summary
    pfam15157
    Location:4 → 155
    IQCJ-SCHIP1; Fusion protein IQCJ-SCHIP1 with IQ-like motif

  2. NM_001042706.3 → NP_001036171.1  IQ domain-containing protein J isoform CaMBPv2

    See identical proteins and their annotated locations for NP_001036171.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon and thereby differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (CaMBPv2) has a distinct and shorter C-terminus, compared to isoform CaMBPv1.
    Source sequence(s)
    DA305468, DQ309554
    Consensus CDS
    CCDS46947.1
    UniProtKB/Swiss-Prot
    Q1A5X6
    Related
    ENSP00000380932.2, ENST00000397832.7
    Conserved Domains (1) summary
    pfam15157
    Location:4 → 112
    IQCJ-SCHIP1; Fusion protein IQCJ-SCHIP1 with IQ-like motif

  3. NM_001197100.2 → NP_001184029.1  IQ domain-containing protein J isoform CaMBPv3

    See identical proteins and their annotated locations for NP_001184029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (CaMBPv3) that is shorter than isoform CaMBPv1.
    Source sequence(s)
    AK309049, DA305468
    Consensus CDS
    CCDS56290.1
    UniProtKB/Swiss-Prot
    Q1A5X6
    Related
    ENSP00000418141.1, ENST00000482126.1
    Conserved Domains (1) summary
    pfam15157
    Location:4 → 128
    IQCJ-SCHIP1; Fusion protein IQCJ-SCHIP1 with IQ-like motif

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    159069319..159266307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    161843121..162040655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1A5X6.1 GenPept UniProtKB/Swiss-Prot:Q1A5X6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous