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Kncn kinocilin [ Mus musculus (house mouse) ]

Gene ID: 654462, updated on 2-Nov-2024

Summary

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Official Symbol
Kncnprovided by MGI
Official Full Name
kinocilinprovided by MGI
Primary source
MGI:MGI:3614952
See related
Ensembl:ENSMUSG00000073774 AllianceGenome:MGI:3614952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L5; Kino
Summary
Located in several cellular components, including apical plasma membrane; cytoskeleton; and kinocilium. Is expressed in several structures, including eye; inner ear; liver; lung; and testis. Orthologous to human KNCN (kinocilin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Kncn in Genome Data Viewer
Location:
4 D1; 4 53.06 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115741597..115745079)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115884400..115887882)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 3C Neighboring gene STARR-seq mESC enhancer starr_11125 Neighboring gene STARR-positive B cell enhancer ABC_E1650 Neighboring gene MAP kinase-interacting serine/threonine kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6199 Neighboring gene transmembrane protein 275 Neighboring gene diencephalon/mesencephalon homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells. Hu Q, et al. Front Mol Neurosci, 2018. PMID 30254566, Free PMC Article
  2. Initial characterization of kinocilin, a protein of the hair cell kinocilium. Leibovici M, et al. Hear Res, 2005 May. PMID 15855039
  3. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Kitajiri S, et al. Cell, 2010 May 28. PMID 20510926, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cuticular plate IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cuticular plate IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in kinocilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinocilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinocilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039124.4 → NP_001034213.1  kinocilin isoform 2

    See identical proteins and their annotated locations for NP_001034213.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL627085, BC132036
    Consensus CDS
    CCDS18499.1
    UniProtKB/Swiss-Prot
    Q307W7
    Related
    ENSMUSP00000095531.3, ENSMUST00000097918.3
    Conserved Domains (1) summary
    pfam15033
    Location:1 → 116
    Kinocilin; Kinocilin protein

  2. NM_001320545.1 → NP_001307474.1  kinocilin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL627085, BC145375
    UniProtKB/TrEMBL
    B7ZNQ4
    Conserved Domains (1) summary
    pfam15033
    Location:1 → 126
    Kinocilin; Kinocilin protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115741597..115745079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q307W7.1 GenPept UniProtKB/Swiss-Prot:Q307W7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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