ZG16 zymogen granule protein 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZG16provided by HGNC
Official Full Name: zymogen granule protein 16provided by HGNC
Primary source: HGNC:HGNC:30961
See related: Ensembl:ENSG00000174992 MIM:617311; AllianceGenome:HGNC:30961
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JCLN; JCLN1; ZG16A
Summary: Predicted to enable carbohydrate binding activity and peptidoglycan binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in Golgi lumen and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon (RPKM 333.1), small intestine (RPKM 82.8) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 16p11.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (29778256..29782973)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (30060382..30065096)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (29789577..29794294)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
Title: Conformational switches and redox properties of the colon cancer-associated human lectin ZG16.
our study demonstrated that ZG16 expression was sequentially reduced from normal, adenoma, to carcinoma. Association with multiple clinicopathological features indicates that ZG16 may play an important role in cancer initiation and progression. ZG16 may serve as a potential biomarker for diagnosis and prognosis of colorectal cancer
Title: Loss of ZG16 is associated with molecular and clinicopathological phenotypes of colorectal cancer.
Data show that an upstream regulator of zymogen granule protein 16 (ZG16), miR-196a, which was significantly overexpressed in colorectal cancer (CRC) and promotes cell growth and stemness.
Title: Loss of ZG16 is regulated by miR-196a and contributes to stemness and progression of colorectal cancer.
Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p.
Title: Defining the Interaction of Human Soluble Lectin ZG16p and Mycobacterial Phosphatidylinositol Mannosides.
Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system.
Title: Human ZG16p recognizes pathogenic fungi through non-self polyvalent mannose in the digestive system.
the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site.
Title: Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold.
hZG16 was markedly down-regulated in hepatocellular carcinoma (HCC) as indicated by RT-PCR.
Title: hZG16, a novel human secreted protein expressed in liver, was down-regulated in hepatocellular carcinoma.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info
involved_in protein transport	TAS Traceable Author Statement more info	PubMed
involved_in suppression of symbiont entry into host	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi lumen	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in mucus layer	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zymogen granule membrane protein 16

Names: jacalin-like lectin domain containing; secretory lectin ZG16; zymogen granule protein 16 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152338.4 → NP_689551.3 zymogen granule membrane protein 16 precursor

Status: VALIDATED

Source sequence(s)

AC009133, KF456182

Consensus CDS

CCDS54000.1

UniProtKB/Swiss-Prot

B2R4Z3, B9EK72, O60844

Related

ENSP00000383563.4, ENST00000400752.6

Conserved Domains (1) summary

cd09611
Location:36 → 158

Jacalin_ZG16_like; Jacalin-like lectin domain of the zymogen granule protein 16 and related proteins