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MZT2A mitotic spindle organizing protein 2A [ Homo sapiens (human) ]

Gene ID: 653784, updated on 2-Nov-2024

Summary

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Official Symbol
MZT2Aprovided by HGNC
Official Full Name
mitotic spindle organizing protein 2Aprovided by HGNC
Primary source
HGNC:HGNC:33187
See related
Ensembl:ENSG00000173272 MIM:613449; AllianceGenome:HGNC:33187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM128A; MOZART2A
Summary
Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 4.8), colon (RPKM 4.6) and 25 other tissues See more
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Genomic context

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See MZT2A in Genome Data Viewer
Location:
2q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (131469728..131493754, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (131904493..131928522, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (132241533..132249970, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NOC2 like nucleolar associated transcriptional repressor pseudogene 2 Neighboring gene ras homolog family member Q pseudogene 2 Neighboring gene tubulin alpha 3d Neighboring gene hESC enhancers GRCh37_chr2:132249301-132250094 and GRCh37_chr2:132250095-132250888 Neighboring gene microRNA 4784 Neighboring gene sphingomyelin phosphodiesterase 4B, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:132279157-132279881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16534 Neighboring gene coiled-coil domain containing 74A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:132293270-132293826 Neighboring gene mediator complex subunit 15 pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8. Teixidó-Travesa N, et al. Mol Biol Cell, 2010 Nov 15. PMID 20861304, Free PMC Article
  2. MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain. Wang H, et al. Cancer Sci, 2021 Jun. PMID 33754417, Free PMC Article
  3. MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex. Wieczorek M, et al. Cell Rep, 2020 Jun 30. PMID 32610146, Free PMC Article
  4. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. Choi YK, et al. J Cell Biol, 2010 Dec 13. PMID 21135143, Free PMC Article
  5. Expanding the substantial interactome of NEMO using protein microarrays. Fenner BJ, et al. PLoS One, 2010 Jan 20. PMID 20098747, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain.
    Title: MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain.
  2. MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex.
    Title: MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex.
  3. Data show that depletion of GCP8 specifically affects the organization of the interphase microtubule network.
    Title: The gammaTuRC revisited: a comparative analysis of interphase and mitotic human gammaTuRC redefines the set of core components and identifies the novel subunit GCP8.
  4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of gamma-tubulin ring complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
mitotic-spindle organizing protein 2A
Names
family with sequence similarity 128, member A
mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085365.2 → NP_001078834.1  mitotic-spindle organizing protein 2A

    See identical proteins and their annotated locations for NP_001078834.1

    Status: VALIDATED

    Source sequence(s)
    BM554057, BU682101
    Consensus CDS
    CCDS42758.1
    UniProtKB/Swiss-Prot
    Q3SWV8, Q6P582, Q8WVB2
    UniProtKB/TrEMBL
    A0A494C0V9
    Related
    ENSP00000311500.6, ENST00000309451.7
    Conserved Domains (1) summary
    pfam12926
    Location:9 → 96
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    131469728..131493754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445568.1 → XP_047301524.1  mitotic-spindle organizing protein 2A isoform X1

  2. XM_005263742.4 → XP_005263799.2  mitotic-spindle organizing protein 2A isoform X2

    Related
    ENSP00000403353.1, ENST00000427024.5

  3. XM_047445570.1 → XP_047301526.1  mitotic-spindle organizing protein 2A isoform X4

  4. XM_047445569.1 → XP_047301525.1  mitotic-spindle organizing protein 2A isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    131904493..131928522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443952.1 → XP_047299908.1  mitotic-spindle organizing protein 2A isoform X1

  2. XM_054343496.1 → XP_054199471.1  mitotic-spindle organizing protein 2A isoform X6

  3. XM_054343495.1 → XP_054199470.1  mitotic-spindle organizing protein 2A isoform X5

  4. XM_054343498.1 → XP_054199473.1  mitotic-spindle organizing protein 2A isoform X8

  5. XM_054343497.1 → XP_054199472.1  mitotic-spindle organizing protein 2A isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P582.2 GenPept UniProtKB/Swiss-Prot:Q6P582

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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