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ogt.2 O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 652952, updated on 28-Oct-2024

Summary

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Official Symbol
ogt.2provided by ZNC
Official Full Name
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-051128-1
See related
Ensembl:ENSDARG00000099455 AllianceGenome:ZFIN:ZDB-GENE-051128-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ogtb; ogtl
Summary
Enables protein N-acetylglucosaminyltransferase activity. Predicted to be involved in protein glycosylation. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ogt.2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (14687721..14710837, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (14382158..14405227, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene centrin, EF-hand protein, 2 Neighboring gene germ cell nuclear acidic peptidase Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1 Neighboring gene uncharacterized LOC137487515

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis. Sohn KC, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16188232
  2. Sleep deprivation impairs learning and memory by decreasing protein O-GlcNAcylation in the brain of adult zebrafish. Lee Y, et al. FASEB J, 2020 Jan. PMID 31914627
  3. O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development. Webster DM, et al. BMC Dev Biol, 2009 Apr 21. PMID 19383152, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein N-acetylglucosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein O-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2
Names
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 2
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) like
NP_001373727.1
NP_001373728.1
XP_021336805.1
XP_068069340.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386798.1 → NP_001373727.1  O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX323828, CR753843
    Related
    ENSDARP00000130346.2, ENSDART00000159456.2
    Conserved Domains (3) summary
    TIGR02917
    Location:22 → 465
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:327 → 355
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:476 → 1014
    Glyco_transf_41; Glycosyl transferase family 41

  2. NM_001386799.1 → NP_001373728.1  O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX323828, CR753843
    Related
    ENSDARP00000136590.2, ENSDART00000157392.2
    Conserved Domains (3) summary
    TIGR02917
    Location:23 → 455
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:317 → 345
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:466 → 1004
    Glyco_transf_41; Glycosyl transferase family 41

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    14687721..14710837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213239.1 → XP_068069340.1  O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 isoform X1

  2. XM_021481130.2 → XP_021336805.1  O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9QPC9
    Conserved Domains (3) summary
    sd00006
    Location:151 → 179
    TPR; TPR repeat [structural motif]
    pfam13844
    Location:380 → 845
    Glyco_transf_41; Glycosyl transferase family 41
    cl26002
    Location:6 → 289
    TPR_11; TPR repeat
Nucleotide Protein Strain
Heading Accession and Version

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