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map2k6 mitogen-activated protein kinase kinase 6 [ Danio rerio (zebrafish) ]

Gene ID: 65239, updated on 2-Nov-2024

Summary

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Official Symbol
map2k6provided by ZNC
Official Full Name
mitogen-activated protein kinase kinase 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-010202-3
See related
Ensembl:ENSDARG00000099184 AllianceGenome:ZFIN:ZDB-GENE-010202-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MKK3; zMKK3; map2k3
Summary
Predicted to enable MAP kinase kinase activity. Involved in positive regulation of p38MAPK cascade. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See map2k6 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (36109071..36159881)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (36414816..36465626)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 142 Neighboring gene BTB (POZ) domain containing 17a Neighboring gene potassium inwardly rectifying channel subfamily J member 2a Neighboring gene potassium inwardly rectifying channel subfamily J member 16a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mitogen-activated protein kinase kinase 6 is involved in the immune response to bacterial di-/tripeptide challenge in grass carp Ctenopharyngodon idella. Qu F, et al. Fish Shellfish Immunol, 2019 Jan. PMID 30393177
  2. Characteristics of the New Insulin-Resistant Zebrafish Model. Nam YH, et al. Pharmaceuticals (Basel), 2021 Jul 4. PMID 34358068, Free PMC Article
  3. Asymmetric p38 activation in zebrafish: its possible role in symmetric and synchronous cleavage. Fujii R, et al. J Cell Biol, 2000 Sep 18. PMID 10995439, Free PMC Article
  4. Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish. Chou CM, et al. J Biomed Sci, 2015 Nov 17. PMID 26572230, Free PMC Article
  5. Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response. Liu R, et al. Zebrafish, 2020 Apr. PMID 32176570

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 6
NP_001299799.1
XP_068080748.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312870.1 → NP_001299799.1  dual specificity mitogen-activated protein kinase kinase 6

    Status: VALIDATED

    Source sequence(s)
    AL954682, CU467923, DR720420, EH448857
    UniProtKB/Swiss-Prot
    Q6IQW6, Q9DGE0
    Related
    ENSDARP00000141647.1, ENSDART00000171268.2
    Conserved Domains (2) summary
    cd06617
    Location:78 → 360
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    smart00220
    Location:81 → 341
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    36109071..36159881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224647.1 → XP_068080748.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_131724.1: Suppressed sequence

    Description
    NM_131724.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DGE0.2 GenPept UniProtKB/Swiss-Prot:Q9DGE0

Gene LinkOut

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