klf17 Kruppel like factor 17 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf17provided by ZNC
Official Full Name: Kruppel like factor 17provided by ZNC
Primary source: ZFIN:ZDB-GENE-010129-1
See related: Ensembl:ENSDARG00000038792 AllianceGenome:ZFIN:ZDB-GENE-010129-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: klf4; biklf; klf4b; id:ibd5109; wu:fc09b11; zgc:109839; ik:tdsubc_1b8; ik:tdsubc_1e5; xx:tdsubc_1b8; xx:tdsubc_1e5; ik:tdsubc_1e12; xx:tdsubc_1e12
Summary: Enables DNA binding activity. Acts upstream of or within several processes, including erythrocyte differentiation; hatching gland development; and regulation of gene expression. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; germ ring; hematopoietic system; lateral line system; and mesoderm. Orthologous to several human genes including KLF2 (Kruppel like factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (33326537..33328688)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (33343319..33345470)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
Title: Cooperative contributions of the klf1 and klf17 genes in zebrafish primitive erythropoiesis.
Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development.
Title: Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development.
used microarray expression profiles of klf2a, klf2b and klf17 knockdown and overexpression embryos to identify Klf target genes, which reveals that Klfs participate in specification of the extraembryonic enveloping layer
Title: A Pou5f1/Oct4 dependent Klf2a, Klf2b, and Klf17 regulatory sub-network contributes to EVL and ectoderm development during zebrafish embryogenesis.
zKLF4 is expressed within the pre-polster, an early mesendodermal site, and that it plays a critical role in the differentiation of these cells into hatching gland cells.
Title: Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching.

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General gene information

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Markers

fe47b03.y1 (e-PCR)
- UniSTS:196474

fc09b11.x1 (e-PCR)
- UniSTS:192381

fc09b11.x1 (e-PCR)
- UniSTS:192382

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hatching gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info

General protein information

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Preferred Names: Krueppel-like factor 17

Names: Kruppel-like factor 4; Kruppel-like factor 4b; blood island-enriched Kruppel-li; blood island-enriched Kruppel-like factor; etID46628.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131723.1 → NP_571798.1 Krueppel-like factor 17

See identical proteins and their annotated locations for NP_571798.1

Status: PROVISIONAL

Source sequence(s)

AF262978

UniProtKB/TrEMBL

B2GT70, F6NY26, Q9DFS2

Related

ENSDARP00000056654.4, ENSDART00000056655.5

Conserved Domains (4) summary

COG5048
Location:248 → 393

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:331 → 350

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:326 → 350

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:372 → 397

zf-H2C2_2; Zinc-finger double domain