BMP4 bone morphogenetic protein 4 [ Homo sapiens (human) ]

Gene ID: 652, updated on 5-Aug-2026

Summary

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Official Symbol: BMP4provided by HGNC
Official Full Name: bone morphogenetic protein 4provided by HGNC
Primary source: HGNC:HGNC:1071
See related: Ensembl:ENSG00000125378 MIM:112262; AllianceGenome:HGNC:1071
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
Expression: Broad expression in placenta (RPKM 12.6), urinary bladder (RPKM 7.5) and 20 other tissues See more
Orthologs: all
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Genomic context

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See BMP4 in Genome Data Viewer

Location:: 14q22.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (53949736..53956891, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (48157959..48165118, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (54416454..54423609, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bone morphogenetic protein 4 inhibits corneal neovascularization by blocking NETs-induced disruption to corneal epithelial barrier.
Title: Bone morphogenetic protein 4 inhibits corneal neovascularization by blocking NETs-induced disruption to corneal epithelial barrier.
Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis.
Title: Bone morphogenic protein-4 availability in the cardiac microenvironment controls inflammation and fibrosis in autoimmune myocarditis.
Bone Morphogenetic Protein-4 Promotes Phenotypic Modulation via SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells.
Title: Bone Morphogenetic Protein-4 Promotes Phenotypic Modulation via SMAD-4/MCT-4 Axis in Vascular Smooth Muscle Cells.
Expression pattern of the bone morphogenetic protein-4 and its relationship with inflammation, vascular injury in patients suffered the arterial occlusive diseases.
Title: Expression pattern of the bone morphogenetic protein-4 and its relationship with inflammation, vascular injury in patients suffered the arterial occlusive diseases.
BMP4 in Human Endometrial Stromal Cells Can Affect Decidualization by Regulating FOXO1 Expression.
Title: BMP4 in Human Endometrial Stromal Cells Can Affect Decidualization by Regulating FOXO1 Expression.
SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1.
Title: SHH regulates penile morphology and smooth muscle through a mechanism involving BMP4 and GREM1.
BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis.
Title: BMP4 and GREM1 are targets of SHH signaling and downstream regulators of collagen in the penis.
AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling.
Title: AEBP1 promotes papillary thyroid cancer progression by activating BMP4 signaling.
BMP4 up-regulated by 630 nm LED irradiation is associated with the amelioration of rheumatoid arthritis.
Title: BMP4 up-regulated by 630 nm LED irradiation is associated with the amelioration of rheumatoid arthritis.
BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.
Title: BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment.

Submit: New GeneRIF Correction See all GeneRIFs (394)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Anophthalmia-microphthalmia syndrome MedGen: C5680330 GeneReviews: Not available	Compare labs
Microphthalmia with brain and digit anomalies MedGen: C1864689 OMIM: 607932 GeneReviews: Not available	Compare labs
Orofacial cleft 11 MedGen: C2677434 OMIM: 600625 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2025-04-23) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2025-04-23) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association scan of dental caries in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study reveals genetic risk underlying Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BMP4_296 (e-PCR)
- UniSTS:277036

G15892 (e-PCR)
- UniSTS:65077

Bmp4 (e-PCR), detects polymorphism
- UniSTS:532293

SHGC-57004 (e-PCR)
- UniSTS:3192

Bmp4 (e-PCR), detects polymorphism
- UniSTS:506753

RH47295 (e-PCR)
- UniSTS:14466

RH66828 (e-PCR)
- UniSTS:66257

Bmp4 (e-PCR), detects polymorphism
- UniSTS:526068

MARC_5761-5762:996690803:2 (e-PCR)
- UniSTS:269563

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables BMP receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables BMP receptor binding	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
enables co-receptor binding	IEA Inferred from Electronic Annotation more info
enables co-receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in aortic valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in apoptotic process involved in endocardial cushion morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bronchus development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bud dilation involved in lung branching	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in cardiac jelly development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
NOT involved_in cardiac right ventricle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac septum development	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to BMP stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to BMP stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in coronary vasculature development	IEA Inferred from Electronic Annotation more info
involved_in coronary vasculature development	ISS Inferred from Sequence or Structural Similarity more info
involved_in deltoid tuberosity development	IEA Inferred from Electronic Annotation more info
involved_in deltoid tuberosity development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocardial cushion development	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endochondral ossification	IEA Inferred from Electronic Annotation more info
involved_in endochondral ossification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial cell proliferation involved in lung morphogenesis	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in epithelial to mesenchymal transition involved in endocardial cushion formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in epithelial tube branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in glomerular capillary formation	IEA Inferred from Electronic Annotation more info
involved_in glomerular capillary formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart induction	IEA Inferred from Electronic Annotation more info
involved_in heart induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in intermediate mesodermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in lung vasculature development	IEA Inferred from Electronic Annotation more info
involved_in lung vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphoid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in membranous septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in membranous septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mesoderm development	IDA Inferred from Direct Assay more info	PubMed
involved_in mesonephros development	IEP Inferred from Expression Pattern more info	PubMed
involved_in monocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle tissue development	IEA Inferred from Electronic Annotation more info
NOT involved_in muscular septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in myeloid leukocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glomerular mesangial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glomerulus development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mesenchymal cell proliferation involved in ureter development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of metanephric S-shaped body morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of metanephric comma-shaped body morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of miRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitotic nuclear division	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of striated muscle tissue development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of thymocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular associated smooth muscle cell migration	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of vascular associated smooth muscle cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in nephric duct formation	IDA Inferred from Direct Assay more info	PubMed
involved_in odontogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in outflow tract septum morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in pharyngeal arch artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pharyngeal arch artery morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of branching involved in lung morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of branching involved in lung morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cartilage development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of odontoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of odontoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of p38MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of primary miRNA processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within post-embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in pulmonary valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in pulmonary valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in secondary heart field specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sinoatrial node development	NAS Non-traceable Author Statement more info	PubMed
involved_in smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed
involved_in smooth muscle tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within telencephalon development	IDA Inferred from Direct Assay more info	PubMed
involved_in telencephalon development	IEA Inferred from Electronic Annotation more info
involved_in tendon cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in tendon cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within trachea development	IDA Inferred from Direct Assay more info	PubMed
involved_in type B pancreatic cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in ureter morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureteric bud development	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: bone morphogenetic protein 4

Names: bone morphogenetic protein 2B

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009215.1 RefSeqGene

Range

5012..12101

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202.6 → NP_001193.2 bone morphogenetic protein 4 isoform a preproprotein

See identical proteins and their annotated locations for NP_001193.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) uses the P1 promoter and encodes isoform a.

Source sequence(s)

AL138479, BU683974, BX161385, M22490

Consensus CDS

CCDS9715.1

UniProtKB/Swiss-Prot

P12644, Q9UM80

UniProtKB/TrEMBL

Q53XC5

Related

ENSP00000245451.4, ENST00000245451.9

Conserved Domains (2) summary

smart00204
Location:308 → 408

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:41 → 275

TGFb_propeptide; TGF-beta propeptide
NM_001347912.1 → NP_001334841.1 bone morphogenetic protein 4 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains two alternate splice sites and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) has a distinct and longer N-terminus, compared to isoform a.

Source sequence(s)

AL138479, BE877424
NM_001347913.2 → NP_001334842.1 bone morphogenetic protein 4 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.

Source sequence(s)

AL138479
NM_001347914.2 → NP_001334843.1 bone morphogenetic protein 4 isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate promoter and differs in the 5' UTR compared to variant 1.

Source sequence(s)

AL138479, BX161385

Consensus CDS

CCDS9715.1

UniProtKB/Swiss-Prot

P12644, Q9UM80

UniProtKB/TrEMBL

Q53XC5

Related

ENSP00000454134.1, ENST00000558984.2
NM_001347915.2 → NP_001334844.1 bone morphogenetic protein 4 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate promoter, differs in the 5' UTR, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.

Source sequence(s)

AL138479
NM_001347916.1 → NP_001334845.1 bone morphogenetic protein 4 isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1.

Source sequence(s)

AL138479

Consensus CDS

CCDS9715.1

UniProtKB/Swiss-Prot

P12644, Q9UM80

UniProtKB/TrEMBL

Q53XC5

Related

ENSP00000560866.1, ENST00000890807.1
NM_001347917.1 → NP_001334846.1 bone morphogenetic protein 4 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.

Source sequence(s)

AL138479
NM_130850.5 → NP_570911.2 bone morphogenetic protein 4 isoform a preproprotein

See identical proteins and their annotated locations for NP_570911.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AL138479

Consensus CDS

CCDS9715.1

UniProtKB/Swiss-Prot

P12644, Q9UM80

UniProtKB/TrEMBL

Q53XC5

Related

ENSP00000453485.1, ENST00000559087.6

Conserved Domains (2) summary

smart00204
Location:308 → 408

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:41 → 275

TGFb_propeptide; TGF-beta propeptide
NM_130851.4 → NP_570912.2 bone morphogenetic protein 4 isoform a preproprotein

See identical proteins and their annotated locations for NP_570912.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses the P2 promoter and differs in the 5' UTR compared to variant 1.

Source sequence(s)

AL138479, BU683974, BX161385

UniProtKB/Swiss-Prot

P12644, Q9UM80

UniProtKB/TrEMBL

Q53XC5

Related

ENSP00000394165.1, ENST00000417573.5