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Amotl2 angiomotin like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65157, updated on 28-Oct-2024

Summary

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Official Symbol
Amotl2provided by RGD
Official Full Name
angiomotin like 2provided by RGD
Primary source
RGD:70977
See related
EnsemblRapid:ENSRNOG00000008487 AllianceGenome:RGD:70977
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lccp
Summary
Predicted to enable actin filament binding activity and identical protein binding activity. Predicted to be involved in several processes, including endothelial cell morphogenesis; establishment of cell polarity involved in ameboidal cell migration; and hippo signaling. Predicted to be located in several cellular components, including apical plasma membrane; cell junction; and podosome. Predicted to be active in bicellular tight junction; cytoplasmic vesicle; and plasma membrane. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 426.0), Kidney (RPKM 294.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amotl2 in Genome Data Viewer
Location:
8q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112182060..112198032)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103303368..103319161)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111210261..111226217)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 63 Neighboring gene uncharacterized LOC134480096 Neighboring gene anaphase promoting complex subunit 13 Neighboring gene receptor-like tyrosine kinase Neighboring gene uncharacterized LOC102549824

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling. Deng J, et al. J Cardiovasc Pharmacol, 2024 Sep 1. PMID 39027975
  2. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Patrie KM. Biochim Biophys Acta, 2005 Aug 15. PMID 16019084
  3. Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. Bratt A, et al. Gene, 2002 Sep 18. PMID 12406577
  4. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Sugihara-Mizuno Y, et al. Genes Cells, 2007 Apr. PMID 17397395
  5. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Zhao B, et al. Genes Dev, 2011 Jan 1. PMID 21205866, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.
    Title: Upregulation of Angiomotin-Like 2 Ameliorates Experimental Pulmonary Arterial Hypertension by Inactivating YAP1 Signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  
located_in podosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
angiomotin-like protein 2
Names
Leman coiled-coil protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031717.1 → NP_113905.1  angiomotin-like protein 2

    See identical proteins and their annotated locations for NP_113905.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/Swiss-Prot
    G3V735
    UniProtKB/TrEMBL
    A0A0G2KAV3
    Related
    ENSRNOP00000075540.2, ENSRNOT00000090221.3
    Conserved Domains (2) summary
    COG1196
    Location:300 → 577
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:477 → 679
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    112182060..112198032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243680.5 → XP_006243742.1  angiomotin-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAV3, A0A8I6AGR3
    Related
    ENSRNOP00000093935.1, ENSRNOT00000094404.2
    Conserved Domains (1) summary
    pfam12240
    Location:500 → 701
    Angiomotin_C; Angiomotin C terminal

  2. XM_039082102.2 → XP_038938030.1  angiomotin-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    G3V735
    UniProtKB/TrEMBL
    A0A0G2KAV3
    Conserved Domains (2) summary
    COG1196
    Location:300 → 577
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:477 → 679
    Angiomotin_C; Angiomotin C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3V735.1 GenPept UniProtKB/Swiss-Prot:G3V735

Gene LinkOut

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