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Dap3 death associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 65111, updated on 28-Oct-2024

Summary

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Official Symbol
Dap3provided by MGI
Official Full Name
death associated protein 3provided by MGI
Primary source
MGI:MGI:1929538
See related
Ensembl:ENSMUSG00000068921 AllianceGenome:MGI:1929538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAP-3; S29mt; MRP-S29; 4921514D13Rik
Summary
Predicted to be a structural constituent of ribosome. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and sensory organ. Orthologous to human DAP3 (death associated protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 20.1), placenta adult (RPKM 12.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dap3 in Genome Data Viewer
Location:
3 F1; 3 39.01 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88828110..88858504, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88920803..88951213, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene gon-4 like Neighboring gene nuclear encoded rRNA 5S 197 Neighboring gene misato 1, mitochondrial distribution and morphology regulator Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_08222 Neighboring gene predicted gene, 26465 Neighboring gene predicted gene, 24403

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Death-associated protein 3 regulates cellular senescence through oxidative stress response. Murata Y, et al. FEBS Lett, 2006 Nov 13. PMID 17056041
  2. Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. Tosa N, et al. Biochem Biophys Res Commun, 2010 May 7. PMID 20381457
  3. Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death. Mukamel Z, et al. J Biol Chem, 2004 Aug 27. PMID 15175341
  4. Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis. Kim HR, et al. FASEB J, 2007 Jan. PMID 17135360
  5. Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics. Xiao L, et al. J Biol Chem, 2015 Oct 9. PMID 26306039, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DAP3 plays important roles in mitochondrial function and dynamics
    Title: Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.
  2. DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77.
    Title: Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction.
  3. requirement for DAP3 in mitochondrial respiration was also revealed by oxygen consumption measurements using cultured cells treated with DAP3-specific small interfering RNA
    Title: Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosis.
  4. DAP3 has a role in the molecular pathway that culminates in fragmented mitochondria
    Title: Death-associated protein 3 localizes to the mitochondria and is involved in the process of mitochondrial fragmentation during cell death.
  5. DAP3 is reduced in both replicative and premature senescence induced by oxidative stress, and the DAP3 reduction induced by oxidative stress is observed mostly in a mitochondrial fraction.
    Title: Death-associated protein 3 regulates cellular senescence through oxidative stress response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS29
Names
28S ribosomal protein S29, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164533.1 → NP_001158005.1  small ribosomal subunit protein mS29 isoform 1

    See identical proteins and their annotated locations for NP_001158005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC127377, AK014280, AV340314, CD741520
    Consensus CDS
    CCDS50955.1
    UniProtKB/TrEMBL
    A0A0R4J1B9
    Related
    ENSMUSP00000103115.5, ENSMUST00000107491.11
    Conserved Domains (1) summary
    pfam10236
    Location:97 → 362
    DAP3; Mitochondrial ribosomal death-associated protein 3

  2. NM_001368419.1 → NP_001355348.1  small ribosomal subunit protein mS29 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127377
    Consensus CDS
    CCDS89651.1
    UniProtKB/Swiss-Prot
    Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
    Conserved Domains (1) summary
    pfam10236
    Location:92 → 387
    DAP3; Mitochondrial ribosomal death-associated protein 3

  3. NM_022994.3 → NP_075370.2  small ribosomal subunit protein mS29 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC127377, AJ250375, AV340314
    Consensus CDS
    CCDS17486.2
    UniProtKB/TrEMBL
    G3X9M0
    Related
    ENSMUSP00000088456.5, ENSMUST00000090938.11
    Conserved Domains (1) summary
    pfam10236
    Location:97 → 392
    DAP3; Mitochondrial ribosomal death-associated protein 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88828110..88858504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501863.5 → XP_006501926.1  small ribosomal subunit protein mS29 isoform X1

    See identical proteins and their annotated locations for XP_006501926.1

    UniProtKB/Swiss-Prot
    Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
    Conserved Domains (1) summary
    pfam10236
    Location:92 → 387
    DAP3; Mitochondrial ribosomal death-associated protein 3

  2. XM_006501864.3 → XP_006501927.1  small ribosomal subunit protein mS29 isoform X1

    See identical proteins and their annotated locations for XP_006501927.1

    UniProtKB/Swiss-Prot
    Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
    Related
    ENSMUSP00000134422.2, ENSMUST00000173135.8
    Conserved Domains (1) summary
    pfam10236
    Location:92 → 387
    DAP3; Mitochondrial ribosomal death-associated protein 3

  3. XM_006501869.5 → XP_006501932.1  small ribosomal subunit protein mS29 isoform X1

    See identical proteins and their annotated locations for XP_006501932.1

    UniProtKB/Swiss-Prot
    Q8C2B2, Q8CCQ8, Q8VCK8, Q9CRT4, Q9CS11, Q9D5V9, Q9ER88
    Conserved Domains (1) summary
    pfam10236
    Location:92 → 387
    DAP3; Mitochondrial ribosomal death-associated protein 3

  4. XM_006501865.4 → XP_006501928.1  small ribosomal subunit protein mS29 isoform X3

    Conserved Domains (1) summary
    pfam10236
    Location:97 → 339
    DAP3; Mitochondrial ribosomal death-associated protein 3

  5. XM_030252745.1 → XP_030108605.1  small ribosomal subunit protein mS29 isoform X2

    Conserved Domains (1) summary
    pfam10236
    Location:92 → 357
    DAP3; Mitochondrial ribosomal death-associated protein 3

  6. XM_036163214.1 → XP_036019107.1  small ribosomal subunit protein mS29 isoform X8

    Conserved Domains (1) summary
    pfam10236
    Location:92 → 304
    DAP3; Mitochondrial ribosomal death-associated protein 3

  7. XM_006501868.5 → XP_006501931.1  small ribosomal subunit protein mS29 isoform X9

    Conserved Domains (1) summary
    pfam10236
    Location:97 → 282
    DAP3; Mitochondrial ribosomal death-associated protein 3

  8. XM_006501866.5 → XP_006501929.1  small ribosomal subunit protein mS29 isoform X6

    Conserved Domains (1) summary
    pfam10236
    Location:97 → 312
    DAP3; Mitochondrial ribosomal death-associated protein 3

  9. XM_030252747.1 → XP_030108607.1  small ribosomal subunit protein mS29 isoform X7

    Conserved Domains (1) summary
    pfam10236
    Location:92 → 307
    DAP3; Mitochondrial ribosomal death-associated protein 3

  10. XM_036163212.1 → XP_036019105.1  small ribosomal subunit protein mS29 isoform X4

    Conserved Domains (1) summary
    pfam10236
    Location:92 → 334
    DAP3; Mitochondrial ribosomal death-associated protein 3

  11. XM_006501867.4 → XP_006501930.1  small ribosomal subunit protein mS29 isoform X5

    Conserved Domains (1) summary
    pfam10236
    Location:97 → 309
    DAP3; Mitochondrial ribosomal death-associated protein 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ER88.1 GenPept UniProtKB/Swiss-Prot:Q9ER88

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