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NOL6 nucleolar protein 6 [ Homo sapiens (human) ]

Gene ID: 65083, updated on 7-Apr-2024

Summary

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Official Symbol
NOL6provided by HGNC
Official Full Name
nucleolar protein 6provided by HGNC
Primary source
HGNC:HGNC:19910
See related
Ensembl:ENSG00000165271 MIM:611532; AllianceGenome:HGNC:19910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRAP; UTP22; bA311H10.1
Summary
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 9.6), skin (RPKM 6.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See NOL6 in Genome Data Viewer
Location:
9p13.3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33461353..33473924, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33479851..33492421, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33461351..33473922, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene aquaporin 7 Neighboring gene Sharpr-MPRA regulatory region 4081 Neighboring gene uncharacterized LOC105376020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33404334-33404891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33407721-33408222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33408223-33408722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33414572-33415103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33415104-33415634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:33435285-33435786 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:33438678-33438916 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:33442744-33443943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19834 Neighboring gene Sharpr-MPRA regulatory region 5008 Neighboring gene aquaporin 3 (Gill blood group) Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:33458152-33459351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28297 Neighboring gene uncharacterized LOC107987061 Neighboring gene microRNA 6851 Neighboring gene SUGT1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma. Meng L, et al. Chin Med J (Engl), 2021 Sep 21. PMID 34561331, Free PMC Article
  2. NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression. Liang J, et al. Epigenomics, 2021 Oct. PMID 34607487
  3. Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans. Utama B, et al. Genes Cells, 2002 Feb. PMID 11895476
  4. RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis. Farooq M, et al. Nat Commun, 2020 Nov 16. PMID 33199730, Free PMC Article
  5. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. Matafora V, et al. Mol Cell Proteomics, 2009 Oct. PMID 19596686, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression.
    Title: NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression.
  2. Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.
    Title: Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21959, MGC14896, MGC14921, MGC20838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CURI complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of UTP-C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed nuclear chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleolar protein 6
Names
nucleolar RNA-associated protein
nucleolar protein 6 (RNA-associated)
nucleolar protein family 6 (RNA-associated)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022917.5 → NP_075068.2  nucleolar protein 6 isoform alpha

    See identical proteins and their annotated locations for NP_075068.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (alpha) encodes the longest isoform (alpha), also known as the long isoform.
    Source sequence(s)
    AF361079, BC008852, CB267269
    Consensus CDS
    CCDS6543.1
    UniProtKB/Swiss-Prot
    Q5T5M3, Q5T5M4, Q7L4G6, Q8N6I0, Q8TEY9, Q8TEZ0, Q8TEZ1, Q9H675, Q9H6R4
    UniProtKB/TrEMBL
    B4DF80
    Related
    ENSP00000297990.4, ENST00000297990.9
    Conserved Domains (6) summary
    pfam03813
    Location:178 → 320
    Nrap; Nrap protein domain 1
    pfam17403
    Location:323 → 463
    Nrap_D2; Nrap protein PAP/OAS-like domain
    pfam17404
    Location:466 → 629
    Nrap_D3; Nrap protein domain 3
    pfam17405
    Location:641 → 846
    Nrap_D4; Nrap protein nucleotidyltransferase domain 4
    pfam17406
    Location:848 → 1003
    Nrap_D5; Nrap protein PAP/OAS1-like domain 5
    pfam17407
    Location:1005 → 1137
    Nrap_D6; Nrap protein domain 6

  2. NM_139235.4 → NP_631981.2  nucleolar protein 6 isoform gamma

    See identical proteins and their annotated locations for NP_631981.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (gamma) lacks nine exons in the 3' region compared to variant alpha. The encoded isoform (gamma), also known as the short isoform, has a unique C-terminus compared to the alpha isoform.
    Source sequence(s)
    AF361081, BC008852, CB267269
    Consensus CDS
    CCDS6544.1
    UniProtKB/Swiss-Prot
    Q9H6R4
    Related
    ENSP00000313978.4, ENST00000353159.6
    Conserved Domains (1) summary
    pfam03813
    Location:165 → 654
    Nrap; Nrap protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    33461353..33473924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423740.1 → XP_047279696.1  nucleolar protein 6 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    33479851..33492421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363572.1 → XP_054219547.1  nucleolar protein 6 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_130793.3: Suppressed sequence

    Description
    NM_130793.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6R4.2 GenPept UniProtKB/Swiss-Prot:Q9H6R4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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