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CDK15 cyclin dependent kinase 15 [ Homo sapiens (human) ]

Gene ID: 65061, updated on 5-Mar-2024

Summary

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Official Symbol
CDK15provided by HGNC
Official Full Name
cyclin dependent kinase 15provided by HGNC
Primary source
HGNC:HGNC:14434
See related
Ensembl:ENSG00000138395 MIM:616147; AllianceGenome:HGNC:14434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFTK2; ALS2CR7; PFTAIRE2
Summary
Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues See more
Orthologs
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Genomic context

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Location:
2q33.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (201806429..201895550)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (202287333..202376437)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202671152..202760273)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 651, pseudogene Neighboring gene MAGUK p55 scaffold protein 4 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202563997-202564498 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202564499-202564998 Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16994 Neighboring gene ribosomal protein S2 pseudogene 16 Neighboring gene MPRA-validated peak4013 silencer Neighboring gene UBE2V1 pseudogene 11 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:202766463-202767186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12237 Neighboring gene RNA, U6 small nuclear 440, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202813665-202814208 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202814209-202814750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202827374-202827874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202827875-202828375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16995 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:202835024-202835222 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202838433-202839337 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202860883-202861447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202863716-202864219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202864220-202864722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:202885061-202885586 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:202887293-202888158 Neighboring gene Sharpr-MPRA regulatory region 624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:202899462-202900302 Neighboring gene frizzled class receptor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway. Huang C, et al. Cell Death Differ, 2022 Jan. PMID 34262144, Free PMC Article
  2. Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer. Zhang X, et al. J Int Med Res, 2021 Jun. PMID 34162268, Free PMC Article
  3. ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34. Park MH, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24866247
  4. Mammalian cyclin-dependent kinases. Malumbres M, et al. Trends Biochem Sci, 2005 Nov. PMID 16236519
  5. Cyclin-dependent kinases: a family portrait. Malumbres M, et al. Nat Cell Biol, 2009 Nov. PMID 19884882, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating beta-catenin/ MEK-ERK signaling pathway.
    Title: CDK15 promotes colorectal cancer progression via phosphorylating PAK4 and regulating β-catenin/ MEK-ERK signaling pathway.
  2. Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer.
    Title: Cyclin-dependent kinase 15 upregulation is correlated with poor prognosis for patients with breast cancer.
  3. In summary, our results suggest that ALS2CR7 confers TRAIL resistance to cancer cells via phosphorylation of survivin.
    Title: ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 15
Names
PFTAIRE protein kinase 2
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein
cell division protein kinase 15
serine/threonine protein kinase
serine/threonine-protein kinase ALS2CR7
serine/threonine-protein kinase PFTAIRE-2
NP_001248364.1
NP_001248365.1
NP_001353315.1
NP_631897.1
XP_011509952.1
XP_011509954.1
XP_011509956.1
XP_011509957.1
XP_011509958.1
XP_011509959.1
XP_047301508.1
XP_047301509.1
XP_054199420.1
XP_054199421.1
XP_054199422.1
XP_054199423.1
XP_054199424.1
XP_054199425.1
XP_054199426.1
XP_054199427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261435.1 → NP_001248364.1  cyclin-dependent kinase 15 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC007242, AC007358, BX647394, DA050598
    Consensus CDS
    CCDS58747.1
    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000406472.2, ENST00000450471.6
    Conserved Domains (2) summary
    PLN00009
    Location:103 → 390
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:102 → 387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  2. NM_001261436.1 → NP_001248365.1  cyclin-dependent kinase 15 isoform 2

    See identical proteins and their annotated locations for NP_001248365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC038807, DA050598
    Consensus CDS
    CCDS58746.1
    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000412775.1, ENST00000434439.1
    Conserved Domains (2) summary
    PLN00009
    Location:103 → 390
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:102 → 387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  3. NM_001366386.2 → NP_001353315.1  cyclin-dependent kinase 15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007242, AC007358
    Consensus CDS
    CCDS92927.1
    UniProtKB/Swiss-Prot
    A8K8R9, B8ZZX0, C9J1N8, C9K003, F8W6H8, Q4ZG86, Q53TV1, Q6ZMR9, Q8IUP1, Q96Q40
    Related
    ENSP00000498608.2, ENST00000652192.3
    Conserved Domains (1) summary
    cd07870
    Location:102 → 387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  4. NM_139158.2 → NP_631897.1  cyclin-dependent kinase 15 isoform 3

    See identical proteins and their annotated locations for NP_631897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate in-frame 5' exon and initiates translation at an upstream AUG compared to variant 1. This results in a shorter protein (isoform 3) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB053308, AC007242, AC007358
    Consensus CDS
    CCDS2350.1
    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000260967.2, ENST00000260967.6
    Conserved Domains (2) summary
    PLN00009
    Location:52 → 339
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:51 → 336
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    201806429..201895550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511652.2 → XP_011509954.1  cyclin-dependent kinase 15 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:103 → 338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:102 → 367
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011511650.3 → XP_011509952.1  cyclin-dependent kinase 15 isoform X1

    Conserved Domains (2) summary
    PLN00009
    Location:103 → 390
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:102 → 387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

  3. XM_047445552.1 → XP_047301508.1  cyclin-dependent kinase 15 isoform X3

  4. XM_011511654.3 → XP_011509956.1  cyclin-dependent kinase 15 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:102 → 338
    PKc_like; Protein Kinases, catalytic domain

  5. XM_047445553.1 → XP_047301509.1  cyclin-dependent kinase 15 isoform X5

  6. XM_011511656.3 → XP_011509958.1  cyclin-dependent kinase 15 isoform X6

    See identical proteins and their annotated locations for XP_011509958.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 207
    PKc_like; Protein Kinases, catalytic domain

  7. XM_011511655.3 → XP_011509957.1  cyclin-dependent kinase 15 isoform X6

    See identical proteins and their annotated locations for XP_011509957.1

    Conserved Domains (1) summary
    cl21453
    Location:1 → 207
    PKc_like; Protein Kinases, catalytic domain

  8. XM_011511657.3 → XP_011509959.1  cyclin-dependent kinase 15 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:12 → 197
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_922991.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    202287333..202376437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343446.1 → XP_054199421.1  cyclin-dependent kinase 15 isoform X2

  2. XM_054343445.1 → XP_054199420.1  cyclin-dependent kinase 15 isoform X1

  3. XM_054343447.1 → XP_054199422.1  cyclin-dependent kinase 15 isoform X3

  4. XM_054343448.1 → XP_054199423.1  cyclin-dependent kinase 15 isoform X4

  5. XM_054343449.1 → XP_054199424.1  cyclin-dependent kinase 15 isoform X5

  6. XM_054343451.1 → XP_054199426.1  cyclin-dependent kinase 15 isoform X6

  7. XM_054343450.1 → XP_054199425.1  cyclin-dependent kinase 15 isoform X6

  8. XM_054343452.1 → XP_054199427.1  cyclin-dependent kinase 15 isoform X7

RNA

  1. XR_008486494.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96Q40.2 GenPept UniProtKB/Swiss-Prot:Q96Q40

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