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Aqp9 aquaporin 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65054, updated on 2-Nov-2024

Summary

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Official Symbol
Aqp9provided by RGD
Official Full Name
aquaporin 9provided by RGD
Primary source
RGD:68433
See related
EnsemblRapid:ENSRNOG00000061883 AllianceGenome:RGD:68433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including nucleobase transmembrane transporter activity; urea transmembrane transporter activity; and water channel activity. Involved in several processes, including canalicular bile acid transport; nucleobase transport; and response to pain. Located in basolateral plasma membrane. Orthologous to human AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 685.9) and Testes (RPKM 41.9) See more
Orthologs
human mouse all
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Genomic context

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See Aqp9 in Genome Data Viewer
Location:
8q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (80678027..80718273, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (71797231..71837485, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (77559621..77599781, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene HCLS1 associated protein X-1, pseudogene 5 Neighboring gene aldehyde dehydrogenase 1 family, member A2 Neighboring gene uncharacterized LOC134480072

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Maternal Protein Restriction Modulates Angiogenesis and AQP9 Expression Leading to a Delay in Postnatal Epididymal Development in Rat. de Mello Santos T, et al. Cells, 2019 Sep 17. PMID 31533210, Free PMC Article
  2. Cloning and functional expression of rAOP9L a new member of aquaporin family from rat liver. Ko SB, et al. Biochem Mol Biol Int, 1999 Feb. PMID 10205677
  3. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Pastor-Soler N, et al. Biol Reprod, 2002 Jun. PMID 12021052
  4. Aquaglyceroporin AQP9: solute permeation and metabolic control of expression in liver. Carbrey JM, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12594337, Free PMC Article
  5. Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium. Brañes MC, et al. Am J Physiol Cell Physiol, 2005 May. PMID 15647391

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA MALAT1 promotes neuropathic pain progression through the miR1545p/AQP9 axis in CCI rat models.
    Title: LncRNA MALAT1 promotes neuropathic pain progression through the miR‑154‑5p/AQP9 axis in CCI rat models.
  2. The maternal low-protein diet decreased AQP9 and VEGFr-2 expression, decreased epididymal microvascularity and altered the morphometric features of the epididymal epithelium.
    Title: Maternal Protein Restriction Modulates Angiogenesis and AQP9 Expression Leading to a Delay in Postnatal Epididymal Development in Rat.
  3. the combination of AQP9 gene knock-down and U0126 showed no further effect. Silencing AQP9 gene can inhibit the activation of ERK1/2 signaling pathway, attenuate the inflammatory response in rats with MI, inhibit apoptosis of myocardial cells, and improve cardiac function
    Title: Regulation mechanism of aquaporin 9 gene on inflammatory response and cardiac function in rats with myocardial infarction through extracellular signal-regulated kinase1/2 pathway.
  4. that the overexpression of miR-212 inhibited AQP9 by activating the PI3K/Akt signaling pathway, thus decreasing cardiomyocytes apoptosis, promoting vascular regeneration and alleviating ventricular remodeling
    Title: microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signaling pathway.
  5. Downregulation of aquaporin 9 exacerbates beta-amyloid-induced neurotoxicity in Alzheimer's disease models in vitro and in vivo.
    Title: Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer's Disease Models In vitro and In vivo.
  6. The upregulation of AQP9 could be involved in gluconeogenesis and co-regulated by the JNK and p38 MAPK pathway in both Types 1 and 2 DM.
    Title: Similar Aquaporin9 and MAPK Expression Profiles in the Liver of Types 1 and 2 Diabetes Mellitus.
  7. AQP9 expression is increased slowly and reached a peak on day 14 in optic nerve after crushing.
    Title: Changes in expression of aquaporin-4 and aquaporin-9 in optic nerve after crushing in rats.
  8. dynamic changes in AQP9 expression, mediated in part via the p38 MAPK signal transduction pathway, may contribute to the development of cerebral oedema after brain ischaemia.
    Title: Phosphorylation of p38 MAPK mediates aquaporin 9 expression in rat brains during permanent focal cerebral ischaemia.
  9. we suggest that AQP9 is involved in viral tropism and pathogenesis of Herpes simplex encephalitis
    Title: The anterior commissure is a pathway for contralateral spread of herpes simplex virus type 1 after olfactory tract infection.
  10. Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator.
    Title: Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93419

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycerol channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol channel activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerol channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables polyol transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables purine nucleobase transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrimidine nucleobase transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urea channel activity ISO
Inferred from Sequence Orthology
more info
  
enables urea channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables urea transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urea transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in canalicular bile acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in glycerol transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in polyol transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleobase transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleobase transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine-containing compound transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to osmotic stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in urea transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in urea transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in water transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in water transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
aquaporin-9
Names
AQP-9
aquaglyceroporin-9
neutral solute channel aquaporin 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022960.2 → NP_075249.1  aquaporin-9

    See identical proteins and their annotated locations for NP_075249.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085731
    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Related
    ENSRNOP00000069377.1, ENSRNOT00000087980.3
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    80678027..80718273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082097.2 → XP_038938025.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  2. XM_006243362.3 → XP_006243424.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_006243424.1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  3. XM_063266084.1 → XP_063122154.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7

  4. XM_039082095.2 → XP_038938023.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Related
    ENSRNOP00000103858.1, ENSRNOT00000142448.1
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  5. XM_039082099.2 → XP_038938027.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  6. XM_039082096.2 → XP_038938024.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  7. XM_063266082.1 → XP_063122152.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7

  8. XM_039082100.2 → XP_038938028.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7, A6KER9
    Conserved Domains (1) summary
    cl00200
    Location:4 → 266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

  9. XM_063266083.1 → XP_063122153.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7

  10. XM_063266086.1 → XP_063122156.1  aquaporin-9 isoform X2

  11. XM_063266081.1 → XP_063122151.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7

  12. XM_063266085.1 → XP_063122155.1  aquaporin-9 isoform X1

    UniProtKB/Swiss-Prot
    O88815, P56627
    UniProtKB/TrEMBL
    A6KER7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56627.1 GenPept UniProtKB/Swiss-Prot:P56627

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