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RANBP17 RAN binding protein 17 [ Homo sapiens (human) ]

Gene ID: 64901, updated on 3-Apr-2024

Summary

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Official Symbol
RANBP17provided by HGNC
Official Full Name
RAN binding protein 17provided by HGNC
Primary source
HGNC:HGNC:14428
See related
Ensembl:ENSG00000204764 MIM:606141; AllianceGenome:HGNC:14428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Expression
Broad expression in testis (RPKM 1.6), thyroid (RPKM 0.5) and 15 other tissues See more
Orthologs
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Genomic context

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See RANBP17 in Genome Data Viewer
Location:
5q35.1
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (170862018..171300015)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (171402331..171840355)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (170289022..170727019)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170178216-170179100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170179101-170179985 Neighboring gene uncharacterized LOC107986474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170186375-170186905 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170189029-170189559 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170193927-170194791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170194792-170195655 Neighboring gene uncharacterized LOC107986475 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi Neighboring gene RNA, 7SL, cytoplasmic 623, pseudogene Neighboring gene tubulin epsilon 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170329817-170330318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170330319-170330818 Neighboring gene VISTA enhancer hs608 Neighboring gene VISTA enhancer hs693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170516153-170516720 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170530424-170531252 Neighboring gene uncharacterized LOC124901133 Neighboring gene VISTA enhancer hs278 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:170666590-170667789 Neighboring gene uncharacterized LOC124901217 Neighboring gene USP12 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:170720541-170721740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170734859-170735743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170735744-170736629 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170736630-170737514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170737515-170738400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170740171-170741055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:170743669-170744244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170744245-170744819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170744820-170745394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:170745395-170745969 Neighboring gene ribosomal protein L19 pseudogene 10 Neighboring gene T cell leukemia homeobox 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC. Mandic R, et al. BMC Cancer, 2022 Jul 18. PMID 35850701, Free PMC Article
  2. Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12. Lee JH, et al. J Cell Biochem, 2010 Sep 1. PMID 20503194, Free PMC Article
  3. Identification of a novel putative Ran-binding protein and its close homologue. Koch P, et al. Biochem Biophys Res Commun, 2000 Nov 11. PMID 11071879
  4. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. Kutay U, et al. J Biol Chem, 2000 Dec 22. PMID 11024021
  5. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, et al. Nat Commun, 2021 Feb 26. PMID 33637726, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.
    Title: The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC.
  2. These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17.
    Title: Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of RAN binding protein 17 (RANBP17) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables nuclear export signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ran-binding protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022897.5 → NP_075048.1  ran-binding protein 17

    See identical proteins and their annotated locations for NP_075048.1

    Status: VALIDATED

    Source sequence(s)
    AC091980, AJ271459, DC404010
    Consensus CDS
    CCDS34287.1
    UniProtKB/Swiss-Prot
    Q8IU74, Q9H2T7
    UniProtKB/TrEMBL
    Q546R4
    Related
    ENSP00000427975.1, ENST00000523189.6
    Conserved Domains (1) summary
    pfam03810
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    170862018..171300015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534627.2 → XP_011532929.1  ran-binding protein 17 isoform X1

    Conserved Domains (1) summary
    pfam03810
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain

  2. XM_017009738.2 → XP_016865227.1  ran-binding protein 17 isoform X4

  3. XM_017009739.2 → XP_016865228.1  ran-binding protein 17 isoform X5

  4. XM_017009736.2 → XP_016865225.1  ran-binding protein 17 isoform X2

  5. XM_047417530.1 → XP_047273486.1  ran-binding protein 17 isoform X3

  6. XM_017009740.2 → XP_016865229.1  ran-binding protein 17 isoform X6

  7. XM_017009741.3 → XP_016865230.1  ran-binding protein 17 isoform X7

  8. XM_017009742.3 → XP_016865231.1  ran-binding protein 17 isoform X8

  9. XM_017009744.2 → XP_016865233.1  ran-binding protein 17 isoform X9

  10. XM_047417531.1 → XP_047273487.1  ran-binding protein 17 isoform X9

  11. XM_047417532.1 → XP_047273488.1  ran-binding protein 17 isoform X11

  12. XM_011534636.3 → XP_011532938.1  ran-binding protein 17 isoform X12

    UniProtKB/TrEMBL
    Q658U9
    Related
    ENSP00000429298.1, ENST00000519256.5
    Conserved Domains (1) summary
    pfam03810
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain

  13. XM_011534637.3 → XP_011532939.1  ran-binding protein 17 isoform X14

    UniProtKB/TrEMBL
    Q658U9
    Related
    ENSP00000373770.4, ENST00000389118.8
    Conserved Domains (1) summary
    pfam03810
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain

  14. XM_017009746.3 → XP_016865235.1  ran-binding protein 17 isoform X13

    UniProtKB/TrEMBL
    Q658U9, Q8IVM9
    Related
    ENSP00000430958.1, ENST00000522066.5
    Conserved Domains (1) summary
    pfam03810
    Location:30 → 95
    IBN_N; Importin-beta N-terminal domain

  15. XM_017009745.2 → XP_016865234.1  ran-binding protein 17 isoform X10

  16. XM_047417533.1 → XP_047273489.1  ran-binding protein 17 isoform X15

  17. XM_017009747.2 → XP_016865236.1  ran-binding protein 17 isoform X16

RNA

  1. XR_007058628.1 RNA Sequence

  2. XR_941108.3 RNA Sequence

  3. XR_007058630.1 RNA Sequence

  4. XR_007058629.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    171402331..171840355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353158.1 → XP_054209133.1  ran-binding protein 17 isoform X1

  2. XM_054353161.1 → XP_054209136.1  ran-binding protein 17 isoform X4

  3. XM_054353162.1 → XP_054209137.1  ran-binding protein 17 isoform X5

  4. XM_054353159.1 → XP_054209134.1  ran-binding protein 17 isoform X2

  5. XM_054353160.1 → XP_054209135.1  ran-binding protein 17 isoform X3

  6. XM_054353163.1 → XP_054209138.1  ran-binding protein 17 isoform X6

  7. XM_054353164.1 → XP_054209139.1  ran-binding protein 17 isoform X7

  8. XM_054353165.1 → XP_054209140.1  ran-binding protein 17 isoform X8

  9. XM_054353166.1 → XP_054209141.1  ran-binding protein 17 isoform X9

  10. XM_054353168.1 → XP_054209143.1  ran-binding protein 17 isoform X11

  11. XM_054353169.1 → XP_054209144.1  ran-binding protein 17 isoform X12

  12. XM_054353171.1 → XP_054209146.1  ran-binding protein 17 isoform X14

  13. XM_054353170.1 → XP_054209145.1  ran-binding protein 17 isoform X13

    UniProtKB/TrEMBL
    Q8IVM9

  14. XM_054353167.1 → XP_054209142.1  ran-binding protein 17 isoform X10

  15. XM_054353172.1 → XP_054209147.1  ran-binding protein 17 isoform X15

  16. XM_054353173.1 → XP_054209148.1  ran-binding protein 17 isoform X16

RNA

  1. XR_008487154.1 RNA Sequence

  2. XR_008487156.1 RNA Sequence

  3. XR_008487157.1 RNA Sequence

  4. XR_008487155.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2T7.1 GenPept UniProtKB/Swiss-Prot:Q9H2T7

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