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ARMCX5 armadillo repeat containing X-linked 5 [ Homo sapiens (human) ]

Gene ID: 64860, updated on 3-Nov-2024

Summary

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Official Symbol
ARMCX5provided by HGNC
Official Full Name
armadillo repeat containing X-linked 5provided by HGNC
Primary source
HGNC:HGNC:25772
See related
Ensembl:ENSG00000125962 MIM:301047; AllianceGenome:HGNC:25772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP5
Expression
Ubiquitous expression in thyroid (RPKM 7.2), prostate (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ARMCX5 in Genome Data Viewer
Location:
Xq22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (102599206..102604159)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (101044161..101049114)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (101854134..101859087)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene nuclear RNA export factor 5 pseudogene Neighboring gene forkhead box N3 pseudogene 1 Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene nuclear RNA export factor 4 (pseudogene) Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:101854489-101855260 Neighboring gene H3 histone pseudogene 45 Neighboring gene G protein-coupled receptor associated sorting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
  3. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. Xie L, et al. PLoS Genet, 2012. PMID 23284306, Free PMC Article
  4. ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia. Lao L, et al. Nucleic Acids Res, 2022 Jun 24. PMID 35687106, Free PMC Article
  5. Agrin has a pathological role in the progression of oral cancer. Rivera C, et al. Br J Cancer, 2018 Jun. PMID 29872149, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ARMCX5-GPRASP2

Readthrough gene: ARMCX5-GPRASP2, Included gene: GPRASP1, Included gene: GPRASP3, Included gene: GPRASP2, Included gene: LINC00630

Homology

Clone Names

  • FLJ12969, FLJ13382, DKFZp686A22185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
armadillo repeat-containing X-linked protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016347.1 RefSeqGene

    Range
    5348..9992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001168478.2 → NP_001161950.1  armadillo repeat-containing X-linked protein 5

    See identical proteins and their annotated locations for NP_001161950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AL537480, BC064983
    Consensus CDS
    CCDS14500.1
    UniProtKB/Swiss-Prot
    B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
    Related
    ENSP00000473737.2, ENST00000473968.7
    Conserved Domains (1) summary
    pfam04826
    Location:300 → 552
    Arm_2; Armadillo-like

  2. NM_001168479.2 → NP_001161951.1  armadillo repeat-containing X-linked protein 5

    See identical proteins and their annotated locations for NP_001161951.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AK096692, BC000792, BI765968
    Consensus CDS
    CCDS14500.1
    UniProtKB/Swiss-Prot
    B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
    Conserved Domains (1) summary
    pfam04826
    Location:300 → 552
    Arm_2; Armadillo-like

  3. NM_001168480.2 → NP_001161952.1  armadillo repeat-containing X-linked protein 5

    See identical proteins and their annotated locations for NP_001161952.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AK096692, BC000792
    Consensus CDS
    CCDS14500.1
    UniProtKB/Swiss-Prot
    B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
    Related
    ENSP00000246174.2, ENST00000246174.6
    Conserved Domains (1) summary
    pfam04826
    Location:300 → 552
    Arm_2; Armadillo-like

  4. NM_001168482.2 → NP_001161954.1  armadillo repeat-containing X-linked protein 5

    See identical proteins and their annotated locations for NP_001161954.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC064983, BX352705
    Consensus CDS
    CCDS14500.1
    UniProtKB/Swiss-Prot
    B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
    Related
    ENSP00000474484.2, ENST00000477663.6
    Conserved Domains (1) summary
    pfam04826
    Location:300 → 552
    Arm_2; Armadillo-like

  5. NM_001168485.2 → NP_001161957.1  armadillo repeat-containing X-linked protein 5

    See identical proteins and their annotated locations for NP_001161957.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AK096692, BC064983, DN991222
    Consensus CDS
    CCDS14500.1
    UniProtKB/Swiss-Prot
    B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
    Conserved Domains (1) summary
    pfam04826
    Location:300 → 552
    Arm_2; Armadillo-like

  6. NM_022838.4 → NP_073749.2  armadillo repeat-containing X-linked protein 5

    See identical proteins and their annotated locations for NP_073749.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC064983
    Consensus CDS
    CCDS14500.1
    UniProtKB/Swiss-Prot
    B3KU88, D3DX99, Q68DB4, Q6P1M9, Q9BVZ3, Q9H969
    Related
    ENSP00000474470.2, ENST00000479502.2
    Conserved Domains (1) summary
    pfam04826
    Location:300 → 552
    Arm_2; Armadillo-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    102599206..102604159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    101044161..101049114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1M9.1 GenPept UniProtKB/Swiss-Prot:Q6P1M9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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