Gphn gephyrin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gphnprovided by RGD
Official Full Name: gephyrinprovided by RGD
Primary source: RGD:69194
See related: EnsemblRapid:ENSRNOG00000064630 AllianceGenome:RGD:69194
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Geph
Summary: Enables several functions, including identical protein binding activity; molybdopterin adenylyltransferase activity; and molybdopterin molybdotransferase activity. Involved in establishment of protein localization; neurotransmitter receptor localization to postsynaptic specialization membrane; and synapse assembly. Acts upstream of or within Mo-molybdopterin cofactor biosynthetic process. Located in several cellular components, including GABA-ergic synapse; cytoplasmic side of plasma membrane; and inhibitory synapse. Is active in glycinergic synapse and postsynaptic specialization, intracellular component. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 169.7), Kidney (RPKM 123.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (102687405..103216679)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (96954365..97483617)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (101327874..101859169)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons.
Title: Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons.
results support the view that the strength of inhibitory synapse was controlled by gephyrin palmitoylation.
Title: Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine.
Study shows that the glycine receptors beta-loop sequences flanking the core-binding site differentially regulate the affinity of the receptor for gephyrin and its trapping at synapses.
Title: Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses.
Study shows that activity-dependent inhibitory synapse scaling is determined by gephyrin phosphorylation and subsequent regulation of GABAA receptor diffusion.
Title: Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABA(A) Receptor Diffusion.
excitotoxicity and brain ischemia downregulate full-length gephyrin with a concomitant generation of truncated products, which affect synaptic clustering of GABAAR and cell death.
Title: Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death.
endosomal pool of PI3P, generated by the class III phosphatidylinositol 3-kinase, is important for the Cb-mediated recruitment of gephyrin and GABAA receptors to developing inhibitory postsynapses and thus the formation of postsynaptic membrane specializations.
Title: Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.
the role of gephyrin and glycine receptor (GlyR) in vestibular compensation, was investigated.
Title: Expression of glycine receptors and gephyrin in rat medial vestibular nuclei and flocculi following unilateral labyrinthectomy.
these data reveal that IQSEC3 acts together with gephyrin to regulate inhibitory synapse development.
Title: IQ Motif and SEC7 Domain-containing Protein 3 (IQSEC3) Interacts with Gephyrin to Promote Inhibitory Synapse Formation.
CDK5 plays an essential role for the stability of gephyrin-dependent GABAA receptor clusters in hippocampal neurons.
Title: Cyclin-dependent kinase 5 is involved in the phosphorylation of gephyrin and clustering of GABAA receptors at inhibitory synapses of hippocampal neurons.
Results show that PKC-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.
Title: Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gphn (e-PCR), detects polymorphism
- UniSTS:536577

BE106545 (e-PCR)
- UniSTS:246309

D6Got125 (e-PCR)
- UniSTS:115790

D6Got126 (e-PCR)
- UniSTS:112726

RH136931 (e-PCR)
- UniSTS:219020

MARC_1069-1070:991929832:1 (e-PCR)
- UniSTS:230842

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables molybdopterin adenylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables molybdopterin adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin cofactor binding	ISO Inferred from Sequence Orthology more info
enables molybdopterin molybdotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin molybdotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables molybdopterin molybdotransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin molybdotransferase activity	ISO Inferred from Sequence Orthology more info
enables nitrate reductase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of synaptic specificity at neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of synaptic specificity at neuromuscular junction	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycine receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
involved_in protein targeting	TAS Traceable Author Statement more info	PubMed
involved_in response to metal ion	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glycinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization, intracellular component	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: gephyrin

Names: putative glycine receptor-tubulin linker protein

NP_074056.2

EC 2.10.1.1

EC 2.7.7.75

XP_038968825.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968827.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968828.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968830.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968832.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968833.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968834.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968836.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968837.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968838.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968839.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968840.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968841.1

EC 2.10.1.1

EC 2.7.7.75

XP_038968843.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118520.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118521.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118522.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118523.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118524.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118526.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118527.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118528.1

EC 2.10.1.1

EC 2.7.7.75

XP_063118529.1

EC 2.10.1.1

EC 2.7.7.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434119.1 → NP_001421048.1 gephyrin isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434120.1 → NP_001421049.1 gephyrin isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434121.1 → NP_001421050.1 gephyrin isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434122.1 → NP_001421051.1 gephyrin isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434123.1 → NP_001421052.1 gephyrin isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434126.1 → NP_001421055.1 gephyrin isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434127.1 → NP_001421056.1 gephyrin isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434128.1 → NP_001421057.1 gephyrin isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434129.1 → NP_001421058.1 gephyrin isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434130.1 → NP_001421059.1 gephyrin isoform 11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_001434131.1 → NP_001421060.1 gephyrin isoform 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006
NM_022865.5 → NP_074056.2 gephyrin isoform 1

See identical proteins and their annotated locations for NP_074056.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HCD7

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:327 → 733

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

102687405..103216679

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112910.2 → XP_038968838.1 gephyrin isoform X15

UniProtKB/TrEMBL

A6HCD6

Related

ENSRNOP00000098443.1, ENSRNOT00000120830.2

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:363 → 769

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112897.2 → XP_038968825.1 gephyrin isoform X1

UniProtKB/TrEMBL

A6HCD6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:430 → 836

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112902.2 → XP_038968830.1 gephyrin isoform X6

UniProtKB/TrEMBL

A6HCD6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:409 → 815

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112899.2 → XP_038968827.1 gephyrin isoform X4

UniProtKB/TrEMBL

A6HCD6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:416 → 822

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112904.2 → XP_038968832.1 gephyrin isoform X7

UniProtKB/TrEMBL

A6HCD6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:395 → 801

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112900.2 → XP_038968828.1 gephyrin isoform X5

UniProtKB/TrEMBL

A6HCD6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:411 → 817

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112905.2 → XP_038968833.1 gephyrin isoform X9

UniProtKB/TrEMBL

A6HCD6

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:390 → 796

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112908.2 → XP_038968836.1 gephyrin isoform X13

UniProtKB/TrEMBL

A6HCD6

Related

ENSRNOP00000083857.2, ENSRNOT00000101616.3

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:376 → 782

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_063262452.1 → XP_063118522.1 gephyrin isoform X8
XM_039112906.2 → XP_038968834.1 gephyrin isoform X12

UniProtKB/TrEMBL

A0A8I5ZQC9

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:380 → 786

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_063262456.1 → XP_063118526.1 gephyrin isoform X18

UniProtKB/Swiss-Prot

Q03555

Related

ENSRNOP00000098444.2, ENSRNOT00000120831.2
XM_039112913.2 → XP_038968841.1 gephyrin isoform X21

UniProtKB/TrEMBL

A6HCD7

Conserved Domains (2) summary

cd00886
Location:15 → 182

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:340 → 746

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_063262451.1 → XP_063118521.1 gephyrin isoform X3
XM_063262453.1 → XP_063118523.1 gephyrin isoform X10

Related

ENSRNOP00000082164.2, ENSRNOT00000107245.3
XM_063262459.1 → XP_063118529.1 gephyrin isoform X23
XM_063262454.1 → XP_063118524.1 gephyrin isoform X11
XM_039112911.2 → XP_038968839.1 gephyrin isoform X17

UniProtKB/TrEMBL

A0A8I6A9T9, A6HCD7

Related

ENSRNOP00000088628.1, ENSRNOT00000118026.3

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:360 → 766

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112909.2 → XP_038968837.1 gephyrin isoform X14

UniProtKB/TrEMBL

A0A8I6A568, A6HCD7

Related

ENSRNOP00000087130.1, ENSRNOT00000114358.3

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:367 → 773

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112912.2 → XP_038968840.1 gephyrin isoform X19

UniProtKB/TrEMBL

A6HCD7

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:346 → 752

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_039112915.2 → XP_038968843.1 gephyrin isoform X16

UniProtKB/TrEMBL

A6HCD7

Related

ENSRNOP00000097129.2, ENSRNOT00000104959.3

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:362 → 768

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_063262457.1 → XP_063118527.1 gephyrin isoform X20
XM_063262450.1 → XP_063118520.1 gephyrin isoform X2
XM_063262458.1 → XP_063118528.1 gephyrin isoform X22