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Csnk1g3 casein kinase 1, gamma 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64823, updated on 10-Oct-2024

Summary

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Official Symbol
Csnk1g3provided by RGD
Official Full Name
casein kinase 1, gamma 3provided by RGD
Primary source
RGD:621408
See related
EnsemblRapid:ENSRNOG00000016677 AllianceGenome:RGD:621408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G3 (casein kinase 1 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 176.2), Thymus (RPKM 175.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csnk1g3 in Genome Data Viewer
Location:
18q11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (49497839..49584828)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (47299547..47386538)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (48831209..48913341)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 120 Neighboring gene uncharacterized LOC134483022 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 2 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 12 Neighboring gene uncharacterized LOC134483023

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. Zhai L, et al. J Biol Chem, 1995 May 26. PMID 7759525
  2. Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation. Negro A, et al. FASEB J, 2002 Feb. PMID 11744621
  3. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Chia R, et al. Nat Commun, 2014 Dec 15. PMID 25500533, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase I isoform gamma-3; casein kinase I
Names
CKI-gamma 3
NP_001380678.1
NP_001380679.1
NP_074046.1
XP_063133617.1
XP_063133618.1
XP_063133619.1
XP_063133620.1
XP_063133621.1
XP_063133622.1
XP_063133623.1
XP_063133625.1
XP_063133626.1
XP_063133627.1
XP_063133628.1
XP_063133629.1
XP_063133630.1
XP_063133631.1
XP_063133632.1
XP_063133633.1
XP_063133634.1
XP_063133635.1
XP_063133636.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393749.1 → NP_001380678.1  casein kinase I isoform gamma-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0A0MXY3, A0A8I6AUP7, A6IX41
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. NM_001393750.1 → NP_001380679.1  casein kinase I isoform gamma-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A0A0MXY3, A6IX40
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 386
    CK1gamma_C; Casein kinase 1 gamma C terminal

  3. NM_022855.3 → NP_074046.1  casein kinase I isoform gamma-3 isoform 1

    See identical proteins and their annotated locations for NP_074046.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q62763
    UniProtKB/TrEMBL
    A0A0A0MXY3, A6IX39
    Related
    ENSRNOP00000093418.1, ENSRNOT00000103210.2
    Conserved Domains (2) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 418
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    49497839..49584828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277556.1 → XP_063133626.1  casein kinase I isoform X5

    Related
    ENSRNOP00000022792.6, ENSRNOT00000022792.7

  2. XM_063277547.1 → XP_063133617.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I6G3W6, A6IX38

  3. XM_063277557.1 → XP_063133627.1  casein kinase I isoform X6

  4. XM_063277553.1 → XP_063133623.1  casein kinase I isoform X3

  5. XM_063277559.1 → XP_063133629.1  casein kinase I isoform X8

  6. XM_063277563.1 → XP_063133633.1  casein kinase I isoform X11

  7. XM_063277552.1 → XP_063133622.1  casein kinase I isoform X2

  8. XM_063277558.1 → XP_063133628.1  casein kinase I isoform X7

  9. XM_063277555.1 → XP_063133625.1  casein kinase I isoform X4

  10. XM_063277562.1 → XP_063133632.1  casein kinase I isoform X10

  11. XM_063277566.1 → XP_063133636.1  casein kinase I isoform X13

  12. XM_063277549.1 → XP_063133619.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I6G3W6, A6IX38
    Related
    ENSRNOP00000079920.1, ENSRNOT00000098391.2

  13. XM_063277560.1 → XP_063133630.1  casein kinase I isoform X9

    UniProtKB/TrEMBL
    A6IX40

  14. XM_063277564.1 → XP_063133634.1  casein kinase I isoform X12

    UniProtKB/TrEMBL
    A0A8I6AUP7, A6IX41
    Related
    ENSRNOP00000097230.1, ENSRNOT00000111040.2

  15. XM_063277565.1 → XP_063133635.1  casein kinase I isoform X12

    UniProtKB/TrEMBL
    A0A8I6AUP7, A6IX41

  16. XM_063277548.1 → XP_063133618.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I6G3W6, A6IX38

  17. XM_063277561.1 → XP_063133631.1  casein kinase I isoform X9

    UniProtKB/TrEMBL
    A6IX40

  18. XM_063277550.1 → XP_063133620.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I6G3W6, A6IX38

  19. XM_063277551.1 → XP_063133621.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I6G3W6, A6IX38
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62763.1 GenPept UniProtKB/Swiss-Prot:Q62763

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