U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 6482, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ST3GAL1provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:10862
See related
Ensembl:ENSG00000008513 MIM:607187; AllianceGenome:HGNC:10862
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8q24.22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (133454848..133571887, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (134578690..134699857, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134467091..134584130, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134420089-134420640 Neighboring gene DPPA3 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134434961-134435460 Neighboring gene ST13, Hsp70 interacting protein pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134461533-134461691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134465210-134465710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134465711-134466211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27996 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134500724-134501507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134502985-134503530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134512049-134512574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:134513872-134514372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28003 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:134544558-134545408 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:134581917-134582770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19566 Neighboring gene ST3GAL1 divergent transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101278 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:134643666-134643864 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene long intergenic non-protein coding RNA 3024

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer. Lin WD, et al. Cancer Immunol Res, 2021 Jan. PMID 33177111
  2. Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1). Ortiz-Soto ME, et al. Sci Rep, 2019 Nov 29. PMID 31784620, Free PMC Article
  3. α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells. Wen KC, et al. Oncotarget, 2017 Apr 25. PMID 28423672, Free PMC Article
  4. ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis. Chong YK, et al. J Natl Cancer Inst, 2016 Feb. PMID 26547933, Free PMC Article
  5. Siaα2-3Galβ1- Receptor Genetic Variants Are Associated with Influenza A(H1N1)pdm09 Severity. Maestri A, et al. PLoS One, 2015. PMID 26436774, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
    Title: Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation.
  2. Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
    Title: Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer.
  3. ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
    Title: ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL.
  4. Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).
    Title: Structural and functional role of disulphide bonds and substrate binding residues of the human beta-galactoside alpha-2,3-sialyltransferase 1 (hST3Gal1).
  5. ST3GAL1 promotes cell migration, invasion, and TGFB1-induced epithelial-mesenchymal transition and confers paclitaxel resistance in ovarian cancer.
    Title: Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-β1-induced EMT and confers paclitaxel resistance in ovarian cancer.
  6. Data suggest that GDNF family receptor alpha 1 protein (GFRA1) is a protein target of ST3 beta-galactoside alpha-23-sialyltransferase 1 (ST3GAL1).
    Title: Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells.
  7. Expression levels of ST3Gal1 and TGFB1 were high in breast cancer tumors samples and positively correlated with each other. Shorter relapse-free survival associated with lower expression of VASN and combination of low VASN with high ST3GAL1 yielded even higher risk of recurrence. Findings illustrated a feedback regulatory loop in which TGF-beta1 upregulates ST3Gal1 to circumvent the negative impact of VASN.
    Title: Sialylation of vasorin by ST3Gal1 facilitates TGF-β1-mediated tumor angiogenesis and progression.
  8. Study demonstrates that ST3GalI regulates ovarian cancer cell migration and peritoneal dissemination via EGFR signaling.
    Title: α2,3-sialyltransferase type I regulates migration and peritoneal dissemination of ovarian cancer cells.
  9. ST3Gal I and ST6Gal I have different sialic acid donor specificity.
    Title: Probing the CMP-Sialic Acid Donor Specificity of Two Human β-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins.
  10. Describe differential expression profiles of alpha-2, 3-sialyltransferases (ST) and miR-4701-5p in three pairs of chronic myeloid leukemia (CML) cell lines and 48 clinical samples of bone marrow mononuclear cells from CML patients. miR-4701-5p directly targeted ST3GAL1 to reduce CML cells resistance to multiple chemotherapeutics in vitro.
    Title: Alpha-2, 3-sialyltransferases regulate the multidrug resistance of chronic myeloid leukemia through miR-4701-5p targeting ST3GAL1.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
EBI GWAS Catalog
Genome-wide association study and meta-analysis of intraocular pressure.
EBI GWAS Catalog
Genome-wide association study of the five-factor model of personality in young Korean women.
EBI GWAS Catalog
Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC9183, FLJ36548, DKFZp666E036, DKFZp779K2051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
Traceable Author Statement
more info
  
enables sialyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in N-acetylneuraminate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in O-glycan processing TAS
Traceable Author Statement
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in memory B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein sialylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in viral protein processing TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in Golgi medial cisterna membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in Golgi trans cisterna membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Names
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
SIAT4-A
ST3GalI
alpha 2,3-ST 1
beta-galactoside alpha-2,3-sialyltransferase 1
monosialoganglioside sialyltransferase
sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
NP_003024.1
NP_775479.1
XP_005251082.1
XP_006716680.1
XP_016869225.1
XP_047278061.1
XP_047278062.1
XP_054216992.1
XP_054216993.1
XP_054216994.1
XP_054216995.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003033.4 → NP_003024.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    See identical proteins and their annotated locations for NP_003024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF186191, BC018357, BX648001
    Consensus CDS
    CCDS6373.1
    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51
    Related
    ENSP00000428540.1, ENST00000521180.5
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_173344.3 → NP_775479.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    See identical proteins and their annotated locations for NP_775479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF059321, AF186191, BC018357, BX648001, CN359425
    Consensus CDS
    CCDS6373.1
    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51
    Related
    ENSP00000430515.1, ENST00000522652.6
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    133454848..133571887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013736.3 → XP_016869225.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006716617.3 → XP_006716680.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006716680.1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51
    Related
    ENSP00000497381.1, ENST00000648219.1
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_047422106.1 → XP_047278062.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51

  4. XM_047422105.1 → XP_047278061.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51

  5. XM_005251025.6 → XP_005251082.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005251082.1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51
    Conserved Domains (1) summary
    pfam00777
    Location:83 → 338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    134578690..134699857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361018.1 → XP_054216993.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51

  2. XM_054361017.1 → XP_054216992.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51

  3. XM_054361020.1 → XP_054216995.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51

  4. XM_054361019.1 → XP_054216994.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O60677, Q11201, Q9UN51
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q11201.1 GenPept UniProtKB/Swiss-Prot:Q11201

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous