U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF574 zinc finger protein 574 [ Homo sapiens (human) ]

Gene ID: 64763, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF574provided by HGNC
Official Full Name
zinc finger protein 574provided by HGNC
Primary source
HGNC:HGNC:26166
See related
Ensembl:ENSG00000105732 AllianceGenome:HGNC:26166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP972
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 9.8), ovary (RPKM 4.8) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
19q13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42068477..42081552)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44887841..44900921)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42572629..42585704)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10679 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14695 Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10682 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:42536134-42536906 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:42539441-42539940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10684 Neighboring gene POU class 2 homeobox 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14702 Neighboring gene Sharpr-MPRA regulatory region 1615 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42653684-42654184 Neighboring gene microRNA 4323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42654185-42654685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42659146-42659674 Neighboring gene long non-coding regulator of POU2F2 Neighboring gene POU2F2 antisense RNA 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways. Zhang J, et al. Ann Clin Lab Sci, 2022 Jul. PMID 36197766
  2. A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C. Cano F, et al. Nat Commun, 2015 Oct 16. PMID 26471122, Free PMC Article
  3. Multidimensional Proteomics Reveals a Role of UHRF2 in the Regulation of Epithelial-Mesenchymal Transition (EMT). Lai M, et al. Mol Cell Proteomics, 2016 Jul. PMID 27114453, Free PMC Article
  4. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  5. Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase. Neveu G, et al. Methods, 2012 Dec. PMID 22898364, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways.
    Title: ZNF574 Promotes Ovarian Cancer Cell Proliferation and Migration through Regulating AKT and AMPK Signaling Pathways.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ22059

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 574

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330519.2 → NP_001317448.1  zinc finger protein 574 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF447880, AK131369
    Consensus CDS
    CCDS82356.1
    UniProtKB/TrEMBL
    A0A0C4DFM2
    Related
    ENSP00000222339.6, ENST00000222339.7

  2. NM_022752.6 → NP_073589.4  zinc finger protein 574 isoform 1

    See identical proteins and their annotated locations for NP_073589.4

    Status: VALIDATED

    Source sequence(s)
    AF447880, BC001184, DA404303
    Consensus CDS
    CCDS12596.1
    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
    Related
    ENSP00000351939.3, ENST00000359044.5
    Conserved Domains (4) summary
    cd11674
    Location:437 → 491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495 → 848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311 → 390
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    42068477..42081552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527228.4 → XP_011525530.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_011525530.1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
    Conserved Domains (4) summary
    cd11674
    Location:437 → 491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495 → 848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311 → 390
    zf-C2H2_8; C2H2-type zinc ribbon

  2. XM_011527230.4 → XP_011525532.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_011525532.1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
    Related
    ENSP00000469029.1, ENST00000600245.1
    Conserved Domains (4) summary
    cd11674
    Location:437 → 491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495 → 848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311 → 390
    zf-C2H2_8; C2H2-type zinc ribbon

  3. XM_011527229.4 → XP_011525531.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_011525531.1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
    Conserved Domains (4) summary
    cd11674
    Location:437 → 491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495 → 848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311 → 390
    zf-C2H2_8; C2H2-type zinc ribbon

  4. XM_005259159.4 → XP_005259216.1  zinc finger protein 574 isoform X1

    See identical proteins and their annotated locations for XP_005259216.1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
    Conserved Domains (4) summary
    cd11674
    Location:437 → 491
    lambda-1; inner capsid protein lambda-1 or VP3
    COG5048
    Location:495 → 848
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:497 → 517
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:311 → 390
    zf-C2H2_8; C2H2-type zinc ribbon

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44887841..44900921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321781.1 → XP_054177756.1  zinc finger protein 574 isoform X1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0

  2. XM_054321783.1 → XP_054177758.1  zinc finger protein 574 isoform X1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0

  3. XM_054321782.1 → XP_054177757.1  zinc finger protein 574 isoform X1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0

  4. XM_054321780.1 → XP_054177755.1  zinc finger protein 574 isoform X1

    UniProtKB/Swiss-Prot
    Q6IPE0, Q6ZN10, Q6ZN55, Q7L5Z5, Q8NCE3, Q9H6N0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN55.2 GenPept UniProtKB/Swiss-Prot:Q6ZN55

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous