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FHIP2B FHF complex subunit HOOK interacting protein 2B [ Homo sapiens (human) ]

Gene ID: 64760, updated on 5-Mar-2024

Summary

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Official Symbol
FHIP2Bprovided by HGNC
Official Full Name
FHF complex subunit HOOK interacting protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:16492
See related
Ensembl:ENSG00000158863 MIM:620230; AllianceGenome:HGNC:16492
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAI16; RAI16; FAM160B2; RAM160B2
Expression
Ubiquitous expression in skin (RPKM 11.2), prostate (RPKM 9.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See FHIP2B in Genome Data Viewer
Location:
8p21.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (22089150..22104911)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (22363108..22378867)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21946661..21962422)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903342-21903848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21903849-21904354 Neighboring gene fibroblast growth factor 17 Neighboring gene VISTA enhancer hs781 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21908959-21909751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21915443-21916404 Neighboring gene dematin actin binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21917368-21918329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18975 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:21943692-21944301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21951526-21952026 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21961808-21961955 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 8:21964802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21965271-21966044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21969459-21969958 Neighboring gene nudix hydrolase 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21972531-21973193 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:21977874-21978076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21978415-21978914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21981891-21982392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21982393-21982892 Neighboring gene HR lysine demethylase and nuclear receptor corepressor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:21987125-21987702 Neighboring gene HR upstream open reading frame

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70. Ding CL, et al. Oncotarget, 2015 Jun 20. PMID 25900241, Free PMC Article
  2. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma. Wang W, et al. Carcinogenesis, 2012 Dec. PMID 22971576
  3. Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells. Ding CL, et al. Mol Cell Endocrinol, 2020 Apr 15. PMID 32014455
  4. Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice. Xu YL, et al. Cell Death Dis, 2019 Dec 20. PMID 31862898, Free PMC Article
  5. FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems. Mavioğlu RN, et al. Clin Genet, 2019 Nov. PMID 31353455

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells.
    Title: Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells.
  2. Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.
    Title: Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.
  3. FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems.
    Title: FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems.
  4. RAI16 interacted with the type II regulatory subunit of protein kinase A(PKA-RIIalpha), acting as a novel protein kinase A anchoring protein (AKAP). In addition, RAI16 also interacted with heat shock protein 70 (HSP70) and 14-3-3theta;.
    Title: Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70.
  5. Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma.
    Title: Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11125, FLJ21801, MGC138352

General protein information

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Preferred Names
FHF complex subunit HOOK-interacting protein 2B
Names
family with sequence similarity 160 member B2
protein FAM160B2
retinoic acid induced 16
retinoic acid-induced protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354250.2 → NP_001341179.1  FHF complex subunit HOOK-interacting protein 2B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC091171
    Conserved Domains (1) summary
    pfam10257
    Location:79 → 475
    RAI16-like; Retinoic acid induced 16-like protein

  2. NM_001354251.2 → NP_001341180.1  FHF complex subunit HOOK-interacting protein 2B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC091171
    Conserved Domains (1) summary
    pfam10257
    Location:21 → 418
    RAI16-like; Retinoic acid induced 16-like protein

  3. NM_022749.7 → NP_073586.5  FHF complex subunit HOOK-interacting protein 2B isoform 1

    See identical proteins and their annotated locations for NP_073586.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC091171
    Consensus CDS
    CCDS6021.2
    UniProtKB/Swiss-Prot
    B2RDQ5, B3KNX1, Q2M211, Q71JB5, Q7L3J6, Q86V87, Q969T0, Q9H6W4
    Related
    ENSP00000289921.6, ENST00000289921.8
    Conserved Domains (1) summary
    pfam10257
    Location:79 → 476
    RAI16-like; Retinoic acid induced 16-like protein

RNA

  1. NR_148727.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091171, BC052237, HY033313

  2. NR_148728.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091171

  3. NR_148729.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091171

  4. NR_148730.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091171

  5. NR_148731.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC091171

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    22089150..22104911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716381.4 → XP_006716444.1  FHF complex subunit HOOK-interacting protein 2B isoform X1

    Conserved Domains (1) summary
    pfam10257
    Location:79 → 476
    RAI16-like; Retinoic acid induced 16-like protein

  2. XM_005273602.5 → XP_005273659.1  FHF complex subunit HOOK-interacting protein 2B isoform X2

    See identical proteins and their annotated locations for XP_005273659.1

    Conserved Domains (1) summary
    pfam10257
    Location:79 → 476
    RAI16-like; Retinoic acid induced 16-like protein

RNA

  1. XR_007060751.1 RNA Sequence

  2. XR_428314.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    22363108..22378867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361015.1 → XP_054216990.1  FHF complex subunit HOOK-interacting protein 2B isoform X1

  2. XM_054361016.1 → XP_054216991.1  FHF complex subunit HOOK-interacting protein 2B isoform X2

RNA

  1. XR_008487870.1 RNA Sequence

  2. XR_008487871.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86V87.2 GenPept UniProtKB/Swiss-Prot:Q86V87

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