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UNKL unk like zinc finger [ Homo sapiens (human) ]

Gene ID: 64718, updated on 3-Apr-2024

Summary

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Official Symbol
UNKLprovided by HGNC
Official Full Name
unk like zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:14184
See related
Ensembl:ENSG00000059145 MIM:617463; AllianceGenome:HGNC:14184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZC3H5L; C16orf28; ZC3HDC5L
Summary
This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in ovary (RPKM 4.2), endometrium (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1363205..1414704, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1379337..1429329, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1413206..1464705, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10221 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1382600-1382800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6970 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1388370-1389219 Neighboring gene BAI1 associated protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1392110-1392658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6972 Neighboring gene TSR3 ribosome maturation factor Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1425173-1425672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6974 Neighboring gene tight junction protein 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6976 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1458173-1458350 Neighboring gene uncharacterized LOC101929440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1463606-1464180 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1464181-1464755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1464756-1465330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1465331-1465904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1470039-1470894 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1470895-1471748 Neighboring gene uncharacterized LOC105371044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6984 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. Lorès P, et al. FEBS J, 2010 Mar. PMID 20148946
  2. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Mohler J, et al. Genetics, 1992 Jun. PMID 1339381, Free PMC Article
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Daniels RJ, et al. Hum Mol Genet, 2001 Feb 15. PMID 11157797
  4. The sequence and analysis of duplication-rich human chromosome 16. Martin J, et al. Nature, 2004 Dec 23. PMID 15616553
  5. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterizes the related Drosophila gene and protein.
    Title: The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5179, FLJ12623, FLJ23360, KIAA0734

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative E3 ubiquitin-protein ligase UNKL
Names
RING finger protein unkempt-like
unkempt family zinc finger-like
unkempt homolog-like
zinc finger CCCH domain-containing protein 5-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033129.1 RefSeqGene

    Range
    5001..56500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001037125.4 → NP_001032202.1  putative E3 ubiquitin-protein ligase UNKL isoform 2

    See identical proteins and their annotated locations for NP_001032202.1

    Status: REVIEWED

    Source sequence(s)
    AL031721, AL032819
    Consensus CDS
    CCDS32359.1
    UniProtKB/Swiss-Prot
    Q9H9P5
    Related
    ENSP00000301712.5, ENST00000301712.5
    Conserved Domains (1) summary
    pfam18384
    Location:25 → 60
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

  2. NM_001193388.4 → NP_001180317.2  putative E3 ubiquitin-protein ligase UNKL isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721, AL032819
    UniProtKB/Swiss-Prot
    B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
    UniProtKB/TrEMBL
    E9PDK2
    Related
    ENSP00000422852.3, ENST00000508903.7
    Conserved Domains (4) summary
    pfam18384
    Location:25 → 60
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
    pfam00642
    Location:286 → 312
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13868
    Location:569 → 649
    TPH; Trichohyalin-plectin-homology domain
    cl17238
    Location:640 → 683
    RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

  3. NM_001193389.2 → NP_001180318.1  putative E3 ubiquitin-protein ligase UNKL isoform 4

    See identical proteins and their annotated locations for NP_001180318.1

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Consensus CDS
    CCDS53980.1
    UniProtKB/Swiss-Prot
    Q9H9P5
    Related
    ENSP00000501444.1, ENST00000674376.1
    Conserved Domains (1) summary
    pfam13920
    Location:139 → 176
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  4. NM_001276414.2 → NP_001263343.1  putative E3 ubiquitin-protein ligase UNKL isoform 5

    See identical proteins and their annotated locations for NP_001263343.1

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Consensus CDS
    CCDS61787.1
    UniProtKB/Swiss-Prot
    Q9H9P5
    Related
    ENSP00000248104.7, ENST00000248104.11
    Conserved Domains (1) summary
    pfam13920
    Location:186 → 223
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  5. NM_001367622.1 → NP_001354551.1  putative E3 ubiquitin-protein ligase UNKL isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721

  6. NM_001370526.1 → NP_001357455.1  putative E3 ubiquitin-protein ligase UNKL isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Conserved Domains (1) summary
    pfam03962
    Location:75 → 143
    Mnd1; Mnd1 family

  7. NM_001372107.1 → NP_001359036.1  putative E3 ubiquitin-protein ligase UNKL isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721, AL032819
    Consensus CDS
    CCDS92080.1
    UniProtKB/Swiss-Prot
    B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
    UniProtKB/TrEMBL
    A0A0A0MRZ1
    Related
    ENSP00000373873.6, ENST00000389221.9
    Conserved Domains (5) summary
    pfam04012
    Location:569 → 699
    PspA_IM30; PspA/IM30 family
    cd16772
    Location:690 → 727
    RING-HC_UNKL; RING finger, HC subclass, found in RING finger protein unkempt-like (UNKL) and similar proteins
    pfam00642
    Location:286 → 311
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam02161
    Location:442 → 534
    Prog_receptor; Progesterone receptor
    pfam18384
    Location:25 → 60
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

RNA

  1. NR_160278.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721, AL032819

  2. NR_160279.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721

  3. NR_160280.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721

  4. NR_163466.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031709, AL031721
    Related
    ENST00000403703.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    1363205..1414704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434489.1 → XP_047290445.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

  2. XM_047434488.1 → XP_047290444.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

  3. XM_011522612.2 → XP_011520914.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

    UniProtKB/Swiss-Prot
    B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
    Conserved Domains (3) summary
    pfam00642
    Location:236 → 262
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam13863
    Location:519 → 593
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:640 → 677
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  4. XM_047434491.1 → XP_047290447.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

  5. XM_011522611.2 → XP_011520913.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

    UniProtKB/Swiss-Prot
    B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
    Conserved Domains (3) summary
    pfam00642
    Location:306 → 332
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam11825
    Location:482 → 553
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
    pfam13920
    Location:660 → 697
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  6. XM_011522610.2 → XP_011520912.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

    UniProtKB/Swiss-Prot
    B0QYN6, B1GXI8, Q96EV1, Q96RZ1, Q9BWL5, Q9H5K0, Q9H9P5, Q9UJJ8
    Conserved Domains (4) summary
    pfam00642
    Location:306 → 332
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam11825
    Location:482 → 553
    Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
    pfam13863
    Location:589 → 663
    DUF4200; Domain of unknown function (DUF4200)
    pfam13920
    Location:710 → 747
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  7. XM_047434490.1 → XP_047290446.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

  8. XM_047434495.1 → XP_047290451.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

  9. XM_047434493.1 → XP_047290449.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

  10. XM_047434494.1 → XP_047290450.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

  11. XM_047434492.1 → XP_047290448.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

  12. XM_017023569.2 → XP_016879058.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

    UniProtKB/Swiss-Prot
    Q9H9P5
    Conserved Domains (1) summary
    pfam13920
    Location:189 → 226
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  13. XM_011522613.2 → XP_011520915.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

    Conserved Domains (1) summary
    pfam00642
    Location:306 → 332
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RNA

  1. XR_007064900.1 RNA Sequence

  2. XR_007064899.1 RNA Sequence

  3. XR_007064898.1 RNA Sequence

  4. XR_007064897.1 RNA Sequence

  5. XR_007064896.1 RNA Sequence

  6. XR_932901.2 RNA Sequence

  7. XR_007064901.1 RNA Sequence

  8. XR_007064903.1 RNA Sequence

  9. XR_007064902.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    1379337..1429329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313698.1 → XP_054169673.1  putative E3 ubiquitin-protein ligase UNKL isoform X5

  2. XM_054313697.1 → XP_054169672.1  putative E3 ubiquitin-protein ligase UNKL isoform X4

  3. XM_054313696.1 → XP_054169671.1  putative E3 ubiquitin-protein ligase UNKL isoform X3

  4. XM_054313702.1 → XP_054169677.1  putative E3 ubiquitin-protein ligase UNKL isoform X11

  5. XM_054313701.1 → XP_054169676.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

  6. XM_054313699.1 → XP_054169674.1  putative E3 ubiquitin-protein ligase UNKL isoform X10

  7. XM_054313695.1 → XP_054169670.1  putative E3 ubiquitin-protein ligase UNKL isoform X2

  8. XM_054313694.1 → XP_054169669.1  putative E3 ubiquitin-protein ligase UNKL isoform X1

  9. XM_054313700.1 → XP_054169675.1  putative E3 ubiquitin-protein ligase UNKL isoform X6

  10. XM_054313707.1 → XP_054169682.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

  11. XM_054313706.1 → XP_054169681.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

  12. XM_054313708.1 → XP_054169683.1  putative E3 ubiquitin-protein ligase UNKL isoform X9

  13. XM_054313705.1 → XP_054169680.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

  14. XM_054313704.1 → XP_054169679.1  putative E3 ubiquitin-protein ligase UNKL isoform X8

  15. XM_054313703.1 → XP_054169678.1  putative E3 ubiquitin-protein ligase UNKL isoform X7

RNA

  1. XR_008484720.1 RNA Sequence

  2. XR_008484719.1 RNA Sequence

  3. XR_008484718.1 RNA Sequence

  4. XR_008484723.1 RNA Sequence

  5. XR_008484721.1 RNA Sequence

  6. XR_008484717.1 RNA Sequence

  7. XR_008484716.1 RNA Sequence

  8. XR_008484715.1 RNA Sequence

  9. XR_008484722.1 RNA Sequence

  10. XR_008484725.1 RNA Sequence

  11. XR_008484724.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024023.1: Suppressed sequence

    Description
    NM_024023.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H9P5.3 GenPept UniProtKB/Swiss-Prot:Q9H9P5

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