Srd5a2 steroid 5 alpha-reductase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srd5a2provided by RGD
Official Full Name: steroid 5 alpha-reductase 2provided by RGD
Primary source: RGD:621480
See related: EnsemblRapid:ENSRNOG00000027042 AllianceGenome:RGD:621480
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S5AR 2
Summary: Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including androgen biosynthetic process; animal organ development; and phthalate metabolic process. Located in cell body fiber; cytoplasm; and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 1.5), Testes (RPKM 1.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (27178089..27217588)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (21426225..21465727)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (25279635..25315501, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, DEHP-disturbed HPT axis and induced 5alpha-Reductase 2 contribute to the reduction of serum testosterone level. The activated ERK pathway is required to modulate expressions of 5alpha-Reductase 2 and SRB1.
Title: Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5α-Reductase 2.
Results suggest that in the acute phase after spinal cord injury, the increased expression of 18kDa translocator protein and 5alpha-reductase may represent a protective endogenous response against tissue injury.
Title: Temporal changes in the expression of the translocator protein TSPO and the steroidogenic enzyme 5α-reductase in the dorsal spinal cord of animals with neuropathic pain: Effects of progesterone administration.
findings show that, in the adult brain, 5alphaR2 is distributed in critical regions for behavioral regulation, suggesting that the functional role of this isoform is present throughout the entire lifespan of the individual
Title: Regional distribution of 5α-reductase type 2 in the adult rat brain: an immunohistochemical analysis.
Low Srd5a2 expression is associated with benign prostatic hypertrophy.
Title: Bisphenol A exposure during adulthood alters expression of aromatase and 5α-reductase isozymes in rat prostate.
Changes in the expression of steroid 5-alpha reductase isoenzymes in the prostate in response to environmental stress.
Title: Expression of steroid 5α-reductase isozymes in prostate of adult rats after environmental stress.
Tesosterone concentrations during postnatal sexual differentiation of the rat central nervous system, among other sex-dependent factors, influence brain levels of 5alpha-Reductase isozymes in adulthood
Title: Steroid 5α-reductase in adult rat brain after neonatal testosterone administration.
The SRD5A2 mRNA expression in normal rat is 4-fold higher than human prostatic tissue.
Title: Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers.
5 alpha-R2 labeling was observed in dorsal (DH) and ventral horns of gray matter (Gm). and 60% of 5 alpha-R2 immunostaining colocalized with oligodendrocyte, 25% with neuron, and 15% with astrocyte markers.
Title: Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord.
A method for the quantitation of mRNA levels of Srd5a2 isoenzymes has been developed.
Title: Quantitation of mRNA levels of steroid 5alpha-reductase isozymes: a novel method that combines quantitative RT-PCR and capillary electrophoresis.
5-alpha-reductase type 2 is confined to motoneuronal cells of anterior horns of rat spinal cord, cells that also are known to express high levels of androgen receptor.
Title: Androgen 5-alpha-reductase type 2 is highly expressed and active in rat spinal cord motor neurones.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables amide binding	IPI Inferred from Physical Interaction more info	PubMed
enables testosterone dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in androgen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biphenyl metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in bone development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in dibenzo-p-dioxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in female genitalia development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male genitalia development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
involved_in male genitalia development	TAS Traceable Author Statement more info	PubMed
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in phthalate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to biphenyl	IDA Inferred from Direct Assay more info	PubMed
involved_in response to follicle-stimulating hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sex differentiation	TAS Traceable Author Statement more info	PubMed
involved_in steroid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in steroid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in testosterone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Names: 5 alpha-SR2; SR type 2; steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

NP_073202.1

EC 1.3.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.