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Nisch nischarin [ Mus musculus (house mouse) ]

Gene ID: 64652, updated on 14-Nov-2024

Summary

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Official Symbol
Nischprovided by MGI
Official Full Name
nischarinprovided by MGI
Primary source
MGI:MGI:1928323
See related
Ensembl:ENSMUSG00000021910 AllianceGenome:MGI:1928323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
I-1; edsn; 1200007D05Rik; 3202002H23Rik
Summary
Enables integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 82.3), adrenal adult (RPKM 79.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nisch in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30892885..30928783, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31170928..31206826, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148 Neighboring gene troponin C, cardiac/slow skeletal Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. Alahari SK, et al. EMBO J, 2004 Jul 21. PMID 15229651, Free PMC Article
  2. Nischarin as a functional imidazoline (I1) receptor. Zhang J, et al. FEBS Lett, 2006 May 29. PMID 16678176
  3. Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. Tanabe M, et al. Eur J Pharmacol, 2008 Jul 28. PMID 18602099
  4. IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. Li S, et al. Biomed Pharmacother, 2022 Sep. PMID 36076473
  5. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Lui TN, et al. Neurosci Lett, 2010 May 3. PMID 20298750

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Contribution of Nischarin/IRAS in CNS development, injury and diseases.
    Title: Contribution of Nischarin/IRAS in CNS development, injury and diseases.
  2. Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
    Title: Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
  3. Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Delta5-6) Knockout Mouse Model.
    Title: Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Δ5-6) Knockout Mouse Model.
  4. Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats.
    Title: Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats.
  5. These data suggest that IRAS/Nischarin may play an important role in the development of morphine tolerance and physical dependence in vivo through modulating MOR expression, as well as AMPA GluR1-S845 phosphorylation, which might be one of the mechanisms underlying the development of opiate addiction.
    Title: The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence.
  6. results indicate that Nisch is an important AMPK inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism.
    Title: Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.
  7. We identified a significant genetic interaction between Nisch and Itga5; mice heterozygous for Itga5-null and homozygous for edison mutations display a significantly increased penetrance and severity of chronic otitis media.
    Title: A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
  8. Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons.
    Title: Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
  9. Data from studies using various receptor antagonists/agonists suggest that imidazoline receptors (Nisch I-1), alpha2-adrenoceptors, and endothelin-A receptors are involved in body temperature regulation in mice.
    Title: Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
  10. Activation of I1-imidazoline receptor ameliorated energy intake and epididymal white adipose tissue accumulation.
    Title: Improvement of obesity by activation of I1-imidazoline receptors in high fat diet-fed mice.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Rac protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nischarin
Names
I1R
IR1
imidazoline receptor 1
imidazoline receptor I-1-like protein
imidazoline-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347583.1 → NP_001334512.1  nischarin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154446, AK004628, AK160990, BY602009, CJ106892
    Consensus CDS
    CCDS84107.1
    UniProtKB/TrEMBL
    Q8CF63
    Related
    ENSMUSP00000132413.2, ENSMUST00000172142.8

  2. NM_022656.2 → NP_073147.2  nischarin isoform 1

    See identical proteins and their annotated locations for NP_073147.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154446, AK122412, BC089329, BP761152, CJ106892
    Consensus CDS
    CCDS36853.1
    UniProtKB/Swiss-Prot
    Q2YDV7, Q80TM9, Q8C354, Q8C4X9, Q8CBH0, Q91XW6, Q99LG6, Q9EPW8, Q9WUM6
    UniProtKB/TrEMBL
    B7ZN33
    Related
    ENSMUSP00000022469.7, ENSMUST00000022469.13
    Conserved Domains (5) summary
    cd06875
    Location:15 → 130
    PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
    cd00116
    Location:271 → 417
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:291 → 313
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:312 → 352
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:291 → 346
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30892885..30928783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158779.1 → XP_036014672.1  nischarin isoform X1

  2. XM_017316116.1 → XP_017171605.1  nischarin isoform X1

  3. XM_017316115.3 → XP_017171604.1  nischarin isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TM9.2 GenPept UniProtKB/Swiss-Prot:Q80TM9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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