atp1a3a ATPase Na+/K+ transporting subunit alpha 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp1a3aprovided by ZNC
Official Full Name: ATPase Na+/K+ transporting subunit alpha 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001212-7
See related: Ensembl:ENSDARG00000018259 AllianceGenome:ZFIN:ZDB-GENE-001212-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb705; atp[a]3B; wu:fj56a06
Summary: Predicted to enable P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within locomotory behavior and ventricular system development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system; neural tube; pancreas primordium; pronephric duct; and trigeminal placode. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; developmental and epileptic encephalopathy 99; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 19

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (6328245..6385541, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (6409214..6466510, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha3Na(+)/K(+)-ATPase has a role in zebrafish motility and brain development, and its deficiency has a role in brain ventricle dilation
Title: α3Na+/K+-ATPase deficiency causes brain ventricle dilation and abrupt embryonic motility in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: sodium/potassium-transporting ATPase subunit alpha-3a

Names: ATPase, Na+/K+ transporting, alpha 3a polypeptide

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131684.2 → NP_571759.2 sodium/potassium-transporting ATPase subunit alpha-3a

See identical proteins and their annotated locations for NP_571759.2

Status: PROVISIONAL

Source sequence(s)

BC064703

UniProtKB/TrEMBL

F6NKR9, Q1LUA0, Q6P271

Related

ENSDARP00000095720.3, ENSDART00000104950.4

Conserved Domains (6) summary

smart00831
Location:41 → 114

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

COG4087
Location:606 → 752

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01106
Location:30 → 1023

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

pfam00122
Location:134 → 365

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:799 → 1008

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:427 → 521

Cation_ATPase; Cation transport ATPase (P-type)