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Ptprv protein tyrosine phosphatase, receptor type, V [ Rattus norvegicus (Norway rat) ]

Gene ID: 64576, updated on 2-Nov-2024

Summary

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Official Symbol
Ptprvprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Vprovided by RGD
Primary source
RGD:621123
See related
EnsemblRapid:ENSRNOG00000005277 AllianceGenome:RGD:621123
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Esp
Summary
Enables protein tyrosine phosphatase activity. Involved in several processes, including cellular response to cAMP; cellular response to epidermal growth factor stimulus; and cellular response to parathyroid hormone stimulus. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 77.4), Uterus (RPKM 24.6) and 3 other tissues See more
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Genomic context

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See Ptprv in Genome Data Viewer
Location:
13q13
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49099922..49120247, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46548125..46569148, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51935239..51956262, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene uncharacterized LOC120096252 Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene ADP-ribosylation factor like GTPase 8A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat osteotesticular phosphatase gene (Esp): genomic structure and chromosome location. Lathrop W, et al. Mamm Genome, 1999 Apr. PMID 10087294
  2. Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation. Mauro LJ, et al. J Biol Chem, 1994 Dec 2. PMID 7527035
  3. Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells. Mauro LJ, et al. Endocrinology, 1996 Mar. PMID 8603605
  4. Congenic mapping and sequence analysis of the Renin locus. Flister MJ, et al. Hypertension, 2013 Apr. PMID 23460292, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in bone remodeling IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to cAMP IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to parathyroid hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in osteoclast development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase V
Names
ES cell phosphatase
OST-PTP
Osteotesticular phosphatase
R-PTP-V
embryonic stem cell protein-tyrosine phosphatase
osteotesticular protein-tyrosine phosphatase
protein tyrosine phosphatase receptor type W
NP_149090.1
XP_038946996.1
XP_038946997.1
XP_038946998.1
XP_038946999.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033099.1 → NP_149090.1  receptor-type tyrosine-protein phosphatase V precursor

    See identical proteins and their annotated locations for NP_149090.1

    Status: PROVISIONAL

    Source sequence(s)
    L36884
    UniProtKB/Swiss-Prot
    Q64612
    UniProtKB/TrEMBL
    A0A8I6AM78
    Related
    ENSRNOP00000007597.3, ENSRNOT00000007597.7
    Conserved Domains (6) summary
    smart00060
    Location:473 → 547
    FN3; Fibronectin type 3 domain
    smart00194
    Location:1150 → 1408
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1177 → 1408
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:656 → 725
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:131 → 201
    fn3; Fibronectin type III domain
    cl21483
    Location:1521 → 1693
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49099922..49120247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091070.2 → XP_038946998.1  receptor-type tyrosine-protein phosphatase V isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM78
    Conserved Domains (6) summary
    smart00060
    Location:473 → 547
    FN3; Fibronectin type 3 domain
    cd00063
    Location:656 → 725
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14618
    Location:1120 → 1349
    R-PTPc-V; catalytic domain of receptor-type tyrosine-protein phosphatase V
    pfam00041
    Location:148 → 201
    fn3; Fibronectin type III domain
    pfam18861
    Location:950 → 1044
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl28904
    Location:1419 → 1635
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_039091068.2 → XP_038946996.1  receptor-type tyrosine-protein phosphatase V isoform X1

    UniProtKB/TrEMBL
    A0A8I6AM78, F1M8J3
    Related
    ENSRNOP00000095225.1, ENSRNOT00000110943.2
    Conserved Domains (6) summary
    smart00060
    Location:473 → 547
    FN3; Fibronectin type 3 domain
    cd00063
    Location:656 → 725
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14618
    Location:1178 → 1407
    R-PTPc-V; catalytic domain of receptor-type tyrosine-protein phosphatase V
    pfam00041
    Location:148 → 201
    fn3; Fibronectin type III domain
    pfam18861
    Location:950 → 1102
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl28904
    Location:1477 → 1693
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_039091069.2 → XP_038946997.1  receptor-type tyrosine-protein phosphatase V isoform X2

    UniProtKB/TrEMBL
    A0A8I6AM78
    Conserved Domains (5) summary
    smart00060
    Location:432 → 506
    FN3; Fibronectin type 3 domain
    cd00063
    Location:615 → 684
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:107 → 160
    fn3; Fibronectin type III domain
    pfam18861
    Location:909 → 1061
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl28904
    Location:1137 → 1366
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_039091071.2 → XP_038946999.1  receptor-type tyrosine-protein phosphatase V isoform X4

    UniProtKB/TrEMBL
    A6ICD7
    Conserved Domains (5) summary
    smart00060
    Location:473 → 547
    FN3; Fibronectin type 3 domain
    cd00063
    Location:656 → 725
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:148 → 201
    fn3; Fibronectin type III domain
    pfam18861
    Location:950 → 1102
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
    cl28904
    Location:1178 → 1351
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64612.1 GenPept UniProtKB/Swiss-Prot:Q64612

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