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Slc22a23 solute carrier family 22, member 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64559, updated on 2-Nov-2024

Summary

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Official Symbol
Slc22a23provided by RGD
Official Full Name
solute carrier family 22, member 23provided by RGD
Primary source
RGD:620302
See related
EnsemblRapid:ENSRNOG00000017210 AllianceGenome:RGD:620302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nritp
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Orthologous to human SLC22A23 (solute carrier family 22 member 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 286.6), Kidney (RPKM 279.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc22a23 in Genome Data Viewer
Location:
17p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (30749445..30915139)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30544106..30709790)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (31236015..31403685)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 50, member B Neighboring gene PX domain containing 1 Neighboring gene uncharacterized LOC134482704 Neighboring gene uncharacterized LOC120097753 Neighboring gene proteasome assembly chaperone 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume. Uchimura Y, et al. PLoS One, 2024. PMID 39197039, Free PMC Article
  2. Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23. Bennett KM, et al. Mol Cell Biochem, 2011 Jun. PMID 21359964, Free PMC Article
  3. Expression of the GDNF family members and their receptors in the mature rat cochlea. Stöver T, et al. Brain Res Mol Brain Res, 2000 Mar 10. PMID 10719212
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.
    Title: Knockout of the orphan membrane transporter Slc22a23 leads to a lean and hyperactive phenotype with a small hippocampal volume.
  2. These novel family members have a nonconserved amino terminus, relative to other organic cation transporters, that may preclude typical SLC22 transport function
    Title: Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 23
Names
ion transporter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022624.1 → NP_072146.1  solute carrier family 22 member 23

    See identical proteins and their annotated locations for NP_072146.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q9QZG1
    UniProtKB/TrEMBL
    A0A8I6AGL6
    Related
    ENSRNOP00000023149.5, ENSRNOT00000023149.7
    Conserved Domains (1) summary
    cd17444
    Location:187 → 608
    MFS_SLC22A23; Solute carrier family 22, member 23 of the Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    30749445..30915139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253845.5 → XP_006253907.1  solute carrier family 22 member 23 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABT6, A0A8I6AGL6
    Related
    ENSRNOP00000090447.1, ENSRNOT00000099248.2
    Conserved Domains (2) summary
    cd06174
    Location:230 → 359
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:98 → 623
    2A0119; cation transport protein

  2. XM_039096053.2 → XP_038951981.1  solute carrier family 22 member 23 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:134 → 493
    MFS; Major Facilitator Superfamily

  3. XM_063276724.1 → XP_063132794.1  solute carrier family 22 member 23 isoform X3

  4. XM_063276725.1 → XP_063132795.1  solute carrier family 22 member 23 isoform X4

  5. XM_063276726.1 → XP_063132796.1  solute carrier family 22 member 23 isoform X5

  6. XM_063276727.1 → XP_063132797.1  solute carrier family 22 member 23 isoform X6

RNA

  1. XR_010058929.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZG1.2 GenPept UniProtKB/Swiss-Prot:Q9QZG1

Gene LinkOut

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