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Spef2 sperm flagellar 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64555, updated on 2-Nov-2024

Summary

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Symbol
Spef2provided by RGD
Full Name
sperm flagellar 2provided by RGD
Primary source
RGD:620450
See related
EnsemblRapid:ENSRNOG00000058275 AllianceGenome:RGD:620450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kpl2
Summary
Predicted to enable protein dimerization activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including brain morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and sperm flagellum assembly. Predicted to be located in Golgi apparatus and sperm flagellum. Predicted to be active in manchette and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 39.0), Lung (RPKM 24.1) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spef2 in Genome Data Viewer
Location:
2q16
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (60239655..60421850, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (58512489..58694718, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (58901937..59084194, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene calcyphosine-like Neighboring gene interleukin 7 receptor Neighboring gene E3 SUMO-protein ligase KIAA1586-like Neighboring gene uncharacterized LOC120100738 Neighboring gene uncharacterized LOC120100559 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of KPL2, a novel gene induced during ciliogenesis of tracheal epithelial cells. Ostrowski LE, et al. Am J Respir Cell Mol Biol, 1999 Apr. PMID 10100999
  2. Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein. Sironen A, et al. Biol Reprod, 2010 Mar. PMID 19889948
  3. Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia. Sironen A, et al. Biol Reprod, 2011 Oct. PMID 21715716, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebrospinal fluid circulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mucociliary clearance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within respiratory system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm axoneme assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in sperm axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within sperm flagellum assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in manchette IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in manchette ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in sperm midpiece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sperm flagellar protein 2
Names
sperm flagellar protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415008.1 → NP_001401937.1  sperm flagellar protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2JXL6
    Related
    ENSRNOP00000070321.2, ENSRNOT00000086323.3

  2. NM_001415009.1 → NP_001401938.1  sperm flagellar protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  3. NM_022620.2 → NP_072142.2  sperm flagellar protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    60239655..60421850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103075.2 → XP_038959003.1  sperm flagellar protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q4V8M1, Q9R095
    Conserved Domains (2) summary
    pfam06294
    Location:5 → 97
    CH_2; CH-like domain in sperm protein
    cl17190
    Location:616 → 799
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. XM_063282495.1 → XP_063138565.1  sperm flagellar protein 2 isoform X2

  3. XM_063282493.1 → XP_063138563.1  sperm flagellar protein 2 isoform X1

  4. XM_039103076.2 → XP_038959004.1  sperm flagellar protein 2 isoform X4

    UniProtKB/TrEMBL
    A6KGK0
    Conserved Domains (1) summary
    cl17190
    Location:438 → 621
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  5. XM_039103077.2 → XP_038959005.1  sperm flagellar protein 2 isoform X6

    UniProtKB/TrEMBL
    A6KGK0
    Conserved Domains (1) summary
    cl17190
    Location:177 → 360
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  6. XM_063282496.1 → XP_063138566.1  sperm flagellar protein 2 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R095.2 GenPept UniProtKB/Swiss-Prot:Q9R095

Gene LinkOut

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