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Tep1 telomerase associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64523, updated on 28-Oct-2024

Summary

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Official Symbol
Tep1provided by RGD
Official Full Name
telomerase associated protein 1provided by RGD
Primary source
RGD:3869
See related
EnsemblRapid:ENSRNOG00000051706 AllianceGenome:RGD:3869
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tlp1
Summary
Contributes to telomerase activity. Predicted to be involved in telomere maintenance via recombination. Part of telomerase holoenzyme complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and stomach cancer. Orthologous to human TEP1 (telomerase associated protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 197.3), Heart (RPKM 107.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tep1 in Genome Data Viewer
Location:
15p14
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (26519429..26567073, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24045876..24093526, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (27751186..27798839, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cyclin B1 interacting protein 1 Neighboring gene small nucleolar RNA SNORD126 Neighboring gene poly (ADP-ribose) polymerase 2 Neighboring gene ribonuclease P RNA component H1 Neighboring gene kelch-like family member 33 Neighboring gene U6 spliceosomal RNA Neighboring gene O-sialoglycoprotein endopeptidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA location and modeling of a WD40 repeat domain within the vault. Kong LB, et al. RNA, 2000 Jun. PMID 10864046, Free PMC Article
  2. Recombinant human tumor necrosis factor alpha constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets. Megyeri P, et al. Neurosci Lett, 1992 Dec 14. PMID 1300486
  3. Two genetic variants in telomerase-associated protein 1 are associated with stomach cancer risk. Jin DH, et al. J Hum Genet, 2016 Oct. PMID 27305982
  4. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Liu Y, et al. Mol Cell Biol, 2000 Nov. PMID 11027287, Free PMC Article
  5. Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. Koyanagi Y, et al. Anticancer Res, 2000 Mar-Apr. PMID 10810353

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomerase RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to telomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to telomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables telomerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to telomerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA-templated DNA biosynthetic process IC
Inferred by Curator
more info
 PubMed 
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of telomerase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of telomerase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of telomerase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
telomerase protein component 1
Names
p230
p240
p80 telomerase homolog
rTLP1
telomerase protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022591.2 → NP_072113.1  telomerase protein component 1

    See identical proteins and their annotated locations for NP_072113.1

    Status: PROVISIONAL

    Source sequence(s)
    U89282
    UniProtKB/Swiss-Prot
    O08653
    UniProtKB/TrEMBL
    A6KEB2, F1LPX8
    Related
    ENSRNOP00000073225.1, ENSRNOT00000079506.3
    Conserved Domains (8) summary
    COG2319
    Location:1764 → 2201
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:1983 → 2276
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05386
    Location:91 → 119
    TEP1_N; TEP1 N-terminal domain
    pfam05729
    Location:1175 → 1350
    NACHT; NACHT domain
    pfam05731
    Location:234 → 689
    TROVE; TROVE domain
    pfam13271
    Location:921 → 1021
    DUF4062; Domain of unknown function (DUF4062)
    sd00039
    Location:2076 → 2113
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:1691 → 1966
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    26519429..26567073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093640.2 → XP_038949568.1  telomerase protein component 1 isoform X1

    Conserved Domains (5) summary
    cd00200
    Location:1129 → 1422
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1222 → 1259
    7WD40; WD40 repeat [structural motif]
    pfam05729
    Location:321 → 496
    NACHT; NACHT domain
    pfam13271
    Location:59 → 167
    DUF4062; Domain of unknown function (DUF4062)
    cl29593
    Location:837 → 1112
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039093642.1 → XP_038949570.1  telomerase protein component 1 isoform X3

    Conserved Domains (3) summary
    cd00200
    Location:670 → 963
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:763 → 800
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:378 → 653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_039093641.2 → XP_038949569.1  telomerase protein component 1 isoform X2

    UniProtKB/TrEMBL
    A6KEB3
    Conserved Domains (4) summary
    pfam05386
    Location:91 → 119
    TEP1_N; TEP1 N-terminal domain
    pfam05729
    Location:1175 → 1350
    NACHT; NACHT domain
    pfam05731
    Location:234 → 689
    TROVE; TROVE domain
    pfam13271
    Location:913 → 1021
    DUF4062; Domain of unknown function (DUF4062)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08653.1 GenPept UniProtKB/Swiss-Prot:O08653

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