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CCNI2 cyclin I family member 2 [ Homo sapiens (human) ]

Gene ID: 645121, updated on 5-Mar-2024

Summary

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Official Symbol
CCNI2provided by HGNC
Official Full Name
cyclin I family member 2provided by HGNC
Primary source
HGNC:HGNC:33869
See related
Ensembl:ENSG00000205089 MIM:620419; AllianceGenome:HGNC:33869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 13.3), adrenal (RPKM 2.6) and 18 other tissues See more
Orthologs
all
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Genomic context

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See CCNI2 in Genome Data Viewer
Location:
5q31.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132747426..132756065)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133267163..133275992)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132083118..132090095)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene kinesin family member 3A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23096 Neighboring gene septin 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16337 Neighboring gene Sharpr-MPRA regulatory region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150138-132150638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150639-132151139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16341 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16343 Neighboring gene shroom family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CCNI2 plays a promoting role in the progression of colorectal cancer. Lai DM, et al. Cancer Med, 2021 Mar. PMID 33620152, Free PMC Article
  2. Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes. Taneera J, et al. Mol Cell Endocrinol, 2013 Aug 15. PMID 23707792
  3. Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation. Liu C, et al. Sci Rep, 2017 Jan 23. PMID 28112194, Free PMC Article
  4. Combinatorial CRISPR screen identifies fitness effects of gene paralogues. Thompson NA, et al. Nat Commun, 2021 Feb 26. PMID 33637726, Free PMC Article
  5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-I2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039780.4 → NP_001034869.1  cyclin-I2 isoform 2

    See identical proteins and their annotated locations for NP_001034869.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC004775, AK131553, AW131382
    Consensus CDS
    CCDS34236.1
    UniProtKB/Swiss-Prot
    B2RNE2, B7ZMB7, B7ZMB8, Q6ZMN8
    Related
    ENSP00000368005.1, ENST00000378731.6
    Conserved Domains (2) summary
    pfam00134
    Location:156 → 247
    Cyclin_N; Cyclin, N-terminal domain
    cl26386
    Location:3 → 111
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  2. NM_001287252.2 → NP_001274181.1  cyclin-I2 isoform 1

    See identical proteins and their annotated locations for NP_001274181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004775, AK131553, AW131382, BC144417
    Consensus CDS
    CCDS75297.1
    UniProtKB/Swiss-Prot
    Q6ZMN8
    Related
    ENSP00000478257.1, ENST00000614847.1
    Conserved Domains (1) summary
    pfam00134
    Location:156 → 247
    Cyclin_N; Cyclin, N-terminal domain

  3. NM_001287253.2 → NP_001274182.1  cyclin-I2 isoform 3

    See identical proteins and their annotated locations for NP_001274182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC004775, AK131553, AW131382, BC144416
    UniProtKB/Swiss-Prot
    Q6ZMN8
    Conserved Domains (1) summary
    pfam00134
    Location:157 → 248
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    132747426..132756065
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417523.1 → XP_047273479.1  cyclin-I2 isoform X3

  2. XM_047417522.1 → XP_047273478.1  cyclin-I2 isoform X2

  3. XM_047417521.1 → XP_047273477.1  cyclin-I2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    133267163..133275992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353138.1 → XP_054209113.1  cyclin-I2 isoform X3

  2. XM_054353137.1 → XP_054209112.1  cyclin-I2 isoform X2

  3. XM_054353136.1 → XP_054209111.1  cyclin-I2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZMN8.1 GenPept UniProtKB/Swiss-Prot:Q6ZMN8

Gene LinkOut

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