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Timm10 translocase of inner mitochondrial membrane 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64464, updated on 2-Nov-2024

Summary

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Official Symbol
Timm10provided by RGD
Official Full Name
translocase of inner mitochondrial membrane 10provided by RGD
Primary source
RGD:621741
See related
EnsemblRapid:ENSRNOG00000007883 AllianceGenome:RGD:621741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tim10
Summary
Predicted to enable membrane insertase activity; protein homodimerization activity; and protein-folding chaperone binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human TIMM10 (translocase of inner mitochondrial membrane 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 295.5), Muscle (RPKM 173.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Timm10 in Genome Data Viewer
Location:
3q24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90315048..90318613)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69908397..69911943)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72226563..72230087)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 6 Neighboring gene smoothelin-like 1 Neighboring gene uncharacterized LOC120101592 Neighboring gene solute carrier family 43 member 1 Neighboring gene uncharacterized LOC102554396 Neighboring gene reticulon 4 receptor-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane. Adrian GS, et al. Mol Cell Biol, 1986 Feb. PMID 3023860, Free PMC Article
  2. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Webb CT, et al. Mol Cell, 2006 Jan 6. PMID 16387659
  3. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
  4. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
  5. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial intermembrane space protein transporter complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim10
Names
small zinc finger-like protein
translocase of inner mitochondrial membrane 10 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001431423.1 → NP_001418352.1  mitochondrial import inner membrane translocase subunit Tim10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P62074, Q5BKD3
    UniProtKB/TrEMBL
    A6HMR8

  2. NM_001431424.1 → NP_001418353.1  mitochondrial import inner membrane translocase subunit Tim10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P62074, Q5BKD3
    UniProtKB/TrEMBL
    A6HMR8

  3. NM_172074.4 → NP_742071.1  mitochondrial import inner membrane translocase subunit Tim10

    See identical proteins and their annotated locations for NP_742071.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P62074, Q5BKD3
    UniProtKB/TrEMBL
    A6HMR8
    Conserved Domains (1) summary
    pfam02953
    Location:7 → 69
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90315048..90318613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234473.5 → XP_006234535.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

    Conserved Domains (1) summary
    pfam02953
    Location:7 → 69
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. XM_006234474.5 → XP_006234536.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

    Related
    ENSRNOP00000010619.3, ENSRNOT00000010619.6
    Conserved Domains (1) summary
    pfam02953
    Location:7 → 69
    zf-Tim10_DDP; Tim10/DDP family zinc finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62074.1 GenPept UniProtKB/Swiss-Prot:P62074

Gene LinkOut

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