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Gpr88 G-protein coupled receptor 88 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64443, updated on 2-Nov-2024

Summary

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Official Symbol
Gpr88provided by RGD
Official Full Name
G-protein coupled receptor 88provided by RGD
Primary source
RGD:61921
See related
EnsemblRapid:ENSRNOG00000026953 AllianceGenome:RGD:61921
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled photoreceptor activity; beta2-adrenergic receptor activity; and cytoskeletal motor activity. Predicted to be involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; motor learning; and phototransduction. Predicted to act upstream of or within locomotory behavior; neuromuscular process controlling balance; and neuronal action potential. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human GPR88 (G protein-coupled receptor 88). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 104.7), Spleen (RPKM 91.8) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr88 in Genome Data Viewer
Location:
2q42
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206876373..206885034, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204191443..204199576, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219258346..219263819, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100924 Neighboring gene uncharacterized LOC134485676 Neighboring gene uncharacterized LOC134485677 Neighboring gene cell division cycle 14A Neighboring gene uncharacterized LOC120100925

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease. Galet B, et al. J Psychiatry Neurosci, 2021 Jan 4. PMID 32667145, Free PMC Article
  2. Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization. Massart R, et al. J Comp Neurol, 2016 Oct 1. PMID 26918661
  3. Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats. Ingallinesi M, et al. Mol Psychiatry, 2015 Aug. PMID 25155879
  4. Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents. Massart R, et al. Eur J Neurosci, 2009 Aug. PMID 19656174
  5. Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat. Calderón-Zamora L, et al. Clin Exp Hypertens, 2017. PMID 28678544

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
    Title: G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
  2. Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure.
    Title: Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
  3. In the developing cortex, GPR88 shifts on the day of birth to the nuclei of neurons in layers V to II.
    Title: Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.
  4. Results suggest a role for Gpr88 in the regulation of cognitive and motor functions, and support its relevance to the pathophysiology and treatment of schizophrenia and other disorders involving dysfunction of the accumbens-striatal complex
    Title: Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
  5. GPR88 is confined to striatal medium spiny neurons and indicate that L-DOPA-mediated behavioural effects in hemiparkinsonian rats may involve normalization of striatal GPR88 levels
    Title: Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta2-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables beta2-adrenergic receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cytoskeletal motor activity ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of visible light IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in motor learning ISO
Inferred from Sequence Orthology
more info
  
involved_in motor learning ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuronal action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G protein-coupled receptor 88
Names
probable G-protein coupled receptor 88
striatum-specific G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031696.2 → NP_113884.1  G protein-coupled receptor 88

    See identical proteins and their annotated locations for NP_113884.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    206876373..206885034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103063.2 → XP_038958991.1  G protein-coupled receptor 88 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Related
    ENSRNOP00000100418.1, ENSRNOT00000141206.1
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_039103064.2 → XP_038958992.1  G protein-coupled receptor 88 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Related
    ENSRNOP00000038233.2, ENSRNOT00000037068.5
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_039103062.2 → XP_038958990.1  G protein-coupled receptor 88 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_039103061.2 → XP_038958989.1  G protein-coupled receptor 88 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Related
    ENSRNOP00000111907.1, ENSRNOT00000167227.1
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_006233222.5 → XP_006233284.1  G protein-coupled receptor 88 isoform X1

    See identical proteins and their annotated locations for XP_006233284.1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. XM_006233221.5 → XP_006233283.1  G protein-coupled receptor 88 isoform X1

    See identical proteins and their annotated locations for XP_006233283.1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Related
    ENSRNOP00000101034.1, ENSRNOT00000129009.1
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. XM_006233220.5 → XP_006233282.1  G protein-coupled receptor 88 isoform X1

    See identical proteins and their annotated locations for XP_006233282.1

    UniProtKB/Swiss-Prot
    Q9ESP4
    UniProtKB/TrEMBL
    A6HV91
    Conserved Domains (2) summary
    cd14964
    Location:33 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 347
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESP4.1 GenPept UniProtKB/Swiss-Prot:Q9ESP4

Gene LinkOut

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