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St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64442, updated on 14-Nov-2024

Summary

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Official Symbol
St3gal2provided by RGD
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by RGD
Primary source
RGD:68413
See related
EnsemblRapid:ENSRNOG00000017932 AllianceGenome:RGD:68413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat5; Siat4b
Summary
Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Orthologous to human ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 149.0), Muscle (RPKM 140.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St3gal2 in Genome Data Viewer
Location:
19q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55798112..55849226)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38888851..38939874)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43273251..43324265, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 4 Neighboring gene fucose kinase Neighboring gene uncharacterized LOC134483368 Neighboring gene DEAD-box helicase 19A Neighboring gene DEAD-box helicase 19B Neighboring gene alanyl-tRNA synthetase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides. Chandrasekaran EV, et al. Biochemistry, 2011 Nov 8. PMID 21913655, Free PMC Article
  2. Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line. Giordanengo V, et al. Eur J Biochem, 1997 Jul 15. PMID 9266697
  3. Cloning and expression of cDNA for a new type of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase. Lee YC, et al. J Biol Chem, 1994 Apr 1. PMID 8144500
  4. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Kono M, et al. Glycobiology, 1997 Jun. PMID 9184827
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Use of sialyl mucin core 2 compounds shows how ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit, while also radiolabeling sialyl residues in gangliosides GD1a and GT1b, but not GM1.
    Title: Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
Inferred from Electronic Annotation
more info
  
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase ISO
Inferred from Sequence Orthology
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process via lactosylceramide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ganglioside biosynthetic process via lactosylceramide IEA
Inferred from Electronic Annotation
more info
  
involved_in ganglioside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in globoside biosynthetic process via lactosylceramide IEA
Inferred from Electronic Annotation
more info
  
involved_in globoside biosynthetic process via lactosylceramide ISO
Inferred from Sequence Orthology
more info
  
involved_in globoside biosynthetic process via lactosylceramide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoprotein biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sialylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
Names
SIAT4-B
ST3GALA.2
ST3Gal II
ST3GalII
alpha 2,3-ST 2
beta-galactoside alpha-2,3-sialyltransferase 2
gal-NAc6S
gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
monosialoganglioside sialyltransferase
sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase)
sialyltransferase 5
NP_113883.2
XP_006255687.1
XP_006255688.1
XP_006255689.1
XP_038953889.1
XP_038953890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031695.2 → NP_113883.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

    See identical proteins and their annotated locations for NP_113883.2

    Status: VALIDATED

    Source sequence(s)
    CO404237, EV769154, JAXUCZ010000019, X76988
    UniProtKB/Swiss-Prot
    Q11205
    UniProtKB/TrEMBL
    A6IZ75, G3V8B2
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    55798112..55849226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097961.2 → XP_038953889.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q11205
    UniProtKB/TrEMBL
    A6IZ75, G3V8B2
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_006255627.5 → XP_006255689.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006255689.1

    UniProtKB/Swiss-Prot
    Q11205
    UniProtKB/TrEMBL
    A6IZ75, G3V8B2
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  3. XM_006255625.5 → XP_006255687.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006255687.1

    UniProtKB/Swiss-Prot
    Q11205
    UniProtKB/TrEMBL
    A6IZ75, G3V8B2
    Related
    ENSRNOP00000024248.2, ENSRNOT00000024248.5
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  4. XM_006255626.5 → XP_006255688.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_006255688.1

    UniProtKB/Swiss-Prot
    Q11205
    UniProtKB/TrEMBL
    A6IZ75, G3V8B2
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  5. XM_039097962.2 → XP_038953890.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:11 → 237
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q11205.1 GenPept UniProtKB/Swiss-Prot:Q11205

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