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ZCCHC18 zinc finger CCHC-type containing 18 [ Homo sapiens (human) ]

Gene ID: 644353, updated on 5-Mar-2024

Summary

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Official Symbol
ZCCHC18provided by HGNC
Official Full Name
zinc finger CCHC-type containing 18provided by HGNC
Primary source
HGNC:HGNC:32459
See related
Ensembl:ENSG00000166707 AllianceGenome:HGNC:32459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIZN2; PNMA7B
Summary
Predicted to enable metal ion binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.7), brain (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

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See ZCCHC18 in Genome Data Viewer
Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (104112523..104115842)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102543724..102547043)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103357214..103360533)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene thymosin beta 15C Neighboring gene DPPA3 pseudogene 4 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103349345-103349844 Neighboring gene solute carrier family 25 member 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20923 Neighboring gene uncharacterized LOC286437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29826 Neighboring gene family with sequence similarity 199, X-linked Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:103410976-103411476

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of proteins that interact with murine cytomegalovirus early protein M112-113 in brain. Wang H, et al. Chin Med J (Engl), 2011 Nov. PMID 22340173
  2. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article
  3. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 18
Names
paraneoplastic Ma antigen family member 7B
putative zinc finger CCHC domain-containing protein 18
zinc finger, CCHC domain containing 12 pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143978.3 → NP_001137450.1  zinc finger CCHC domain-containing protein 18

    See identical proteins and their annotated locations for NP_001137450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AC234783, AI656548, DA781887, DA790216, DA808943
    Consensus CDS
    CCDS65304.1
    UniProtKB/Swiss-Prot
    P0CG32
    Related
    ENSP00000498828.1, ENST00000650639.1
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 212
    PNMA; PNMA

RNA

  1. NR_026694.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC234783, AI656548, CN272796, DA808943
    Related
    ENST00000422784.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    104112523..104115842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531012.4 → XP_011529314.1  zinc finger CCHC domain-containing protein 18 isoform X1

    See identical proteins and their annotated locations for XP_011529314.1

    UniProtKB/Swiss-Prot
    P0CG32
    Conserved Domains (1) summary
    pfam14893
    Location:1 → 212
    PNMA; PNMA

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102543724..102547043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327572.1 → XP_054183547.1  zinc finger CCHC domain-containing protein 18 isoform X1

    UniProtKB/Swiss-Prot
    P0CG32
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CG32.1 GenPept UniProtKB/Swiss-Prot:P0CG32

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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