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PCNX4 pecanex 4 [ Homo sapiens (human) ]

Gene ID: 64430, updated on 7-Apr-2024

Summary

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Official Symbol
PCNX4provided by HGNC
Official Full Name
pecanex 4provided by HGNC
Primary source
HGNC:HGNC:20349
See related
Ensembl:ENSG00000126773 AllianceGenome:HGNC:20349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP2; PCNXL4; C14orf135
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 4.7), endometrium (RPKM 4.5) and 25 other tissues See more
Orthologs
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Genomic context

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See PCNX4 in Genome Data Viewer
Location:
14q23.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60091911..60148221)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54297871..54354503)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60558629..60614939)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124167-60124668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60124669-60125168 Neighboring gene reticulon 1 Neighboring gene microRNA 5586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5807 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:60386022-60387221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8464 Neighboring gene leucine rich repeat containing 9 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:60459076-60459307 Neighboring gene PCNX4 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:60558835-60559468 Neighboring gene Sharpr-MPRA regulatory region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5808 Neighboring gene dehydrogenase/reductase 7 Neighboring gene short coiled-coil protein pseudogene 1 Neighboring gene proteasome subunit alpha 3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. Huang YP, et al. World J Gastroenterol, 2005 Sep 28. PMID 16237761, Free PMC Article
  2. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. Andreev DE, et al. Elife, 2015 Jan 26. PMID 25621764, Free PMC Article
  3. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
  4. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
  5. Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Lambert JP, et al. Mol Cell, 2019 Feb 7. PMID 30554943, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12799, FLJ38170

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pecanex-like protein 4
Names
HCV F protein-binding protein 2
HCV F-interacting protein
hepatitis C virus F protein-binding protein 2
pecanex homolog 4
pecanex homolog protein 4
pecanex-like 4
pecanex-like protein C14orf135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330177.2 → NP_001317106.1  pecanex-like protein 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA651916, AL157911, AL163853
    Consensus CDS
    CCDS81809.1
    UniProtKB/Swiss-Prot
    A8MXM2, Q63HM2, Q9BQG8, Q9H9F2
    Related
    ENSP00000384801.1, ENST00000406854.6

  2. NM_022495.5 → NP_071940.4  pecanex-like protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA651916, AK095489, AL157911, BC033843
    Consensus CDS
    CCDS32091.2
    UniProtKB/TrEMBL
    B5MC47, B6ZDM2
    Related
    ENSP00000317396.4, ENST00000317623.8
    Conserved Domains (1) summary
    pfam05041
    Location:831 → 930
    Pecanex_C; Pecanex protein (C-terminus)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    60091911..60148221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431699.1 → XP_047287655.1  pecanex-like protein 4 isoform X1

  2. XM_047431700.1 → XP_047287656.1  pecanex-like protein 4 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    54297871..54354503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376606.1 → XP_054232581.1  pecanex-like protein 4 isoform X1

  2. XM_054376607.1 → XP_054232582.1  pecanex-like protein 4 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63HM2.4 GenPept UniProtKB/Swiss-Prot:Q63HM2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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