U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WIPF3 WAS/WASL interacting protein family member 3 [ Homo sapiens (human) ]

Gene ID: 644150, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
WIPF3provided by HGNC
Official Full Name
WAS/WASL interacting protein family member 3provided by HGNC
Primary source
HGNC:HGNC:22004
See related
Ensembl:ENSG00000122574 MIM:612432; AllianceGenome:HGNC:22004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CR16
Summary
Predicted to enable alpha-tubulin binding activity and gamma-tubulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; endosomal transport; and exocytosis. Predicted to be located in cytosol. Predicted to be part of WASH complex. Predicted to be active in early endosome; recycling endosome; and synapse. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary (RPKM 20.0), testis (RPKM 14.2) and 10 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See WIPF3 in Genome Data Viewer
Location:
7p14.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (29806508..29917061)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (29944291..30054757)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29846124..29956677)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MIR550A3 host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18048 Neighboring gene DPY19L2 pseudogene 3 Neighboring gene microRNA 550a-3 Neighboring gene zinc and ring finger 2 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 13440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29823644-29824238 Neighboring gene hESC enhancers GRCh37_chr7:29832406-29833236 and GRCh37_chr7:29833237-29834066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:29845860-29846769 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25802 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:29894186-29894764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29922848-29923743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:29930193-29930732 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:29968955-29969454 Neighboring gene secernin 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:30000281-30001070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18052 Neighboring gene FKBP14 antisense RNA 1 Neighboring gene FKBP prolyl isomerase 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of ARMH4 and WIPF3 as human podocyte proteins with potential roles in immunomodulation and cytoskeletal dynamics.
    Title: Identification of ARMH4 and WIPF3 as human podocyte proteins with potential roles in immunomodulation and cytoskeletal dynamics.
  2. These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
    Title: Mammalian verprolin CR16 acts as a modulator of ITSN scaffold proteins association with actin.
  3. The expressions of the CR16 protein and mRNA decrease markedly in the testis of patients with idiopathic azoospermia.
    Title: [Expression of CR16 in the testis of patients with idiopathic azoospermia].
  4. CR16 and N-WASP are suggested to play important roles in spermatogenesis
    Title: Male-specific sterility caused by the loss of CR16.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants near PDGFRA are associated with corneal curvature in Australians.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ36931

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
WAS/WASL-interacting protein family member 3
Names
corticosteroids and regional expression protein 16 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080529.3 → NP_001073998.2  WAS/WASL-interacting protein family member 3 isoform 1

    See identical proteins and their annotated locations for NP_001073998.2

    Status: VALIDATED

    Source sequence(s)
    AC004912, AW105171, BX107905
    Consensus CDS
    CCDS56472.1
    UniProtKB/Swiss-Prot
    A6NGB9, B8ZZV2
    Related
    ENSP00000242140.6, ENST00000242140.10
    Conserved Domains (1) summary
    pfam02205
    Location:42 → 69
    WH2; WH2 motif

  2. NM_001391973.1 → NP_001378902.1  WAS/WASL-interacting protein family member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004912
    Consensus CDS
    CCDS94074.1
    UniProtKB/TrEMBL
    A0A0A0MSG0
    Related
    ENSP00000386790.1, ENST00000409123.5
    Conserved Domains (1) summary
    cd22077
    Location:42 → 71
    WH2_WAS_WASL-2_3; Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP) family members 2 and 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    29806508..29917061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012522.2 → XP_016868011.1  WAS/WASL-interacting protein family member 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    29944291..30054757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358802.1 → XP_054214777.1  WAS/WASL-interacting protein family member 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NGB9.4 GenPept UniProtKB/Swiss-Prot:A6NGB9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous