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ZFP62 ZFP62 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 643836, updated on 5-Mar-2024

Summary

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Official Symbol
ZFP62provided by HGNC
Official Full Name
ZFP62 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:23241
See related
Ensembl:ENSG00000196670 MIM:610281; AllianceGenome:HGNC:23241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZET; ZNF755
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Annotation of ZFP62 was placed on AC016572.6 on NCBI's annotation 36.3. This clone has been determined to be redundant, so the annotation was merged with the location on the assembled chromosome. [02 Mar 2009]
Expression
Ubiquitous expression in thyroid (RPKM 6.7), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180826870..180861276, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181399916..181417629, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180274611..180288276, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily Y member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212035-180212946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180212947-180213857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180224505-180225006 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr5:180229118-180229825 and GRCh37_chr5:180229826-180230532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23770 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180231240-180231945 Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23771 Neighboring gene Sharpr-MPRA regulatory region 14850 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16775 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16777 Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene Sharpr-MPRA regulatory region 9005 Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180288413-180289319 Neighboring gene uncharacterized LOC124901155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23773 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180334710-180335266 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180335267-180335821 Neighboring gene butyrophilin like 8 Neighboring gene ribosomal protein S29 pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Differentiation dependent expression in muscle cells of ZT3, a novel zinc finger factor differentially expressed in embryonic and adult tissues. Polimeni M, et al. Mech Dev, 1996 Jan. PMID 8808410
  2. Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. Yu LR, et al. J Proteome Res, 2007 Nov. PMID 17924679
  3. ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold. Yang W, et al. Theranostics, 2022. PMID 36168627, Free PMC Article
  4. SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk. Lukinović V, et al. Cancer Discov, 2022 Sep 2. PMID 35819319, Free PMC Article
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11344, FLJ34057, FLJ34231, FLJ58781, FLJ59694, MGC176438, DKFZp667F2013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 62 homolog
Names
zfp-62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172638.2 → NP_001166109.1  zinc finger protein 62 homolog isoform 2

    See identical proteins and their annotated locations for NP_001166109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS54955.1
    UniProtKB/Swiss-Prot
    B4DIP6, B4E0N3, B5MDX6, B7ZVZ2, B9EIP6, E9PFT8, J3QTA9, Q8NB50
    Related
    ENSP00000423820.1, ENST00000502412.2
    Conserved Domains (2) summary
    COG5048
    Location:447 → 860
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001377939.1 → NP_001364868.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS47357.2
    Conserved Domains (2) summary
    COG5048
    Location:414 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001377940.1 → NP_001364869.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS47357.2
    Conserved Domains (2) summary
    COG5048
    Location:414 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001377941.1 → NP_001364870.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS47357.2
    Conserved Domains (2) summary
    COG5048
    Location:414 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001377942.1 → NP_001364871.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS47357.2
    Conserved Domains (2) summary
    COG5048
    Location:414 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001377943.1 → NP_001364872.1  zinc finger protein 62 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022413
    UniProtKB/Swiss-Prot
    B4DIP6, B4E0N3, B5MDX6, B7ZVZ2, B9EIP6, E9PFT8, J3QTA9, Q8NB50
    Conserved Domains (2) summary
    COG5048
    Location:447 → 860
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001377944.1 → NP_001364873.1  zinc finger protein 62 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:363 → 776
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227 → 247
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001377945.1 → NP_001364874.1  zinc finger protein 62 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:330 → 743
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_152283.5 → NP_689496.4  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS47357.2
    UniProtKB/Swiss-Prot
    Q8NB50
    Related
    ENSP00000426193.1, ENST00000512132.5
    Conserved Domains (2) summary
    COG5048
    Location:414 → 827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194 → 214
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    180826870..180861276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417504.1 → XP_047273460.1  zinc finger protein 62 homolog isoform X9

  2. XM_047417501.1 → XP_047273457.1  zinc finger protein 62 homolog isoform X5

  3. XM_047417502.1 → XP_047273458.1  zinc finger protein 62 homolog isoform X7

  4. XM_017009716.3 → XP_016865205.1  zinc finger protein 62 homolog isoform X3

  5. XM_017009718.3 → XP_016865207.1  zinc finger protein 62 homolog isoform X4

  6. XM_047417499.1 → XP_047273455.1  zinc finger protein 62 homolog isoform X1

  7. XM_047417500.1 → XP_047273456.1  zinc finger protein 62 homolog isoform X2

  8. XM_047417503.1 → XP_047273459.1  zinc finger protein 62 homolog isoform X8

  9. XM_017009719.3 → XP_016865208.1  zinc finger protein 62 homolog isoform X6

RNA

  1. XR_007058623.1 RNA Sequence

  2. XR_007058622.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181399916..181417629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353106.1 → XP_054209081.1  zinc finger protein 62 homolog isoform X5

  2. XM_054353108.1 → XP_054209083.1  zinc finger protein 62 homolog isoform X7

  3. XM_054353104.1 → XP_054209079.1  zinc finger protein 62 homolog isoform X3

  4. XM_054353105.1 → XP_054209080.1  zinc finger protein 62 homolog isoform X4

  5. XM_054353101.1 → XP_054209076.1  zinc finger protein 62 homolog isoform X1

  6. XM_054353103.1 → XP_054209078.1  zinc finger protein 62 homolog isoform X2

  7. XM_054353109.1 → XP_054209084.1  zinc finger protein 62 homolog isoform X8

  8. XM_054353102.1 → XP_054209077.1  zinc finger protein 62 homolog isoform X10

  9. XM_054353107.1 → XP_054209082.1  zinc finger protein 62 homolog isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NB50.3 GenPept UniProtKB/Swiss-Prot:Q8NB50

Gene LinkOut

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