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FBRS fibrosin [ Homo sapiens (human) ]

Gene ID: 64319, updated on 5-Mar-2024

Summary

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Official Symbol
FBRSprovided by HGNC
Official Full Name
fibrosinprovided by HGNC
Primary source
HGNC:HGNC:20442
See related
Ensembl:ENSG00000156860 MIM:608601; AllianceGenome:HGNC:20442
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBS; FBS1
Summary
Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 34.3), bone marrow (RPKM 18.4) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
16p11.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (30658431..30670810)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (31045402..31057781)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30669752..30682131)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30621737-30622706 Neighboring gene uncharacterized LOC124903678 Neighboring gene zinc finger protein 689 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30626940-30627180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30644787-30645738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30645739-30646689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661003-30661520 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30661521-30662036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7384 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7387 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7388 Neighboring gene proline rich 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10718 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30681557-30681750 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30688172-30689072 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30689073-30689972 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:30689973-30690873 Neighboring gene RNA, U6 small nuclear 416, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:30693026-30693526 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:30697048-30697206 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:30705076-30705670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7389 Neighboring gene Sharpr-MPRA regulatory region 39 Neighboring gene uncharacterized LOC730183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts. Prakash S, et al. Exp Mol Pathol, 2007 Feb. PMID 17083929
  2. Fibrosin: a novel lymphokine in wound healing. Prakash S, et al. Exp Mol Pathol, 2001 Dec. PMID 11733950
  3. Fibrosin: A novel lymphokine in alcohol-induced fibrosis. Prakash S, et al. Exp Mol Pathol, 1999 Sep. PMID 10493891
  4. Cloning and analysis of the cDNA for human fibrosin, a novel fibrogenic lymphokine. Prakash S, et al. DNA Cell Biol, 1998 Oct. PMID 9809749
  5. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. Prakash S, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892239, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In a rat model, ethanol can directly stimulate fibroblast proliferation and production of fibrogenic cytokines, particularly fibrosin, which appears to contribute to alcohol-induced hepatic fibrosis in vivo.
    Title: Fibrosin: A novel lymphokine in alcohol-induced fibrosis.
  2. Characterization of mouse fibrosin and demonstration of growth-stimulating effects in fibroblasts.
    Title: Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin.
  3. In a mouse model, fibrosin upregulates the appearance of myofibroblasts during wound healing and may be important in the process of scarring.
    Title: Fibrosin, a novel fibrogenic cytokine, modulates expression of myofibroblasts.
  4. Fibrosin stimulates epithelialization of wounds in mouse and reduces wound healing time by approximately 30-40%.
    Title: Fibrosin: a novel lymphokine in wound healing.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11618

General protein information

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Preferred Names
probable fibrosin-1
Names
fibrogenic lymphokine
fibrosin 1
probable fibrosin-1 long transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105079.3 → NP_001098549.2  probable fibrosin-1

    Status: VALIDATED

    Source sequence(s)
    AC093249
    Consensus CDS
    CCDS45462.2
    UniProtKB/TrEMBL
    J3KNZ9
    Related
    ENSP00000348489.5, ENST00000356166.11
    Conserved Domains (1) summary
    pfam15336
    Location:602 → 802
    Auts2; Autism susceptibility gene 2 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    30658431..30670810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545916.3 → XP_011544218.1  probable fibrosin-1 isoform X2

    Conserved Domains (1) summary
    pfam15336
    Location:592 → 792
    Auts2; Autism susceptibility gene 2 protein

  2. XM_011545917.3 → XP_011544219.1  probable fibrosin-1 isoform X1

    Conserved Domains (1) summary
    pfam15336
    Location:592 → 792
    Auts2; Autism susceptibility gene 2 protein

  3. XM_047434483.1 → XP_047290439.1  probable fibrosin-1 isoform X3

  4. XM_011545919.3 → XP_011544221.1  probable fibrosin-1 isoform X4

    Conserved Domains (1) summary
    pfam15336
    Location:580 → 780
    Auts2; Autism susceptibility gene 2 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    31045402..31057781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313673.1 → XP_054169648.1  probable fibrosin-1 isoform X2

  2. XM_054313672.1 → XP_054169647.1  probable fibrosin-1 isoform X1

  3. XM_054313674.1 → XP_054169649.1  probable fibrosin-1 isoform X3

  4. XM_054313675.1 → XP_054169650.1  probable fibrosin-1 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022452.1: Suppressed sequence

    Description
    NM_022452.1: This RefSeq was permanently suppressed because the CDS was partial.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9HAH7.3 GenPept UniProtKB/Swiss-Prot:Q9HAH7

Gene LinkOut

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