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NPIPA2 nuclear pore complex interacting protein family member A2 [ Homo sapiens (human) ]

Gene ID: 642799, updated on 3-Apr-2024

Summary

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Official Symbol
NPIPA2provided by HGNC
Official Full Name
nuclear pore complex interacting protein family member A2provided by HGNC
Primary source
HGNC:HGNC:41979
See related
Ensembl:ENSG00000254852 AllianceGenome:HGNC:41979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPIP; NPIPA1
Summary
Predicted to be involved in mRNA transport and protein transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 20.2), testis (RPKM 15.4) and 25 other tissues See more
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Genomic context

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Location:
16p13.11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (14742533..14765462)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (14740934..14763869)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (14836390..14859319)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group X Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14781374-14781874 Neighboring gene group 10 secretory phospholipase A2 Neighboring gene nuclear pore complex interacting protein family member A3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:14860458-14860958 Neighboring gene phospholipase A2 group XE, pseudogene Neighboring gene ATP binding cassette subfamily C member 6 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling. Hornan DM, et al. Invest Ophthalmol Vis Sci, 2007 Dec. PMID 18055785
  2. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

General protein information

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Preferred Names
nuclear pore complex-interacting protein family member A2
Names
Nuclear pore complex-interacting protein family member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277324.3 → NP_001264253.1  nuclear pore complex-interacting protein family member A2 isoform 2

    See identical proteins and their annotated locations for NP_001264253.1

    Status: VALIDATED

    Source sequence(s)
    AC136443
    Consensus CDS
    CCDS59263.1
    UniProtKB/TrEMBL
    A0A067ZUL9, A0A0B4J2F6
    Conserved Domains (1) summary
    pfam06409
    Location:22 → 287
    NPIP; Nuclear pore complex interacting protein (NPIP)

  2. NM_001395485.2 → NP_001382414.1  nuclear pore complex-interacting protein family member A2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC136443
    Consensus CDS
    CCDS92115.1
    UniProtKB/Swiss-Prot
    E9PIF3
    UniProtKB/TrEMBL
    A0A067ZUL9
    Related
    ENSP00000432029.1, ENST00000529166.6
    Conserved Domains (2) summary
    pfam06409
    Location:46 → 307
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. NM_001395486.2 → NP_001382415.1  nuclear pore complex-interacting protein family member A2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC136443
    Consensus CDS
    CCDS92115.1
    UniProtKB/Swiss-Prot
    E9PIF3
    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (2) summary
    pfam06409
    Location:46 → 307
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    14742533..14765462
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434472.1 → XP_047290428.1  nuclear pore complex-interacting protein family member A2 isoform X3

    UniProtKB/Swiss-Prot
    E9PIF3

  2. XM_024450385.2 → XP_024306153.1  nuclear pore complex-interacting protein family member A2 isoform X3

    UniProtKB/Swiss-Prot
    E9PIF3
    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (2) summary
    pfam06409
    Location:46 → 307
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:2 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. XM_024450383.2 → XP_024306151.1  nuclear pore complex-interacting protein family member A2 isoform X1

    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 269
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  4. XM_024450381.2 → XP_024306149.1  nuclear pore complex-interacting protein family member A2 isoform X1

    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 269
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  5. XM_006720917.5 → XP_006720980.2  nuclear pore complex-interacting protein family member A2 isoform X7

    See identical proteins and their annotated locations for XP_006720980.2

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 262
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  6. XM_011522595.3 → XP_011520897.1  nuclear pore complex-interacting protein family member A2 isoform X8

    See identical proteins and their annotated locations for XP_011520897.1

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 266
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  7. XM_011522594.4 → XP_011520896.1  nuclear pore complex-interacting protein family member A2 isoform X7

    See identical proteins and their annotated locations for XP_011520896.1

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 262
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  8. XM_011522593.2 → XP_011520895.1  nuclear pore complex-interacting protein family member A2 isoform X7

    See identical proteins and their annotated locations for XP_011520895.1

    UniProtKB/TrEMBL
    A0A067ZWN6
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 262
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  9. XM_024450382.2 → XP_024306150.1  nuclear pore complex-interacting protein family member A2 isoform X1

    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (2) summary
    pfam06409
    Location:70 → 269
    NPIP; Nuclear pore complex interacting protein (NPIP)
    cl17068
    Location:1 → 41
    AFD_class_I; Adenylate forming domain, Class I superfamily

  10. XM_047434473.1 → XP_047290429.1  nuclear pore complex-interacting protein family member A2 isoform X5

    UniProtKB/TrEMBL
    A0A0B4J2F6
    Related
    ENSP00000446882.1, ENST00000553201.1

  11. XM_005255492.4 → XP_005255549.1  nuclear pore complex-interacting protein family member A2 isoform X10

    See identical proteins and their annotated locations for XP_005255549.1

    UniProtKB/TrEMBL
    A0A067ZVG2, A0A067ZWN8, O15103
    Conserved Domains (1) summary
    pfam06409
    Location:22 → 214
    NPIP; Nuclear pore complex interacting protein (NPIP)

  12. XM_024450384.2 → XP_024306152.1  nuclear pore complex-interacting protein family member A2 isoform X2

    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (1) summary
    pfam06409
    Location:49 → 248
    NPIP; Nuclear pore complex interacting protein (NPIP)

  13. XM_047434474.1 → XP_047290430.1  nuclear pore complex-interacting protein family member A2 isoform X6

  14. XM_024450388.2 → XP_024306156.1  nuclear pore complex-interacting protein family member A2 isoform X4

    UniProtKB/TrEMBL
    A0A067ZUL9
    Conserved Domains (1) summary
    pfam06409
    Location:26 → 225
    NPIP; Nuclear pore complex interacting protein (NPIP)

  15. XM_011522596.1 → XP_011520898.1  nuclear pore complex-interacting protein family member A2 isoform X9

    See identical proteins and their annotated locations for XP_011520898.1

    UniProtKB/TrEMBL
    H0YED6
    Conserved Domains (1) summary
    pfam06409
    Location:26 → 245
    NPIP; Nuclear pore complex interacting protein (NPIP)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    14740934..14763869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313647.1 → XP_054169622.1  nuclear pore complex-interacting protein family member A2 isoform X1

  2. XM_054313653.1 → XP_054169628.1  nuclear pore complex-interacting protein family member A2 isoform X7

  3. XM_054313655.1 → XP_054169630.1  nuclear pore complex-interacting protein family member A2 isoform X8

  4. XM_054313654.1 → XP_054169629.1  nuclear pore complex-interacting protein family member A2 isoform X7

  5. XM_054313652.1 → XP_054169627.1  nuclear pore complex-interacting protein family member A2 isoform X7

  6. XM_054313650.1 → XP_054169625.1  nuclear pore complex-interacting protein family member A2 isoform X5

  7. XM_054313657.1 → XP_054169632.1  nuclear pore complex-interacting protein family member A2 isoform X10

    UniProtKB/TrEMBL
    O15103

  8. XM_054313648.1 → XP_054169623.1  nuclear pore complex-interacting protein family member A2 isoform X2

  9. XM_054313651.1 → XP_054169626.1  nuclear pore complex-interacting protein family member A2 isoform X6

  10. XM_054313649.1 → XP_054169624.1  nuclear pore complex-interacting protein family member A2 isoform X4

  11. XM_054313656.1 → XP_054169631.1  nuclear pore complex-interacting protein family member A2 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PIF3.1 GenPept UniProtKB/Swiss-Prot:E9PIF3

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