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MROH6 maestro heat like repeat family member 6 [ Homo sapiens (human) ]

Gene ID: 642475, updated on 5-Mar-2024

Summary

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Official Symbol
MROH6provided by HGNC
Official Full Name
maestro heat like repeat family member 6provided by HGNC
Primary source
HGNC:HGNC:27814
See related
Ensembl:ENSG00000204839 AllianceGenome:HGNC:27814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C8orf73
Expression
Broad expression in bone marrow (RPKM 5.5), esophagus (RPKM 4.2) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
8q24.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143566192..143572772, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144715587..144723834, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144648362..144654942, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144631415-144632004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144632005-144632593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144635671-144636416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144636417-144637160 Neighboring gene uncharacterized LOC100310756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144640331-144640972 Neighboring gene gasdermin D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144653451-144654300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144659908-144660815 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144660816-144661724 Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144671257-144671758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144671759-144672258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144678233-144678832

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Büssow K, et al. Nucleic Acids Res, 1998 Nov 1. PMID 9776767, Free PMC Article
  2. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, et al. Mol Cell, 2019 Feb 21. PMID 30639242, Free PMC Article
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. Kırlı K, et al. Elife, 2015 Dec 17. PMID 26673895, Free PMC Article
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
maestro heat-like repeat-containing protein family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100878.2 → NP_001094348.1  maestro heat-like repeat-containing protein family member 6

    See identical proteins and their annotated locations for NP_001094348.1

    Status: VALIDATED

    Source sequence(s)
    AC067930, AL040647, BC029031, BM148864, BX341537, CD579780, DB003146, DN831781
    Consensus CDS
    CCDS47928.1
    UniProtKB/Swiss-Prot
    A6NGR9, A8MWB1
    Related
    ENSP00000381857.3, ENST00000398882.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    143566192..143572772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422096.1 → XP_047278052.1  maestro heat-like repeat-containing protein family member 6 isoform X15

  2. XM_047422095.1 → XP_047278051.1  maestro heat-like repeat-containing protein family member 6 isoform X14

  3. XM_047422092.1 → XP_047278048.1  maestro heat-like repeat-containing protein family member 6 isoform X10

  4. XM_047422093.1 → XP_047278049.1  maestro heat-like repeat-containing protein family member 6 isoform X12

  5. XM_011517215.2 → XP_011515517.1  maestro heat-like repeat-containing protein family member 6 isoform X2

    See identical proteins and their annotated locations for XP_011515517.1

    Conserved Domains (1) summary
    PHA03247
    Location:636 → 740
    PHA03247; large tegument protein UL36; Provisional

  6. XM_047422094.1 → XP_047278050.1  maestro heat-like repeat-containing protein family member 6 isoform X13

  7. XM_011517223.2 → XP_011515525.1  maestro heat-like repeat-containing protein family member 6 isoform X11

    See identical proteins and their annotated locations for XP_011515525.1

    Conserved Domains (1) summary
    pfam02063
    Location:2 → 105
    MARCKS; MARCKS family

  8. XM_011517222.2 → XP_011515524.1  maestro heat-like repeat-containing protein family member 6 isoform X8

    See identical proteins and their annotated locations for XP_011515524.1

    Conserved Domains (1) summary
    pfam02063
    Location:2 → 105
    MARCKS; MARCKS family

  9. XM_011517217.2 → XP_011515519.1  maestro heat-like repeat-containing protein family member 6 isoform X4

    See identical proteins and their annotated locations for XP_011515519.1

  10. XM_011517216.3 → XP_011515518.1  maestro heat-like repeat-containing protein family member 6 isoform X3

    See identical proteins and their annotated locations for XP_011515518.1

    Conserved Domains (1) summary
    PHA02682
    Location:639 → 728
    PHA02682; ORF080 virion core protein; Provisional

  11. XM_011517214.2 → XP_011515516.1  maestro heat-like repeat-containing protein family member 6 isoform X1

    See identical proteins and their annotated locations for XP_011515516.1

    Conserved Domains (1) summary
    PHA03247
    Location:637 → 741
    PHA03247; large tegument protein UL36; Provisional

  12. XM_047422089.1 → XP_047278045.1  maestro heat-like repeat-containing protein family member 6 isoform X7

  13. XM_011517221.3 → XP_011515523.1  maestro heat-like repeat-containing protein family member 6 isoform X6

    See identical proteins and their annotated locations for XP_011515523.1

    Conserved Domains (1) summary
    pfam02063
    Location:2 → 105
    MARCKS; MARCKS family

  14. XM_047422090.1 → XP_047278046.1  maestro heat-like repeat-containing protein family member 6 isoform X9

  15. XM_047422097.1 → XP_047278053.1  maestro heat-like repeat-containing protein family member 6 isoform X17

    Related
    ENSP00000436959.1, ENST00000529971.1

  16. XM_006716615.3 → XP_006716678.1  maestro heat-like repeat-containing protein family member 6 isoform X16

    See identical proteins and their annotated locations for XP_006716678.1

    Conserved Domains (1) summary
    pfam02063
    Location:2 → 105
    MARCKS; MARCKS family

  17. XM_011517220.2 → XP_011515522.1  maestro heat-like repeat-containing protein family member 6 isoform X5

    See identical proteins and their annotated locations for XP_011515522.1

    Conserved Domains (1) summary
    pfam02063
    Location:2 → 105
    MARCKS; MARCKS family

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    56232..64478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328769.1 → XP_054184744.1  maestro heat-like repeat-containing protein family member 6 isoform X15

  2. XM_054328766.1 → XP_054184741.1  maestro heat-like repeat-containing protein family member 6 isoform X12

  3. XM_054328756.1 → XP_054184731.1  maestro heat-like repeat-containing protein family member 6 isoform X2

  4. XM_054328765.1 → XP_054184740.1  maestro heat-like repeat-containing protein family member 6 isoform X11

  5. XM_054328762.1 → XP_054184737.1  maestro heat-like repeat-containing protein family member 6 isoform X8

  6. XM_054328758.1 → XP_054184733.1  maestro heat-like repeat-containing protein family member 6 isoform X4

  7. XM_054328757.1 → XP_054184732.1  maestro heat-like repeat-containing protein family member 6 isoform X3

  8. XM_054328768.1 → XP_054184743.1  maestro heat-like repeat-containing protein family member 6 isoform X14

  9. XM_054328764.1 → XP_054184739.1  maestro heat-like repeat-containing protein family member 6 isoform X10

  10. XM_054328767.1 → XP_054184742.1  maestro heat-like repeat-containing protein family member 6 isoform X13

  11. XM_054328761.1 → XP_054184736.1  maestro heat-like repeat-containing protein family member 6 isoform X7

  12. XM_054328760.1 → XP_054184735.1  maestro heat-like repeat-containing protein family member 6 isoform X6

  13. XM_054328763.1 → XP_054184738.1  maestro heat-like repeat-containing protein family member 6 isoform X9

  14. XM_054328771.1 → XP_054184746.1  maestro heat-like repeat-containing protein family member 6 isoform X17

  15. XM_054328770.1 → XP_054184745.1  maestro heat-like repeat-containing protein family member 6 isoform X16

  16. XM_054328759.1 → XP_054184734.1  maestro heat-like repeat-containing protein family member 6 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    144715587..144723834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361000.1 → XP_054216975.1  maestro heat-like repeat-containing protein family member 6 isoform X15

  2. XM_054360995.1 → XP_054216970.1  maestro heat-like repeat-containing protein family member 6 isoform X12

  3. XM_054360982.1 → XP_054216957.1  maestro heat-like repeat-containing protein family member 6 isoform X2

  4. XM_054360994.1 → XP_054216969.1  maestro heat-like repeat-containing protein family member 6 isoform X11

  5. XM_054360990.1 → XP_054216965.1  maestro heat-like repeat-containing protein family member 6 isoform X8

  6. XM_054360985.1 → XP_054216960.1  maestro heat-like repeat-containing protein family member 6 isoform X4

  7. XM_054360983.1 → XP_054216958.1  maestro heat-like repeat-containing protein family member 6 isoform X18

  8. XM_054360984.1 → XP_054216959.1  maestro heat-like repeat-containing protein family member 6 isoform X3

  9. XM_054360999.1 → XP_054216974.1  maestro heat-like repeat-containing protein family member 6 isoform X14

  10. XM_054360992.1 → XP_054216967.1  maestro heat-like repeat-containing protein family member 6 isoform X10

  11. XM_054360998.1 → XP_054216973.1  maestro heat-like repeat-containing protein family member 6 isoform X13

  12. XM_054360997.1 → XP_054216972.1  maestro heat-like repeat-containing protein family member 6 isoform X21

  13. XM_054360989.1 → XP_054216964.1  maestro heat-like repeat-containing protein family member 6 isoform X7

  14. XM_054360996.1 → XP_054216971.1  maestro heat-like repeat-containing protein family member 6 isoform X20

  15. XM_054360993.1 → XP_054216968.1  maestro heat-like repeat-containing protein family member 6 isoform X19

  16. XM_054360988.1 → XP_054216963.1  maestro heat-like repeat-containing protein family member 6 isoform X6

  17. XM_054360991.1 → XP_054216966.1  maestro heat-like repeat-containing protein family member 6 isoform X9

  18. XM_054361001.1 → XP_054216976.1  maestro heat-like repeat-containing protein family member 6 isoform X16

  19. XM_054360986.1 → XP_054216961.1  maestro heat-like repeat-containing protein family member 6 isoform X5

  20. XM_054360987.1 → XP_054216962.1  maestro heat-like repeat-containing protein family member 6 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NGR9.2 GenPept UniProtKB/Swiss-Prot:A6NGR9

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