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Bcat2 branched chain amino acid transaminase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64203, updated on 5-Nov-2024

Summary

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Official Symbol
Bcat2provided by RGD
Official Full Name
branched chain amino acid transaminase 2provided by RGD
Primary source
RGD:68948
See related
EnsemblRapid:ENSRNOG00000020956 AllianceGenome:RGD:68948
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
BCT2; Bcatm; mBcat
Summary
Enables branched-chain-amino-acid transaminase activity. Involved in L-leucine biosynthetic process; isoleucine catabolic process; and lactation. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to human BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 209.9), Kidney (RPKM 172.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bcat2 in Genome Data Viewer
Location:
1q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105175157..105196474)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96040407..96060008)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101553900..101572103)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A4 Neighboring gene transfer RNA serine (anticodon AGA) 17 Neighboring gene uncharacterized LOC120097182 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene uncharacterized LOC102556190 Neighboring gene uncharacterized LOC134485119 Neighboring gene transfer RNA proline (anticodon GGG) Neighboring gene fibroblast growth factor 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner. Moghei M, et al. Am J Physiol Cell Physiol, 2016 Sep 1. PMID 27488662, Free PMC Article
  2. Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation. Dhanani ZN, et al. Physiol Rep, 2019 Dec. PMID 31833233, Free PMC Article
  3. Identification of the mitochondrial branched chain aminotransferase as a branched chain alpha-keto acid transport protein. Hutson SM, et al. J Biol Chem, 1993 Feb 15. PMID 8428987
  4. Localization and expression of BCAT during pregnancy and lactation in the rat mammary gland. Tovar AR, et al. Am J Physiol Endocrinol Metab, 2001 Mar. PMID 11171603
  5. Ontogeny and subcellular localization of rat liver mitochondrial branched chain amino-acid aminotransferase. Torres N, et al. Eur J Biochem, 2001 Dec. PMID 11733007

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation.
    Title: Depletion of branched-chain aminotransferase 2 (BCAT2) enzyme impairs myoblast survival and myotube formation.
  2. The effect of KIC on insulin-stimulated glucose transport was abrogated in cells depleted of branched-chain aminotransferase 2 (BCAT2).
    Title: Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner.
  3. GDH1 facilitates regeneration of BCATm that binds to E1 decarboxylase of the branched-chain alpha-keto acid dehydrogenase enzyme complex, promotes metabolon formation, branched-chain amino acid oxidation, and cycling of nitrogen through glutamate.
    Title: Branched-chain amino acid metabolon: interaction of glutamate dehydrogenase with the mitochondrial branched-chain aminotransferase (BCATm).
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-isoleucine-2-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-leucine-2-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables L-valine-2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-valine-2-oxoglutarate transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables branched-chain-amino-acid transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables branched-chain-amino-acid transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables branched-chain-amino-acid transaminase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-leucine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-leucine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within branched-chain amino acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within branched-chain amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in branched-chain amino acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in isoleucine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isoleucine catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within isoleucine catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within isoleucine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lactation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of hormone levels IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hormone levels ISO
Inferred from Sequence Orthology
more info
  
involved_in valine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within valine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
branched-chain-amino-acid aminotransferase, mitochondrial
Names
BCAT(m)
branched chain amino acid transaminase 2, mitochondrial
branched chain aminotransferase 2, mitochondrial
heart branched chain aminotransferase precursor encoding mitochondrial protein
NP_071795.2
XP_006229211.1
XP_017445146.1
XP_038945432.1
XP_063128813.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022400.2 → NP_071795.2  branched-chain-amino-acid aminotransferase, mitochondrial precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O35854
    UniProtKB/TrEMBL
    A6JB55, G3V8U8
    Related
    ENSRNOP00000095006.1, ENSRNOT00000095787.2
    Conserved Domains (1) summary
    cd01557
    Location:88 → 383
    BCAT_beta_family; Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    105175157..105196474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089504.2 → XP_038945432.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    O35854
    Related
    ENSRNOP00000028474.4, ENSRNOT00000028474.7
    Conserved Domains (1) summary
    cd01557
    Location:103 → 398
    BCAT_beta_family; Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The ...

  2. XM_006229149.3 → XP_006229211.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006229211.1

    UniProtKB/Swiss-Prot
    O35854
    UniProtKB/TrEMBL
    A6JB56
    Conserved Domains (2) summary
    PRK13357
    Location:1 → 329
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:24 → 319
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

  3. XM_017589657.3 → XP_017445146.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    O35854
    UniProtKB/TrEMBL
    A6JB56
    Related
    ENSRNOP00000099982.1, ENSRNOT00000168131.1
    Conserved Domains (2) summary
    PRK13357
    Location:1 → 329
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:24 → 319
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

  4. XM_063272743.1 → XP_063128813.1  branched-chain-amino-acid aminotransferase, mitochondrial isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35854.1 GenPept UniProtKB/Swiss-Prot:O35854

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