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Pde4dip phosphodiesterase 4D interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 64183, updated on 10-Oct-2024

Summary

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Official Symbol
Pde4dipprovided by RGD
Official Full Name
phosphodiesterase 4D interacting proteinprovided by RGD
Primary source
RGD:708410
See related
EnsemblRapid:ENSRNOG00000018220 AllianceGenome:RGD:708410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables enzyme binding activity. Involved in cellular protein-containing complex assembly. Located in Golgi apparatus; centrosome; and myofibril. Orthologous to human PDE4DIP (phosphodiesterase 4D interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 3186.8), Heart (RPKM 1355.8) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Pde4dip in Genome Data Viewer
Location:
2q34
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187982002..188178937, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (185293236..185490100, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199867965..200066034, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 2 Neighboring gene uncharacterized LOC102550575 Neighboring gene transfer RNA glutamine (anticodon CUG) 4 Neighboring gene uncharacterized LOC134485662 Neighboring gene SEC22 homolog B, vesicle trafficking protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular Pathway of Microtubule Organization at the Golgi Apparatus. Wu J, et al. Dev Cell, 2016 Oct 10. PMID 27666745
  2. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. Verde I, et al. J Biol Chem, 2001 Apr 6. PMID 11134006
  3. Isolation of novel heart-specific genes using the BodyMap database. Soejima H, et al. Genomics, 2001 May 15. PMID 11374908
  4. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, et al. BMC Cell Biol, 2011 May 10. PMID 21569246, Free PMC Article
  5. EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions. Bouguenina H, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29162697, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MMGL isoform 4 is involved in the phosphorylation of Cardiac Myosin Binding Protein-C as well as cardiac troponin I.
    Title: Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cortical microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
located_in myofibril IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
myomegalin
Names
phosphodiesterase-binding protein clone 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389233.1 → NP_001376162.1  myomegalin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3C0
    Related
    ENSRNOP00000103442.1, ENSRNOT00000147765.1
    Conserved Domains (4) summary
    TIGR02168
    Location:434 → 1160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:128 → 592
    CCDC158; Coiled-coil domain-containing protein 158
    pfam06758
    Location:1677 → 1743
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:126 → 193
    Cnn_1N; Centrosomin N-terminal motif 1

  2. NM_001389234.1 → NP_001376163.1  myomegalin isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3C0, A6K3C1
    Related
    ENSRNOP00000099519.1, ENSRNOT00000167159.1
    Conserved Domains (4) summary
    TIGR02168
    Location:434 → 1160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:128 → 592
    CCDC158; Coiled-coil domain-containing protein 158
    pfam06758
    Location:1677 → 1743
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:126 → 193
    Cnn_1N; Centrosomin N-terminal motif 1

  3. NM_001389235.1 → NP_001376164.1  myomegalin isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3C0
    Conserved Domains (4) summary
    TIGR02168
    Location:434 → 1160
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:128 → 592
    CCDC158; Coiled-coil domain-containing protein 158
    pfam06758
    Location:1677 → 1743
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:126 → 193
    Cnn_1N; Centrosomin N-terminal motif 1

  4. NM_022382.2 → NP_071777.2  myomegalin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6K3C2, F1M7R5
    Related
    ENSRNOP00000024900.6, ENSRNOT00000024900.8
    Conserved Domains (4) summary
    TIGR02168
    Location:314 → 1040
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:8 → 461
    CCDC158; Coiled-coil domain-containing protein 158
    pfam06758
    Location:1557 → 1623
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:6 → 73
    Cnn_1N; Centrosomin N-terminal motif 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    187982002..188178937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282460.1 → XP_063138530.1  myomegalin isoform X21

    Related
    ENSRNOP00000078787.2, ENSRNOT00000100009.2

  2. XM_017591079.3 → XP_017446568.1  myomegalin isoform X14

    UniProtKB/TrEMBL
    A6K3C0

  3. XM_017591075.3 → XP_017446564.1  myomegalin isoform X6

    UniProtKB/TrEMBL
    A6K3C0

  4. XM_063282458.1 → XP_063138528.1  myomegalin isoform X19

  5. XM_017591078.3 → XP_017446567.1  myomegalin isoform X11

    UniProtKB/TrEMBL
    A6K3C0

  6. XM_063282453.1 → XP_063138523.1  myomegalin isoform X8

  7. XM_063282454.1 → XP_063138524.1  myomegalin isoform X9

  8. XM_017591072.3 → XP_017446561.1  myomegalin isoform X2

    UniProtKB/TrEMBL
    A6K3C0

  9. XM_063282457.1 → XP_063138527.1  myomegalin isoform X18

    Related
    ENSRNOP00000100013.1, ENSRNOT00000167057.1

  10. XM_039103040.2 → XP_038958968.1  myomegalin isoform X10

    UniProtKB/TrEMBL
    A6K3C0
    Conserved Domains (4) summary
    TIGR02168
    Location:508 → 1234
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:202 → 666
    CCDC158; Coiled-coil domain-containing protein 158
    pfam06758
    Location:1751 → 1817
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:200 → 267
    Cnn_1N; Centrosomin N-terminal motif 1

  11. XM_063282452.1 → XP_063138522.1  myomegalin isoform X7

  12. XM_063282451.1 → XP_063138521.1  myomegalin isoform X3

  13. XM_017591071.3 → XP_017446560.1  myomegalin isoform X1

    UniProtKB/TrEMBL
    A6K3C0

  14. XM_039103042.2 → XP_038958970.1  myomegalin isoform X13

    UniProtKB/TrEMBL
    A6K3C0
    Conserved Domains (4) summary
    TIGR02168
    Location:508 → 1234
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam15921
    Location:202 → 666
    CCDC158; Coiled-coil domain-containing protein 158
    pfam06758
    Location:1751 → 1817
    DUF1220; Repeat of unknown function (DUF1220)
    pfam07989
    Location:200 → 267
    Cnn_1N; Centrosomin N-terminal motif 1

  15. XM_017591080.3 → XP_017446569.1  myomegalin isoform X15

    UniProtKB/TrEMBL
    A6K3C0

  16. XM_017591074.3 → XP_017446563.1  myomegalin isoform X5

    UniProtKB/TrEMBL
    A6K3C0

  17. XM_063282462.1 → XP_063138532.1  myomegalin isoform X23

  18. XM_017591081.3 → XP_017446570.1  myomegalin isoform X16

    UniProtKB/TrEMBL
    A0A0G2JW66
    Related
    ENSRNOP00000069762.3, ENSRNOT00000088041.3

  19. XM_039103044.2 → XP_038958972.1  myomegalin isoform X24

    UniProtKB/TrEMBL
    F1M7R5
    Conserved Domains (3) summary
    TIGR00618
    Location:21 → 533
    sbcc; exonuclease SbcC
    TIGR02168
    Location:305 → 1031
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1548 → 1614
    DUF1220; Repeat of unknown function (DUF1220)

  20. XM_063282463.1 → XP_063138533.1  myomegalin isoform X25

  21. XM_039103045.2 → XP_038958973.1  myomegalin isoform X24

    UniProtKB/TrEMBL
    F1M7R5
    Conserved Domains (3) summary
    TIGR00618
    Location:21 → 533
    sbcc; exonuclease SbcC
    TIGR02168
    Location:305 → 1031
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1548 → 1614
    DUF1220; Repeat of unknown function (DUF1220)

  22. XM_039103043.2 → XP_038958971.1  myomegalin isoform X22

    UniProtKB/TrEMBL
    F1M7R5
    Conserved Domains (3) summary
    TIGR00618
    Location:41 → 553
    sbcc; exonuclease SbcC
    TIGR02168
    Location:325 → 1051
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1568 → 1634
    DUF1220; Repeat of unknown function (DUF1220)

  23. XM_063282471.1 → XP_063138541.1  myomegalin isoform X34

    UniProtKB/TrEMBL
    A0A8I6G2C1

  24. XM_063282459.1 → XP_063138529.1  myomegalin isoform X20

    UniProtKB/TrEMBL
    A0A8I6APT7

  25. XM_063282456.1 → XP_063138526.1  myomegalin isoform X17

  26. XM_063282470.1 → XP_063138540.1  myomegalin isoform X33

  27. XM_039103041.2 → XP_038958969.1  myomegalin isoform X12

    UniProtKB/TrEMBL
    A6K3C4
    Related
    ENSRNOP00000095141.2, ENSRNOT00000118806.2
    Conserved Domains (4) summary
    COG1196
    Location:2005 → 2236
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:476 → 1275
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06758
    Location:1719 → 1785
    DUF1220; Repeat of unknown function (DUF1220)
    pfam18615
    Location:1 → 375
    SMYLE_N; Short myomegalin-like EB1 binding proteins, N-terminal domain

  28. XM_017591073.3 → XP_017446562.1  myomegalin isoform X4

    UniProtKB/TrEMBL
    A6K3C4

  29. XM_063282465.1 → XP_063138535.1  myomegalin isoform X28

  30. XM_039103046.2 → XP_038958974.1  myomegalin isoform X26

    Conserved Domains (3) summary
    PRK02224
    Location:668 → 1137
    PRK02224; DNA double-strand break repair Rad50 ATPase
    TIGR02168
    Location:203 → 844
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam07989
    Location:200 → 267
    Cnn_1N; Centrosomin N-terminal motif 1

  31. XM_063282467.1 → XP_063138537.1  myomegalin isoform X31

  32. XM_063282466.1 → XP_063138536.1  myomegalin isoform X30

  33. XM_063282469.1 → XP_063138539.1  myomegalin isoform X32

  34. XM_063282464.1 → XP_063138534.1  myomegalin isoform X27

  35. XM_039103047.2 → XP_038958975.2  myomegalin isoform X29

RNA

  1. XR_001836491.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUJ3.1 GenPept UniProtKB/Swiss-Prot:Q9WUJ3

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