Ddah1 dimethylarginine dimethylaminohydrolase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddah1provided by RGD
Official Full Name: dimethylarginine dimethylaminohydrolase 1provided by RGD
Primary source: RGD:70968
See related: EnsemblRapid:ENSRNOG00000014613 AllianceGenome:RGD:70968
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables amino acid binding activity and dimethylargininase activity. Involved in arginine metabolic process; positive regulation of angiogenesis; and positive regulation of nitric oxide biosynthetic process. Human ortholog(s) of this gene implicated in cardiovascular system disease and hypertension. Orthologous to human DDAH1 (dimethylarginine dimethylaminohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 791.4), Liver (RPKM 98.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q44

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (237327812..237460624)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (234667499..234800322)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (251634368..251766009)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
Title: LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway.
Title: DDAH1/ADMA Regulates Adiponectin Resistance in Cerebral Ischemia via the ROS/FOXO1/APR1 Pathway.
DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.
Title: DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage.
DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion.
Title: DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion.
These data suggest that in C6 gliomas DDAH has no NO-independent effects on tumour growth and angiogenesis, and that the therapeutic potential of targeting DDAH in gliomas should only be considered in the context of NO regulation.
Title: Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo.
Fluid reabsorption in the proximal tubule is reduced by tubular ADMA or by blocking its metabolism by DDAH-1.
Title: Regulation of fluid reabsorption in rat or mouse proximal renal tubules by asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase 1.
IFX treatment was associated with an improvement in eNOS activity and increased L-arginine/ADMA ratio and DDAH1 expression.
Title: Post-Transcriptional Regulation of Hepatic DDAH1 with TNF Blockade Leads to Improved eNOS Function and Reduced Portal Pressure In Cirrhotic Rats.
Data show that interleukin-10 (IL-10) attenuates angiotensin II-induced dimethylarginine dimethylaminohydrolase (DDAH-1) inhibition in spontaneously hypertensive rats vascular smooth muscle cells.
Title: Dimethylarginine dimethylaminohydrolase-1 mediates inhibitory effect of interleukin-10 on angiotensin II-induced hypertensive effects in vascular smooth muscle cells of spontaneously hypertensive rats.
after cholestasis an increase in hepatic ADMA in RL and ML was detected as well as tissue MMP-2 and MMP-9 activation in RL, supporting the evidence of functional heterogeneity among the liver lobes also occurring in an obstructive cholestasis model.
Title: Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
The observed antihypertensive effects of NAC in young SHR might be due to restoration of DDAH activity to reduce ADMA, leading to attenuation of oxidative stress
Title: N-acetylcysteine prevents hypertension via regulation of the ADMA-DDAH pathway in young spontaneously hypertensive rats.

Submit: New GeneRIF Correction See all GeneRIFs (26)

General gene information

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Markers

D2Got166 (e-PCR)
- UniSTS:112518

RH140029 (e-PCR)
- UniSTS:222111

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amino acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid binding	IDA Inferred from Direct Assay more info	PubMed
enables dimethylargininase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dimethylargininase activity	IDA Inferred from Direct Assay more info	PubMed
enables dimethylargininase activity	ISO Inferred from Sequence Orthology more info
enables dimethylargininase activity	ISS Inferred from Sequence or Structural Similarity more info
enables dimethylargininase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arginine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in arginine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in citrulline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in citrulline metabolic process	ISO Inferred from Sequence Orthology more info
involved_in citrulline metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

Names: DDAH-1; DDAHI; NG,NG dimethylarginine dimethylaminohydrolase; dimethylargininase-1

NP_071633.1

EC 3.5.3.18

XP_017446557.1

EC 3.5.3.18

XP_063138520.1

EC 3.5.3.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022297.3 → NP_071633.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

See identical proteins and their annotated locations for NP_071633.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

O08557

UniProtKB/TrEMBL

A6HWC2

Related

ENSRNOP00000044971.3, ENSRNOT00000045016.6

Conserved Domains (1) summary

cl19186
Location:11 → 276

Amidinotransf; Amidinotransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

237327812..237460624

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591068.3 → XP_017446557.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X1

UniProtKB/TrEMBL

A6HWC3

Conserved Domains (1) summary

cl19186
Location:3 → 173

Amidinotransf; Amidinotransferase
XM_063282450.1 → XP_063138520.1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform X2